Accordin solution for injection 100mg/ml, 5ml x 10 ampoules — Made in Ukraine — Free Delivery

Product description

Accordin is indicated in the complex therapy of diseases:

• diseases of the heart and vascular system: stable exertional angina, chronic heart failure (NYHA I-II and functional class), cardiomyopathy, functional disorders of the heart and vascular system;
• acute and chronic ischemic disorders of cerebral circulation;
• decreased performance, physical and psycho-emotional overstrain;
• during the recovery period after cerebrovascular disorders, head trauma and encephalitis.

Compound

Active ingredient: 3- (2,2,2-trimethylhydrazinium) propionate dihydrate (meldonium);

1 ml of solution contains 3- (2,2,2-trimethylhydrazinium) propionate dihydrate - 100 mg.

Excipients: water for injection.

Contraindications

• hypersensitivity to meldonium and / or any of the excipients of the preparation;
• increased intracranial pressure (in violation of venous outflow, intracranial tumors);
• severe hepatic and / or renal impairment (there is insufficient data on the safety of use).

Mode of application

Intravenously. The use of the preparation does not provide for special preparation before administration.

Due to the possible stimulating effect, the preparation is recommended to be used in the first half of the day.

Adults. The dose is 500-1000 mg (5-10 ml) into a vein, it is administered at one time or divided into two doses. The duration of treatment is usually 10-14 days, after which the treatment is continued with an oral dosage form. The duration of the course of treatment is 4-6 weeks. The course of treatment can be repeated 2-3 times a year.

Elderly patients. Elderly patients with impaired liver and / or kidney function may reduce the dose of meldonium.

Patients with impaired renal function. Since the preparation is excreted by the body by the kidneys, patients with mild to moderate renal impairment should use a lower dose of meldonium.

Patients with impaired liver function. Patients with mild to moderate hepatic impairment should use a lower dose of meldonium.

Application features

Pregnant

The potential risk to humans is unknown, therefore meldonium is contraindicated during pregnancy.

Children

There are no data on the safety and efficacy of meldonium use in children under the age of 18, therefore, the use of meldonium in this category of patients is contraindicated.

Overdose

No cases of meldonium overdose have been reported. The preparation is low-toxic and does not cause threatening side effects.

With low blood pressure, headache, dizziness, tachycardia, weakness are possible. Treatment is symptomatic.

In case of severe overdose, it is necessary to monitor the functions of the liver and kidneys.

Hemodialysis is not essential in case of an overdose of meldonium due to the pronounced binding to blood proteins.

Side effects

• headache;
• allergic reactions;
• dispersion;
• dyslipidemia;
• increased levels of C-reactive protein.

Interaction

Meldonium can be used together with long-acting nitrates and other antianginal preparations (stable angina pectoris), cardiac glycosides and diuretic preparations (heart failure). It can also be combined with anticoagulants, antiplatelet agents, antiarrhythmics and other preparations that improve microcirculation.

Meldonium can enhance the effect of preparations containing glyceryl trinitrate, nifedipine, beta-blockers and other antihypertensive preparations and peripheral vasodilators.

Storage conditions

Store in its original packaging at a temperature not exceeding 25 ° C.

Keep out of the reach of children.

Shelf life is 2 years.

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