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    3. Acnestop 200mg/g 30 g — Made in Ukraine — Free Delivery

    Acnestop 200mg/g 30 g — Made in Ukraine — Free Delivery


    Brand: Kyivmedpreparat
    Product Code: Acnestop
    Availability: In Stock
    $35.19
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    Pharmacological properties

    Pharmacodynamics. Azelaic acid, the active ingredient of acnestop, is a straight-chain dicarboxylic acid found in nature, devoid of toxicity, teratogenicity and mutagenicity.
    It is believed that the therapeutic efficacy of Aknestop cream in the treatment of acne is determined by its antimicrobial effect and a direct effect on follicular hyperkeratosis.
    Clinically, there is a significant decrease in the density of colonization of Propionibacterium acnes and a significant decrease in the fraction of free fatty acids in the lipids of the skin surface.
    Azelaic acid in vitro and in vivo inhibits the proliferation of keratinocytes, normalizes the violation of the processes of terminal differentiation of the epidermis during the formation of acne. In a rabbit ear model, azelaic acid accelerates the comedolysis of tetradecane-induced comedones.
    At a concentration of 0.31–2.5%, a biocidal effect is manifested after prolonged contact for 30–120 minutes against gram-positive and gram-negative aerobic bacteria, anaerobic bacteria and fungi.
    In vitro studies have not demonstrated the presence of mutant forms resistant to azelaic acid in either Staphylococcus epidermidis or Propionibacterium acnes.
    Pharmacokinetics. After applying the cream, azelaic acid penetrates into all layers of the human skin. Penetration occurs at a faster rate through the affected skin than through intact skin. After a single application of 1 g of azelaic acid (5 g of cream) to the skin surface, 3.6% of the applied dose is subcutaneously adsorbed.
    Part of the azelaic acid absorbed through the skin is excreted unchanged in the urine. The other part is degraded by β-oxidation into short-chain dicarboxylic acids (C7, C5), which have also been found in urine.
    The study of systemic tolerance after repeated administration and topical application of azelaic acid did not reveal any signs that, even under extreme conditions, for example, when applied to a large area and / or with occlusion, the development of side effects can be expected.

    Indications

    Treatment of acne (acne vulgaris) characterized by comedones, papules, pustules and small nodules.

    Application

    Apply acnestop cream 2 times a day (morning and evening) to the affected skin and rub in gently. approximately 0.5 g = 2.5 cm of cream, which is sufficient for the entire surface of the face. before using acnestop cream, the skin should be thoroughly rinsed with water and dried. you can also use a mild cosmetic cleanser.
    It is important to apply the cream regularly throughout the course of treatment.
    The duration of the course of treatment may vary depending on the individual course of the disease and is determined by the degree of its severity.
    In patients with acne, significant improvement is usually noted after about 4 weeks. However, to achieve optimal results, it is recommended to use the preparation continuously for several months. There is clinical experience with the continuous use of a topical azelaic acid preparation for a period of up to 1 year.
    In case of excessive skin irritation (see SIDE EFFECTS), the amount of cream for application or the frequency of application of Aknestop cream should be reduced to 1 time per day until irritation disappears. If necessary, therapy can be interrupted for several days. After a short period of treatment without noticeable results, a second medical evaluation is necessary.

    Contraindications

    Hypersensitivity to the active substance or any of the excipients of the preparation.

    Side effects

    The frequency of adverse reactions was determined according to meddra: very often (≥1 / 10); often (from? 1/100 to 1/10); infrequently (from ≥1 / 1000 to 1/100); rarely (from? 1/10 000 to 1/1000), very rarely (1/10 000), the frequency is unknown (cannot be estimated from the available data).
    On the part of the skin and subcutaneous tissue: infrequently - seborrhea, acne, skin depigmentation; rarely - cheilitis (inflammation of the lips), rashes.
    Local disorders: very often - burning, itching and erythema; often - peeling, pain, dryness, discoloration of the skin and irritation at the site of application; infrequently - paresthesia, dermatitis, discomfort and swelling at the site of application; single - urticaria, ulcer at the site of application; rarely - vesicles, eczema, a feeling of warmth and an ulcer at the site of application. Local skin irritations usually disappear with treatment.
    From the immune system: rarely - hypersensitivity.
    Cases of exacerbation of asthma symptoms have been reported in patients using azelaic acid (frequency unknown).
    You should inform your doctor about the occurrence of any undesirable effects, including those not indicated in the instructions.
    Tolerance for topical application of the preparation  in children aged 12 years and older is similar to that in adults.

    Special instructions

    Designed exclusively for external use. it is not allowed to get the cream in the eyes, mouth or mucous membranes. in case of accidental contact with eyes, mouth and other mucous membranes, rinse immediately with plenty of water. if eye irritation persists, it is recommended to seek medical attention. hands should be washed after each application of the cream.
    The simultaneous use of cosmetic products, alcoholic or aggressive detergents, tinctures, astringents or abrasives or exfoliating agents should be limited during treatment as much as possible.
    Benzoic acid may cause mild irritation to the skin, eyes and mucous membranes. Propylene glycol can also irritate the skin.
    In rare cases, during post-registration observation, an exacerbation of asthma was reported in patients who used azelaic acid.
    Use during pregnancy and lactation. Pregnancy. There have been no adequate and well-controlled studies of azelaic acid topical preparations in pregnant women. Animal studies do not indicate direct or indirect harmful effects on pregnancy, embryo / fetal development, childbirth or postnatal development. In pregnant women, the preparation should be used with caution.
    Lactation. It is not known whether azelaic acid is excreted in breast milk in vivo. However, an in vitro experiment has demonstrated that the active substance can pass into breast milk. As expected, the distribution of azelaic acid in breast milk cannot lead to significant changes in relation to its baseline level, since it is not concentrated in breast milk and less than 4% of the topically applied azelaic acid is absorbed systemically (without increasing the endogenous exposure of the specified substance above the physiological level ). However, in women who are breastfeeding, the preparation should be used with caution.
    Avoid contact of the infant with the skin / breast treated with the preparation.
    Children. Used in adolescents from 12 years old. When using Aknestop cream in children aged 12 years and older, dose adjustment is not required. The safety and efficacy of Aknestop cream in children under 12 years of age have not been established.
    The ability to influence the reaction rate when driving and working with other mechanisms. Does not affect.

    Interactions

    Interaction studies have not been conducted.
    During controlled clinical trials, preparation interactions were not observed.
    Azelaic acid is chemically incompatible with alkalis, strong oxidants and reducing agents.
    Taking into account the composition of the cream, no undesirable interactions of the individual components are expected that could adversely affect the safety of the preparation.

    Overdose

    The results of acute toxicity studies do not indicate the existence of any risk of acute intoxication with a single overdose (applying the cream to a large surface of the skin under conditions favorable for adsorption) or with unintentional ingestion.

    Storage conditions

    In its original packaging at a temperature not exceeding 25 ° C. do not freeze!

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