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    3. Letero 2.5mg 30 tablets — Made in India — Free Delivery

    Letero 2.5mg 30 tablets — Made in India — Free Delivery


    Brand: Hetero Labs Limited
    Product Code: Letero
    Availability: In Stock
    $41.51
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    Product description

    Film-coated tablets Letero are indicated for:
    • Adjuvant therapy for hormone-positive invasive breast cancer in early stages in postmenopausal women.
    • Advanced adjuvant therapy for early invasive breast cancer in postmenopausal women who have received standard adjuvant tamoxifen therapy for 5 years.
    • First-line therapy for hormone-dependent advanced breast cancer in postmenopausal women.
    • Treatment of common forms of breast cancer in postmenopausal women (natural or induced) after relapse or progression of the disease, who received previous antiestrogen therapy.
    • Neoadjuvant therapy in postmenopausal women with hormone-positive, HER-2-negative breast cancer who are unsuitable for chemotherapy and are not indicated for urgent surgery.

    Compound

    Active substance: letrozole;
    1 coated tablet contains letrozole 2.5 mg;
    Excipients: lactose monohydrate, silicon dioxide colloidal sodium croscarmellose; magnesium stearate povidone, shell: Opadry yellow 03B82401 (hypromellose, titanium dioxide (E 171), iron oxide yellow (E172), polyethylene glycol, talc).

    Contraindications

    Hypersensitivity to the active substance or to any other component of the preparation.
    Endocrine status characteristic of the premenopausal period.
    Pregnancy, lactation period.
    Women of reproductive age.

    Mode of application

    The preparation should be taken orally with or without food, since food does not affect absorption.
    The missed dose should be taken as soon as the patient remembers it. However, if the patient remembers this shortly before taking the next dose (2-3 hours), the missed dose should be skipped and the next dose should be taken according to the schedule. You should not take a double dose, because when taking a daily dose higher than the recommended 2.5 mg, a systemic exposure higher than the proportional one was observed.

    Application features

    Pregnant
    Not applicable.
    Children
    Not applicable.
    Drivers
    The effect of letrozole on the ability to drive vehicles and operate machinery is negligible. Since during the treatment with the preparation in patients, general weakness and dizziness were observed, in some cases - drowsiness, patients should be warned that when these symptoms occur, they should refuse to drive vehicles or work with mechanisms.

    Overdose

    Reported isolated cases of preparation overdose.
    The specific treatment for overdose is unknown; treatment should be symptomatic and supportive.

    Side effects

    Fatigue (including asthenia, malaise), peripheral edema, chest pain, fever, dry mucous membranes, thirst, generalized edema.

    Interaction

    Inhibitors of the activity of CYP3A4 and CYP2A6 can reduce the metabolism of letrozole and thus increase the concentration of letrozole in the blood plasma. Concomitant use of preparations that strongly inhibit these enzymes (powerful inhibitors of CYP3A4 include, but are not limited to: ketoconazole, itraconazole, voriconazole, ritonavir, clarithromycin, and telithromycin; CYP2A6 (eg, methoxalen)) may increase letrozole exposure. Therefore, patients who are shown potent inhibitors of CYP3A4 and CYP2A6 are advised to exercise caution when using them.

    Storage conditions

    Store in the original manufacturer's packaging at a temperature not exceeding 25 ° C.
    Shelf life is 3 years.

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