Biseptol tablets are used to treat infections caused by pathogenic microorganisms sensitive to the preparation, in cases where the benefit from such treatment outweighs the possible risk (it is necessary to decide whether only one antibacterial agent can be used):
Active ingredients: sulfamethoxazole, trimethoprim (co-trimoxazole);
1 tablet 100 mg / 20 mg contains 100 mg sulfamethoxazole, 20 mg trimethoprim;
1 tablet 400 mg / 80 mg contains sulfamethoxazole 400 mg trimethoprim 80 mg;
Excipients: potato starch, talc, magnesium stearate, polyvinyl alcohol.
Adults and children over 12 years old. The usual starting dose is two tablets 2 times a day (morning and evening). The tablets should be taken after meals with plenty of liquid. In severe infections, higher daily doses can be prescribed - up to 3 tablets 2 times a day. For maintenance therapy lasting more than 14 days, it is recommended to take one tablet 2 times a day.
Children 6-12 years old. The recommended daily dose for children is 6 mg of trimethoprim and 30 mg of sulfamethoxazole per kg of body weight. This dose should be divided into two doses.
The recommended daily dose for children aged 6 to 12 years is one tablet 2 times a day.
Duration of treatment: for acute infections, with the exception of gonorrhea, treatment should be continued for at least 5 days or 2 more days after the symptoms of the disease disappear. A three-day course of treatment may be sufficient for women with uncomplicated acute cystitis. However, children with this disease are recommended to use the preparation for 5-7 days.
Pregnant
This preparation should not be used during pregnancy and lactation.
Children
The preparation is used to treat children over 6 years old.
Drivers
The preparation does not cause a decrease in psychophysical activity and the ability to drive vehicles and maintain mechanisms. If during treatment, side effects from the nervous system (dizziness, headache, convulsions, nervousness, feeling of fatigue) develop, which can cause a decrease in the speed of psychomotor reactions, you should avoid driving and working with complex mechanisms.
It is not known what dose of the preparation can be life-threatening. In case of an overdose of sulfonamides, there is a lack of appetite, colicky pain, nausea, vomiting, diarrhea, dizziness, headache, drowsiness, loss of consciousness. Fever, hematuria and crystalluria may appear, with chronic overdose, bone marrow suppression and hepatitis may develop. In acute overdose of trimethoprim, nausea, vomiting, dizziness, headache, mental depression, confusion, and bone marrow suppression may occur.
If symptoms of an overdose appear, it is necessary to stop using the preparation, induce vomiting, take a large amount of liquid, if the urine output is insufficient, and the kidney function is normal. Acidification of urine will speed up the elimination of trimethoprim, but increase the risk of sulfonamide crystallization in the kidneys. The blood picture, serum electrolytes and other biochemical parameters of the patient should be monitored. If bone marrow damage or symptoms of hepatitis develop, the usual treatment should be applied. Hemodialysis is ineffective. Peritoneal dialysis is ineffective.
In chronic poisoning, inhibition of the function of the spinal cord is observed, manifesting thrombocytopenia, leukopenia, or megaloblastic anemia. In this case, leucovorin should be used (5-15 mg per day).
The most common adverse reactions during preparation treatment are from the digestive tract (nausea, vomiting, lack of appetite) and allergic skin reactions (rash, urticaria).
Zidovudine: In some cases, the simultaneous use of co-trimoxazole and zidovudine increases the risk of hematological disorders caused by Biseptol. If the simultaneous use of co-trimoxazole and zidovudine is necessary, blood counts should be monitored.
Folinic acid has been shown that the additional use of folic acid affects the antimicrobial efficacy of trimethoprim-sulfamethoxazole. This has been observed in the prevention and treatment of pneumocystis jiroveci pneumonia.
Store at a temperature not exceeding 25 ° C.
Keep out of the reach of children.
The shelf life is 5 years.
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