Combined preparation for external use with antimicrobial, anti-inflammatory and local anesthetic properties. the pharmacological action of Candibiotic is due to the properties of chloramphenicol, clotrimazole, beclomethasone dipropionate and lidocaine, which are included in its composition. chloramphenicol is an amphenicol derivative. possesses a wide spectrum of antimicrobial action. the effect of chloramphenicol on microorganisms is associated with its ability to influence protein synthesis in bacteria. as a rule, acts bacteriostatically against a wide range of gram-positive and gram-negative microorganisms; also active against anaerobic flora.
According to its chemical structure, clotrimazole is an imidazole derivative. Dermatophytes, yeast fungi (genus Candida, Torulopsis glabarata, Rhodotorula), mold fungi, as well as pathogens of varicoloured lichen and erythrasma are sensitive to clotrimazole. In addition, clotrimazole has an antimicrobial effect against gram-positive (staphylococci, streptococci) and gram-negative bacteria (Bacteroides, Gardnerella vaginalis), as well as against Trichomonas vaginalis, Malassezia furfur, Corinebacterium minussimum. The effect of clotrimazole is associated with the ability to disrupt the synthesis of ergosterol, which is part of the cell membrane of fungi. As a result, the structure and properties of membranes are disrupted and cell lysis occurs.
Beclomethasone dipropionate - synthetic GCS - has anti-inflammatory, anti-allergic, anti-exudative and antipruritic effects.
Lidocaine is a local anesthetic that reduces the perception and conduction of impulses along sensitive nerve fibers at the site of action, having a reversible effect.
Allergic and inflammatory diseases of the ear, otorrhea, infections of the outer and middle ear caused by microorganisms sensitive to the action of the preparation, surgical interventions on the mastoid process.
Apply topically. for adults and children over the age of 12, 3-4 drops of the preparation are instilled into the external auditory canal 3-4 times a day. the duration of the course of treatment is set individually, taking into account the nature of the disease.
Hypersensitivity to the components of the preparation. like other topical agents containing GCS, Candibiotic is not prescribed for chickenpox, herpes simplex.
Candibiotic is generally well tolerated. rarely, with hypersensitivity to the components of the preparation, local allergic reactions may occur - a burning sensation and tingling sensation at the site of application of the preparation. if side effects occur, the preparation is canceled.
For external use only. despite the fact that there is no data on the negative effect of the preparation on the fetus and infant when used during pregnancy and lactation, the safety of its use in these categories of patients has not been finally established.
Not identified.
Acute overdose with topical application of Candibiotic is unlikely.
In a dry, dark place at temperatures up to 25 ° C.
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