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    3. Coronal 10, 10mg 60 tablets — Made in Slovakia — Free Delivery

    Coronal 10, 10mg 60 tablets — Made in Slovakia — Free Delivery


    Brand: Zentiva
    Product Code: Coronal 10
    Availability: In Stock
    $20.72
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    Indications.

    Arterial hypertension;
    ischemic heart disease (angina pectoris)
    chronic heart failure with systolic dysfunction of the left ventricle in combination with ACE inhibitors, diuretics, if necessary - with cardiac glycosides.

    Contraindications.

    • Acute heart failure or decompensated heart failure requiring inotropic therapy
    • cardiogenic shock
    • block II and III degree (with the exception of such in patients with an artificial pacemaker)
    • sick sinus syndrome;
    • sinoatrial blockade
    • symptomatic bradycardia
    • symptomatic arterial hypotension
    • severe form of bronchial asthma
    • late stages of peripheral circulatory disorders or Raynaud's disease
    • pheochromocytoma, not treated;
    • metabolic acidosis,
    • hypersensitivity to bisoprolol or other components of the preparation.

    Compound

    active ingredient: bisoprolol;
    1 tablet contains 10 mg of bisoprolol fumarate;
    Excipients:
    Coronal® 10: microcrystalline cellulose, corn starch, sodium lauryl sulfate, colloidal silicon dioxide, magnesium stearate, hypromellose, macrogol 400, titanium dioxide (E 171), iron oxide red (E 172).

    Method of application and dose.

    The preparation should be taken without chewing, in the morning on an empty stomach, during or after breakfast, with a small amount of liquid.
    Arterial hypertension; ischemic heart disease (angina pectoris).
    Treatment should be initiated gradually at low doses followed by dose increases. The recommended dose is 5 mg (1 tablet of 5 mg) per day. With a mild degree of hypertension (diastolic pressure up to 105 mm Hg), a dose of 2.5 mg (½ tablet of the preparation, 5 mg each) is suitable.
    If necessary, the daily dose can be increased to 10 mg (1 tablet of 10 mg) per day. A further increase in dose is justified only in exceptional cases. The maximum recommended dose is 20 mg per day.
    Dose adjustment is carried out by the doctor individually, depending on the pulse rate and therapeutic benefit.
    Chronic heart failure with systolic dysfunction of the left ventricle in combination with ACE inhibitors, diuretics, if necessary - with cardiac glycosides.
    Standard therapy for chronic heart failure: ACE inhibitors (or angiotensin receptor blockers in case of intolerance to ACE inhibitors), blockers
    ß-adrenergic receptors, diuretics and, if necessary, cardiac glycosides.
    The preparation is prescribed for the treatment of patients with chronic heart failure without signs of exacerbation.
    Therapy should be carried out by a doctor with experience in the treatment of chronic heart failure.
    Treatment of stable chronic heart failure with the preparation begins in accordance with the titration scheme presented below, which can be adjusted depending on the individual reactions of the body.
    1.25 mg * bisoprolol fumarate once a day for 1 week, if well tolerated, increase to
    2.5 mg* bisoprolol fumarate once daily for the next 1 week, if well tolerated, increase to
    3.75 mg * bisoprolol fumarate once a day for the next 1 week, if well tolerated, increase to
    5 mg bisoprolol fumarate once a day for the next 4 weeks, if well tolerated, increase to
    7.5 mg bisoprolol fumarate once a day for the next 4 weeks, if well tolerated, increase to
    10 mg of bisoprolol fumarate 1 time per day as maintenance therapy.
    * At the beginning of therapy for chronic heart failure, it is recommended to use dosages of 2.5 mg. To obtain a dose of 2.5 mg, a 5 mg tablet of the preparation can be divided in half.
    The maximum recommended dose of bisoprolol fumarate is 10 mg once daily.
    During the titration phase, monitoring of vital signs such as blood pressure, heart rate, and symptoms of progression of heart failure is necessary. Symptoms can develop from the first day after the start of treatment.
    Treatment modification.
    If the maximum recommended dose is not well tolerated, a gradual dose reduction is possible. If during or after the titration phase there is a gradual worsening of heart failure, arterial hypotension or bradycardia develops, dose adjustment of the preparation is recommended, which may require a temporary reduction in the dose of bisoprolol or, possibly, suspension of treatment. After stabilization of the patient's condition, the possibility of re-initiation of treatment with bisoprolol should always be considered.
    Do not stop treatment with the preparation suddenly, especially in patients with coronary heart disease, as this may lead to a deterioration in the patient's condition. If necessary, treatment is recommended to be completed slowly, gradually reducing the dose (for example, reducing the dose by half weekly).

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