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    3. Decamevit 20 tablets — Made in Ukraine — Free Delivery

    Decamevit 20 tablets — Made in Ukraine — Free Delivery


    Brand: Kyiv Vitamin Plant
    Product Code: Decamevit
    Availability: In Stock
    $20.72
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    Pharmacological properties

    Pharmacodynamics. Multivitamin preparation, the properties of which are due to the vitamins that make up its composition and take an active part in almost all biochemical reactions of the body. rationally selected composition contributes to the manifestation of a more pronounced and versatile biological effect of the preparation.
    Vitamin A (retinol acetate) is essential for the development of epithelial cells and the synthesis of visual pigment.
    Vitamin E (α-tocopherol acetate) - a fat-soluble vitamin with a pronounced antioxidant and radioprotective effect, takes part in the biosynthesis of heme and proteins, cell proliferation and other most important processes of cellular metabolism, improves tissue oxygen consumption, and also has an angioprotective effect, affecting vascular tone and permeability, stimulating the formation of new capillaries.
    Vitamin B1 (thiamine hydrochloride) normalizes the functional activity of the nervous, cardiovascular and digestive systems.
    Vitamin B2 (riboflavin) plays an important role in protein, fat and carbohydrate metabolism, takes part in maintaining normal visual acuity, and normalizes skin functions.
    Vitamin B6 (pyridoxine hydrochloride) is necessary for the regeneration of the skin and liver cells, restoration of the nervous system, and improves fat metabolism in atherosclerosis.
    Vitamin C (ascorbic acid) plays an important role in the regulation of redox processes, carbohydrate metabolism, blood clotting, tissue regeneration, normal capillary permeability, the formation of steroid hormones and connective tissue components, and helps to increase the body's resistance to infectious diseases.
    Vitamin B9 (folic acid), in addition to the antianemic effect during pregnancy, protects the fetus from the influence of teratogenic factors, takes part in the exchange and synthesis of amino and nucleic acids.
    Vitamin PP (nicotinamide) is a specific anticellargic agent that improves carbohydrate metabolism.
    Vitamin P (rutin) - P-vitamin-like water-soluble substance, flavonoid. Rutin interacts with ascorbic acid, takes part in the regulation of connective tissue collagen formation, prevents depolymerization of hyaluronic acid by hyaluronidase, and activates tissue respiration.
    The irreplaceable amino acid methionine plays a role in the synthesis of a number of biologically important compounds, activates the effects of hormones, vitamins and enzymes, and neutralizes toxic products.
    Vitamin B12 (cyanocobalamin) affects the processes of normal maturation of all cells in the body, especially blood and liver cells, and has a positive effect on the functioning of the nervous system and liver.
    Pharmacokinetics. Fat-soluble vitamins that are part of the preparation (vitamin A, vitamin E) are able to be deposited in tissues. Water-soluble vitamins (vitamins B1, B2, B6, B12, C, PP) are converted into coenzymes and, combining with the apoenzyme, are part of complex enzymes. Since the lifespan of enzymes is limited, coenzymes are broken down and excreted from the body in the form of various metabolites. Fat-soluble vitamins are also catabolized and excreted from the body, although at a slower rate than water-soluble vitamins.

    Indications

    As a remedy for vitamin deficiency and hypovitaminosis, increased body demand for vitamins under the following conditions:
    with physical and mental exhaustion;
    in old age to optimize metabolism;
    for convalescence in the postoperative period, after serious illnesses, including intoxication of various origins;
    with prolonged antibiotic therapy.

    Application

    For therapeutic purposes, adults inside after meals, 1 tablet 1-2 times a day. the course of treatment is usually 20 days. depending on the indications, repeated courses are possible with intervals between them in 2-3 months.

    Contraindications

    Hypersensitivity to any component of the preparation, severe renal dysfunction, gout, hyperuricemia, erythremia, erythrocytosis, thromboembolism, fructose intolerance, hypervitaminosis a and e, thyrotoxicosis, chronic glomerulonephritis, chronic heart failure, gastric sarcoidosis and duodenal ulcer intestines, metabolic disorders of iron or copper, thrombosis, tendency to thrombosis, thrombophlebitis, urolithiasis, incurable cobalamin deficiency, pernicious anemia, malignant neoplasms.

    Side effects

    The preparation is usually well tolerated, but sometimes side reactions can occur, mainly when used in high doses.
    From the side of the immune system: in persons with hypersensitivity, allergic reactions are possible, including anaphylactic shock, angioedema, hyperthermia; rarely - bronchospasm in persons with hypersensitivity to vitamins A, C, group B.
    From the endocrine system: damage to the insular apparatus of the pancreas (hyperglycemia, glucosuria) and impaired glycogen synthesis before the onset of diabetes mellitus.
    Skin and subcutaneous tissue disorders: rashes, urticaria, itching, skin redness, eczema.
    From the side of the cardiovascular system: arterial hypertension / hypotension, myocardial dystrophy.
    From the nervous system: headache, dizziness, irritability, fatigue, sleep disturbance, drowsiness, feeling of heat.
    From the digestive tract: dyspeptic disorders, heartburn, bitterness in the mouth, nausea, vomiting, diarrhea, anorexia; rarely - an increase in gastric acid secretion is possible.
    From the side of the kidneys and urinary system: damage to the glomerular apparatus of the kidneys, crystalluria, the formation of urate, cystine and / or oxalate calculi in the kidneys and urinary tract, renal failure.
    From the side of metabolism: metabolic disorders of zinc, copper.
    On the part of the blood and lymphatic system: thrombocytosis, hyperprothrombinemia, thrombosis, erythrocytopenia, neutrophilic leukocytosis; in patients with deficiency of glucose-6-phosphate dehydrogenase of blood cells, it can cause hemolysis of erythrocytes, hemolytic anemia.
    Others: urine may turn yellow, sweating, blurred vision.
    With prolonged use of the preparation in high doses, the following are possible: irritation of the gastrointestinal mucosa, paresthesia, hyperuricemia, transient increase in the activity of AST, LDH, ALP, decreased glucose tolerance, hyperglycemia, impaired renal function, dryness and cracks on the palms and feet, hair loss, seborrheic rashes, tachycardia, arrhythmia.

    Special instructions

    Women who have used high doses of retinol (over 10,000 IU) can plan pregnancy no earlier than 6–12 months. this is due to the fact that during this time there is a risk of abnormal development of the fetus under the influence of the high content of vitamin a in the body.
    It is possible that urine stains yellow, which is a completely harmless factor and is explained by the presence of riboflavin in the preparation.
    Use with caution in patients with kidney disease, with severe liver damage, history of peptic ulcers of the stomach and duodenum, acute nephritis, with decompensation of cardiac activity, cholelithiasis, chronic pancreatitis, ischemic heart disease, diabetes mellitus.
    The preparation should be prescribed with caution to patients with neoplasms (except for cases accompanied by megaloblastic anemia).
    The preparation  is prescribed with caution to patients with anemia of unknown etiology, since folic acid can interfere with the diagnosis of malignant anemia by reducing the severity of hematological manifestations of the disease, while allowing neurological complications to progress.
    When used in high doses or long-term use of the preparation, it is necessary to control the blood pressure level. The simultaneous use of the preparation with an alkaline drink reduces the absorption of ascorbic acid, so you should not drink it with alkaline mineral water. Also, the absorption of ascorbic acid can be impaired in case of intestinal dyskinesia, enteritis and achilia. Use with caution for the treatment of patients with glucose-6-phosphate dehydrogenase deficiency. Ascorbic acid may interfere with laboratory test results. For example, when determining blood glucose, bilirubin, transaminase activity, LDH.
    You should not prescribe high doses of the preparation to patients with increased blood clotting.
    Since ascorbic acid increases iron absorption, high doses can be dangerous for patients with hemochromatosis, thalassemia, polycythemia, leukemia, and sideroblastic anemia. Patients with a high iron content in the body should use the preparation in minimal doses.
    Since ascorbic acid has a mild stimulating effect, it is not recommended to use the preparation at the end of the day.
    Use during pregnancy and lactation. During pregnancy and lactation, the preparation is taken only on the recommendation of a doctor. The dose of vitamin A should not exceed 5000 IU in pregnant women and those planning a pregnancy.
    Retinol should not be taken in high doses (over 10,000 IU) during breastfeeding due to the threat of hypervitaminosis A in infants.
    Children. Due to the lack of data on safety and efficacy, the preparation is not used in children.
    The ability to influence the reaction rate when driving or working with other mechanisms. Drivers and operators of complex machinery should take into account the likelihood of side effects such as dizziness, drowsiness.

    Interactions

    The preparation is not recommended to be prescribed together with other multivitamins, since an overdose of the latter in the body is possible.
    High doses of the preparation reduce the effectiveness of tricyclic antidepressants, antipsychotics - phenothiazine derivatives, tubular reabsorption of amphetamine, and interfere with the excretion of mexiletine by the kidneys.
    Due to the possibility of developing hypervitaminosis A, concomitant use of the preparation with other preparations containing vitamin A or with oral retinoids is not recommended.
    Retinol reduces the anti-inflammatory effect of glucocorticoids. Cannot be used simultaneously with nitrites and cholestyramine, since they interfere with the absorption of retinol.
    Medicines containing iron inhibit the effect of vitamin E. Vitamin E should not be used together with preparations of iron, silver, agents that have an alkaline medium (such as sodium bicarbonate, trisamine), indirect anticoagulants (such as dicoumarin, neodycoumarin). Alpha-tocopherol acetate enhances the action of steroidal and non-steroidal anti-inflammatory preparations (such as sodium diclofenac, ibuprofen, prednisolone).
    Thiamine hydrochloride, influencing the polarization processes in the area of ​​neuromuscular synapses, can weaken the curariform effect of muscle relaxants.
    Pyridoxine hydrochloride weakens the action of levodopa, prevents the occurrence or reduces the toxic manifestations of isoniazid and other anti-tuberculosis preparations.
    When using short-acting sulfonamides with ascorbic acid, the risk of crystalluria increases. With simultaneous use, it enhances the effect of penicillin, increases the absorption of iron, reduces the effectiveness of heparin and indirect anticoagulants, enhances the absorption of aluminum (taken into account while treating with antacids containing aluminum). The absorption of ascorbic acid decreases with simultaneous use with oral contraceptives, the use of fruit or vegetable juices, and alkaline drinks. Ascorbic acid can be used only 2 hours after deferoxamine injection. Long-term use of high doses of ascorbic acid reduces the effectiveness of treatment with disulfiram. Ascorbic acid increases the total clearance of ethyl alcohol. Medicines of the quinolone series, calcium chloride, salicylates, tetracyclines, corticosteroids, with prolonged use, reduce the reserves of ascorbic acid in the body. Ascorbic acid increases urinary excretion of oxalates and increases the risk of crystalluria when treated with salicylates.
    Riboflavin is incompatible with streptomycin and reduces the effectiveness of antibacterial preparations (oxytetracycline, doxycycline, erythromycin, tetracycline and lincomycin). The tricyclic antidepressants, imipramine and amitriptyline, inhibit the metabolism of riboflavin, especially in the tissues of the heart.
    Folic acid reduces plasma concentrations of phenytoin with other antiepileptic preparations, in particular phenobarbital, which causes a mutual decrease in clinical efficacy.
    Ethanol, cycloserine, glutethimide, and methotrexate can interfere with folate metabolism. The absorption of folic acid decreases with simultaneous use with analgesics, anticonvulsants, antacids, sulfonamides, antibiotics, cytostatics. A decrease or change in absorption can occur with the simultaneous use of cholestyramine and folic acid. Therefore, the preparation should be taken 1 hour before or 4–6 hours after taking cholestyramine. Cannot be used together with mineral acids, reducing agents, since folic acid is inactivated.

    Overdose

    Symptoms in case of preparation overdose, dyspeptic phenomena (nausea, vomiting, diarrhea, epigastric pain), allergic reactions (itching, skin rash), changes in the skin and hair, impaired liver function, headache, drowsiness, lethargy, facial flushing, irritability, increased excitability of the central nervous system, which can cause convulsions.
    Treatment. Discontinuation of the preparation. Therapy is symptomatic.
    With long-term use in high doses, it is possible to suppress the function of the insular apparatus of the pancreas, monitoring the state of the latter is required. Overdose can lead to changes in renal excretion of ascorbic and uric acids during urine acetylation with the risk of precipitation of oxalate calculi.

    Storage conditions

    In its original packaging at a temperature not exceeding 25 ° C.

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