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    3. Doprokin 10mg 2p x 20 tablets — Made in Turkey — Free Delivery

    Doprokin 10mg 2p x 20 tablets — Made in Turkey — Free Delivery


    Brand: World Medicine İlaç Sanayi ve Ticaret A.Ş.
    Product Code: Doprokin
    Availability: In Stock
    $31.12
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    Product description

    Doprokin tablets are used to relieve symptoms of nausea and vomiting.

    Compound

    Active substance: domperidone;
    1 tablet contains domperidone (in the form of domperidone maleate) 10 mg;
    Excipients: lactose monohydrate, corn starch, corn starch; povidone (K90) sodium lauryl sulfate; cellulose microcrystalline vegetable oil hydrogenated magnesium stearate.

    Contraindications

    Doprokin is contraindicated:
    • patients with established hypersensitivity to the preparation or to excipients;
    • patients with prolactin-secretory pituitary tumor (prolactinoma);
    • patients with severe or moderate impairment of liver and / or kidney function;
    • patients with a known lengthening of cardiac conduction intervals, in particular QTc, patients with significant electrolyte imbalance or with underlying heart diseases such as congestive heart failure;
    • patients with liver failure;
    • if stimulation of the motor function of the stomach can be dangerous, for example, with gastrointestinal bleeding, mechanical obstruction or perforation;
    • concomitant use of ketoconazole, erythromycin or other potent CYP3A4 inhibitors is contraindicated;
    • concomitant use of preparations that prolong the QT interval, such as fluconazole, erythromycin, itraconazole, oral ketoconazole, posaconazole, ritonavir, saquinavir, telaprevir, voriconazole, clarithromycin, amiodarone, telithromycin, is contraindicated.

    Mode of application

    Adults and children over 12 years old and weighing at least 35 kg: one tablet (10 mg) 3 times a day. The maximum daily dose is 3 tablets (30 mg per day).
    It is recommended to take the preparation Doprokin before meals. The absorption of the preparation is somewhat delayed if taken after meals. The duration of treatment should not exceed one week.

    Application features

    Pregnant
    The preparation should be prescribed during pregnancy only when, in the opinion of the doctor, the expected positive effect for the mother outweighs the potential risk for the fetus.
    Children
    The preparation is used to treat children over 12 years of age and weighing at least 35 kg. Domperidone should be given to children at the most effective dose for a short period.
    Drivers
    Dizziness and drowsiness were observed after using domperidone. Therefore, patients should be advised to refrain from driving, operating machinery or other activities that require concentration and coordination until it has been established how the preparation affects them.

    Overdose

    Symptoms
    Overdose symptoms may include agitation, impaired consciousness, seizures, disorientation, drowsiness, and extrapyramidal reactions.
    Treatment
    There is no specific antidote to domperidone, but in case of a significant overdose, gastric lavage is recommended within one hour after taking the preparation and the use of activated charcoal, as well as careful monitoring of the patient and supportive therapy. Anticholinergics, preparations for the treatment of Parkinson's disease, can be effective in controlling extrapyramidal reactions.

    Side effects

    Estimation of the incidence of adverse reactions: very often (≥ 1/10); often (≥ 1/100, <1/10); infrequently (≥ 1/1000, <1/100); rarely (≥ 1/10000, <1/1000); very rare (<1/10000), including isolated data; the frequency is unknown (cannot be estimated from the available data).
    Subject to the recommendations for dosage and duration of treatment, domperidone is usually well tolerated and adverse events are rare.
    From the immune system: very rarely - allergic reactions, including anaphylaxis, anaphylactic shock, hypersensitivity.
    From the endocrine system: rarely - an increase in the level of prolactin.
    Mental disorders: very rarely - nervousness, irritability, agitation, depression, anxiety, decreased or lack of libido.
    From the side of the nervous system: very rarely - insomnia, dizziness, thirst, convulsions, lethargy, headache, drowsiness, akathisia, extrapyramidal disorders.
    From the side of the cardiovascular system: very rarely - edema, palpitations, disturbances in the frequency and rhythm of heart contractions, prolongation of the QT interval (frequency unknown), serious ventricular arrhythmias, ventricular arrhythmias of the torsade de pointes type, sudden cardiac death.
    From the gastrointestinal tract: rarely - gastrointestinal disorders, including abdominal pain, regurgitation, changes in appetite, nausea, heartburn, constipation; very rarely - dry mouth, short-term intestinal cramps, diarrhea.
    On the part of the skin and subcutaneous tissues: very rarely - itching, rash; frequency unknown - urticaria, angioedema.
    From the reproductive system and mammary glands: rarely - galactorrhea, breast enlargement / gynecomastia, breast sensitivity, discharge from the mammary glands, amenorrhea, edema of the mammary glands, pain in the mammary glands, impaired lactation, irregular menstrual cycle.
    From the musculoskeletal system and connective tissue: rarely - pain in the legs.
    From the urinary system: very rarely - urinary retention, dysuria, frequent urination.
    From the side of the organs of vision: the frequency is unknown - oculogyric crisis.

    Storage conditions

    Store in its original packaging at a temperature not exceeding 25 ° C, out of the reach of children.
    Shelf life is 3 years.

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