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    3. Duodart 0.5mg/0.4mg, 90 capsules — Made in Germany — Free Delivery

    Duodart 0.5mg/0.4mg, 90 capsules — Made in Germany — Free Delivery


    Brand: GlaxoSmithKline
    Product Code: Duodart
    Availability: In Stock
    $105.40
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    Product description 

    Duodart hard capsules are indicated for:
    • Treatment of moderate to severe symptoms of benign prostatic hyperplasia.
    • Reducing the risk of acute urinary retention and the need for surgery in patients with moderate to severe symptoms of benign prostatic hyperplasia.

    Compound

    Active ingredients: dutasteride, tamsulosin hydrochloride;
    1 capsule contains dutasteride 0.5 mg and tamsulosin hydrochloride 0.4 mg;
    Excipients: monodiglycerides of caprylic acid, butylhydroxytoluene (E 321), gelatin, glycerin, titanium dioxide (E 171), yellow iron oxide (E172), medium chain triglycerides and lecithin; microcrystalline cellulose, methacrylate copolymer dispersion, talc, triethyl citrate;
    Hard capsule shell: carrageenan (E 407), potassium chloride, titanium dioxide (E 171), FD&C Yellow 6 (E 110), hypromellose, carnauba wax, corn starch, iron oxide red (E172), SW-9008 Black Ink (shellac, propylene glycol, black iron oxide (E172), potassium hydroxide).

    Contraindications

    Duodart is not used to treat women and children.
    Duodart is contraindicated in patients with hypersensitivity to dutasteride, other 5a-reductase inhibitors, tamsulosin (including tamsulosin-induced angioedema), other components of the preparation, or to soy and peanuts.
    Duodart is contraindicated in patients with a history of orthostatic arterial hypotension.
    Duodart is contraindicated in patients with severe hepatic impairment.

    Mode of application

    The recommended dose of Duodart is 1 capsule (0.5 mg / 0.4 mg) per day. The preparation is taken orally 30 minutes after a meal at the same time. Swallow the capsule whole, do not open or chew, as contact with the contents of the capsule may irritate the mucous membranes of the mouth and pharynx.
    Duodart can be used to replace combination therapy with dutasteride and tamsulosin hydrochloride in order to facilitate treatment.
    Replacement of Duodart with dutasteride or tamsulosin hydrochloride in monotherapy is possible if clinically justified.

    Application features

    pregnant
    Contraindicated.
    Children
    Contraindicated.
    Drivers
    Carefully.

    Overdose

    dutasteride. According to clinical studies, in volunteers, single doses of dutasteride up to 40 mg / day (80 times higher than therapeutic) for 7 days did not cause concern about the safety of their use. In clinical studies, doses of dutasteride 5 mg/day were used for 6 months without additional adverse reactions compared with the use of dutasteride at a dose of 0.5 mg/day.
    There is no specific antidote, therefore, in case of a possible overdose, symptomatic and supportive therapy is carried out.
    Tamsulosin. There have been reports of acute overdose of tamsulosin hydrochloride at a dose of 5 mg, which resulted in acute arterial hypotension (systolic blood pressure 70 mm / Hg), vomiting and diarrhea, which were treated with fluid infusions, after which the patient felt relief on the same day. In case of acute arterial hypotension that occurs after an overdose of tamsulosin hydrochloride, support for the activity of the cardiovascular system should be provided. The patient in this condition should take a horizontal position in order to restore blood pressure and normalize the heart rate. If this does not help, plasma substitutes should be prescribed, and, if necessary, vasoconstrictors. It is necessary to monitor the function of the kidneys and carry out galopidrimuval therapy. Dialysis may not be effective because tamsulosin hydrochloride is almost completely bound to plasma proteins.
    In case of overdose, in order to prevent absorption, the patient must be induced to vomit. If large doses of the preparation  are taken, it is necessary to perform a gastric lavage, give activated charcoal and a laxative, such as sodium sulfate.

    Side effects

    From the immune system. Frequency unknown: allergic reactions, including rash, itching, urticaria, localized edema and angioedema.
    From the side of the psyche. Frequency unknown: depression.
    From the skin and subcutaneous tissue. Rarely alopecia (mainly loss of body hair), hypertrichosis.
    From the reproductive system and mammary glands. Frequency unknown: testicular pain and swelling.

    Interaction

    The study of the interaction of the preparation Duodart with other preparations  has not been conducted.

    Storage conditions

    Store at a temperature not exceeding 25°C.
    Keep out of the reach of children.
    Shelf life - 2 years.

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