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    3. Duxet 60mg 28 capsules — Made in Turkey — Free Delivery

    Duxet 60mg 28 capsules — Made in Turkey — Free Delivery


    Brand: Nobel Ilac San. Ve Tic. A.S.
    Product Code: Duxet
    Availability: In Stock
    $45.58
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    Product description 

    Duxet capsules are indicated for:
    • Treatment of major depressive disorder.
    • Treatment of diabetic peripheral neuropathic pain.
    • Treatment of generalized anxiety disorder.

    Compound

    Active ingredient: duloxetine;
    1 capsule contains duloxetine hydrochloride equivalent to duloxetine 30 mg or 60 mg
    Excipients: spherical sugar, hypromellose 603, sucrose, talc, triethyl citrate, hypromellose acetate succinate (AS-LF), ammonium hydroxide solution 25%, Opadry White 02A28361: hypromellose, titanium dioxide (E 171), talc;
    The composition of the gelatin capsule No. 3 for 30 mg titanium dioxide (E 171), indigo (E 132), gelatin;
    The composition of the gelatin capsule No. 1 for 60 mg titanium dioxide (E 171), indigo (E 132), iron oxide yellow (E172), gelatin.

    Contraindications

    Hypersensitivity to duloxetine or to any excipients of the preparation.
    Simultaneous use with non-selective irreversible MAO inhibitors (MAO) or for at least 14 days after stopping treatment with MAO inhibitors. Given the half-life of duloxetine, MAO inhibitors should not be administered for at least 5 days after discontinuation of duloxetine treatment.
    Simultaneous use with fluvoxamine, ciprofloxacin or enoxacin (strong inhibitors of CYP1A2) due to an increase in the concentration of duloxetine in the blood plasma.
    Unstable arterial hypertension, which can provoke a hypertensive crisis.
    End-stage renal failure (creatinine clearance <30 ml/min).
    Liver disease, which can lead to liver failure.
    Childhood.

    Mode of application

    Major depressive disorder. Duxet is prescribed at a dose of 60 mg 1 time per day, regardless of food intake.
    For some patients, a dose greater than 60 mg may be recommended, up to a maximum dose of 120 mg per day, which is divided into 2 doses. Doses greater than 120 mg have not been systematically evaluated.
    Diabetic peripheral neuropathic pain. The recommended starting dose is 60 mg once daily with or without food. For some patients, a dose greater than 60 mg 1 time per day, up to a maximum dose of 120 mg per day, which is divided into 2 doses, can be recommended.
    The therapeutic effect of the treatment is manifested within 2 months.
    Generalized anxiety disorder. The recommended starting dose is 30 mg once daily with or without food. Patients with insufficient effect of treatment, the dose should be increased to 60 mg per day. As a reason for the insufficient effect of treatment with a dose of 60 mg, an increase in the dose to 90 or 120 mg per day can be considered.
    The therapeutic effect of the treatment appears within 2-4 weeks.

    Application features

    pregnant
    The use of the preparation  during pregnancy is recommended only if the expected benefit to the pregnant woman outweighs the potential risk to the fetus.
    Children
    The safety and efficacy of duloxetine in children have not been studied, so the preparation is contraindicated in this age group of patients.
    Drivers
    During treatment, patients should refrain from potentially hazardous activities that require increased attention and speed of psychomotor reactions.

    Overdose

    Data on duloxetine overdose are limited. There are reports of taking large doses (up to 1400 mg) of duloxetine alone or in combination with other preparations, which did not have fatal outcomes. Overdose symptoms (mainly when combined with other preparations) included drowsiness, coma, serotonin syndrome, epileptic seizures, vomiting and tachycardia.
    Treatment. Specific antidotes are unknown. When serotonin syndrome occurs, specific treatment is necessary (using cyproheptadine and / or temperature control). Airway patency should be checked. Cardiac and vital signs monitoring is recommended, along with appropriate symptomatic and supportive measures. Gastric lavage may be appropriate if performed immediately after taking the preparation. Activated charcoal reduces the absorption of the preparation. Duloxetine has a large volume of distribution in the body, and therefore forced diuresis, hemoperfusion and exchange perfusion are unlikely to be useful.

    Side effects

    Dizziness, nausea and headache have been reported as adverse symptoms upon discontinuation of duloxetine. Sensory disturbances, sleep disturbances, agitation or anxiety, tremors, irritability, diarrhea, and hyperhidrosis have also been reported upon discontinuation of duloxetine.
    From the endocrine system: hypothyroidism.
    From the immune system: anaphylactic reactions, hypersensitivity.
    On the part of metabolism: decreased appetite, hyperglycemia, dehydration, hyponatremia, syndrome of inappropriate secretion of antidiuretic hormone.
    On the part of the psyche: insomnia, agitation, decreased libido, anxiety, abnormal visions and abnormal orgasm, sleep disorders, bruxism, disorientation, apathy, suicidal thinking, mania, hallucinations, aggression and malice, suicidal behavior.
    From the side of the nervous system: headache, drowsiness, dizziness, tremor, paresthesia, myoclonus, akathisia, nervousness, attention disorders, lethargy, dyskinesia, taste disturbances, restless legs syndrome, poor sleep, serotonin syndrome, convulsions, extrapyramidal disorders ..
    From the dock of the organs of vision: blurry image, mydriasis, visual disturbances, dry eyes, glaucoma.
    On the part of the hearing organs: ringing in the ears, vertigo, pain in the ears.
    From the side of the cardiovascular system: palpitations; tachycardia hot flashes; supraventricular arrhythmia; fibrillation, more often atrial; arterial hypertension; increased blood pressure; orthostatic hypotension; loss of consciousness; sensation of coldness in the extremities; hypertensive crisis.
    From the respiratory system: yawning, oropharyngeal pain, feeling of constriction in the throat, epistaxis.
    From the digestive tract: nausea, vomiting, dyspepsia, flatulence, abdominal pain, constipation, diarrhea, gastrointestinal bleeding, gastroenteritis, belching, gastritis, stomatitis, bad breath, blood in the stool, dry mouth.

    Interaction

    Preparations acting on the central nervous system. When taking duloxetine in combination with other preparations that act on the central nervous system, especially with a similar mechanism of action, including alcohol and sedative preparations, certain precautions must be observed.
    MAO inhibitors. Duloxetine should not be co-administered with nonselective irreversible MAOIs (MAOIs) due to the risk of serotonin syndrome. When taking reversible selective monoamine oxidase inhibitors (MAOIs), such as moclobemide, the risk of serotonin syndrome is less, but the use of this combination is not recommended.
    Medicines containing duloxetine. Co-administration with other medicinal products containing duloxetine should be avoided.
    Preparations containing St. John's wort. When used together with Duxet, adverse reactions often occur.

    Storage conditions

    Store below 25°C in original packaging.
    Keep out of the reach of children.
    Shelf life - 3 years.

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