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    3. Endofalk powder for oral solution 55.318 g x 6 sachets — Made in Germany — Free Delivery

    Endofalk powder for oral solution 55.318 g x 6 sachets — Made in Germany — Free Delivery


    Brand: Dr. Falk Pharma GmbH
    Product Code: Endofalk
    Availability: In Stock
    $28.81
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    Pharmacological properties

    Pharmacodynamics. Endofalk is a mixture of different electrolytes and macrogol to obtain an isotonic solution to cleanse the intestines.
    The pharmacodynamic effect is to induce diarrhea. The intestines are emptied and cleansed. The electrolytes contained in the ready-to-use solution are balanced so as to ensure that the reverse process of absorption and secretion of water and electrolytes in the digestive tract is stopped and there is virtually no pure flow. High molecular weight macrogol provides isoosmolar concentration, which is characterized by a concentration of particles comparable to that in blood plasma. This prevents any significant fluid changes between the bowel lumen and the vascular cavity. With this type of balancing and osmolarity, there is little to no effect on electrolyte or fluid balance in the body.
    Pharmacokinetics. Macrogol 3350 is an inert compound that undergoes only minimal absorption in the gastrointestinal tract and is not metabolized. The minimum amount of macrogol 3350, 1% of the administered dose, is excreted in the urine.

    Indications

    Bowel cleansing before colonoscopy.

    Application

    For a complete cleansing of the intestines, it is necessary to drink up to 3 liters, up to a maximum of 4 liters of endofalk solution. one sachet corresponds to 500 ml of solution.
    The solution is drunk in portions of 200-300 ml every 10 minutes, until the rectal washings become clear.
    The solution is usually taken about 4 hours before the start of the study. The total required amount can be drunk in the evening, on the eve of the study, or partially and the remainder - the next morning, on the day of the study.
    Patients should not eat solid food 2-3 hours before taking Endofalk and until the end of the study.
    Preparation of the solution
    The solution is prepared immediately before use. The contents of two sachets should be dissolved in 500 ml of warm or cooled boiled water and then brought to 1 liter with water. It is advisable to take the solution chilled.

    Contraindications

    Hypersensitivity to active substances, other macrogols or one of the ingredients in the composition of the preparation, intestinal obstruction established or suspected, gastrointestinal obstruction, gastrointestinal perforation, risk of gastrointestinal perforation, carcinoma and other severe inflammatory bowel diseases (in including ulcerative colitis, Crohn's disease), toxic megacolon, impaired gastric emptying.
    Endofalk should not be administered to patients with impaired consciousness or patients prone to aspiration or belching, with general weakness or impaired swallowing reflex.

    Side effects

    From the digestive system: often (≥1 / 100, 1/10) - vomiting, abdominal cramps, abdominal pain and irritation of the anus; very often (≥1 / 10) - nausea, fullness and bloating.
    These symptoms are more often noted due to the consumption of relatively large amounts of liquid over a short period of time. If gastrointestinal symptoms occur, the frequency of taking Endofalk should be temporarily reduced or discontinued until the undesirable symptoms disappear.
    General disorders: rarely (≥1 / 1000, 1/100) - general malaise and insomnia.
    From the side of the cardiovascular system: very rarely (1/10 000) - cardiac arrhythmia, tachycardia and pulmonary edema.
    On the part of laboratory parameters: very rarely (1/10 000), some patients may experience a decrease in the level of calcium, potassium, sodium in the blood plasma.
    From the side of the central nervous system: very rarely (1/10 000) - neurological disorders as a result of fluctuations in electrolyte balance can lead to mild disorientation or generalized seizures.
    From the immune system: very rarely (1/10 000) - urticaria, rhinorrhea; itching or dermatitis, probably of allergic origin; rash, Quincke's syndrome, anaphylactic shock.
    The literature provides data on two cases of Mallory-Weiss syndrome, noted as a result of vomiting after the use of solutions containing macrogol.

    Special instructions

    Endofalk is used in elderly patients and in persons with reflux esophagitis or arrhythmia with suspected or confirmed sinoatrial blockade or sick sinus syndrome only under medical supervision.
    The preparation can be used in patients with chronic inflammatory bowel processes (exception: severe stages of the disease and toxic megacolon), but with caution and, if possible, under medical supervision.
    Endofalk should not be used in patients with heart failure (grade III and IV according to NYHA), renal failure, liver disease, or in persons with severe dehydration, since the safety of use in these groups of patients has not been adequately studied. The preparation should be taken with caution in patients at risk of water-electrolyte imbalance (for example, patients with impaired liver and kidney function, while taking diuretics). Isolated cases of violations of water and electrolyte balance in patients at risk have been recorded. Patients with heart or renal failure may develop acute pulmonary edema due to excess sodium hydroxide intake.
    Do not add any other solutions or additives (in particular, sugar or flavors incompatible with Endofalk solution) to the Endofalk solution, ready for oral use, as this can change the osmolarity and electrolyte composition or cause increased gas formation in the intestine.
    It is necessary to monitor the water and electrolyte balance in patients at risk, including elderly patients and debilitated patients.
    During pregnancy and breastfeeding. Pregnancy. There is no experience of using the preparation during pregnancy.
    Breastfeeding period. There are no data on the intake of macrogol 3350 into breast milk. Macrogol 3350 is poorly absorbed. Endofalk can be used while breastfeeding if the benefits outweigh the potential risks.
    Children. Endofalk should not be used in children, since the safety of the preparation in this age group of patients has not been adequately studied.
    Influence on the ability to drive vehicles and work with other mechanisms. Endofalk does not affect the ability to drive vehicles or operate other mechanisms.

    Interactions

    Medicines used orally for several hours before or during the administration of endofalk can be eliminated from the gastrointestinal tract, or their absorption can be reduced or completely stopped. this applies in particular to modified release formulations. if, for health reasons, this preparation is absolutely necessary, you should replace the use of the oral form of the preparation with another dosage form or find an alternative.
    Interaction of macrogol with certain enzymatic tests (eg ELISA) may be noted in a diagnostic study of the intestinal fluid that has been excreted.
    The ready-made solution cannot be mixed with other solutions or additives.

    Overdose

    In case of overdose, severe diarrhea is possible. in the event of a significant overdose, the development of violations of the water, electrolyte and acid-base balance is possible. adequate fluid replacement and monitoring of plasma electrolytes and pH values ​​are necessary.
    If a fluid, electrolyte or acid-base imbalance occurs, it is also necessary to restore electrolytes and take measures to restore the acid-base balance.
    With aspiration, toxic pulmonary edema may develop, which requires immediate intensive therapy, including mechanical ventilation under high pressure.

    Storage conditions

    Does not require special storage conditions. ready-made solution is suitable for use within 3 hours when stored at temperatures up to 25 ° C or for 48 hours at a temperature of 2-8 ° C (in the refrigerator).

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