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    3. Felodip 10mg 30 tablets — Made in Germany — Free Delivery

    Felodip 10mg 30 tablets — Made in Germany — Free Delivery


    Brand: TEVA
    Product Code: Felodip 10mg
    Availability: In Stock
    $54.22
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    Indications

    Essential arterial hypertension prophylactic treatment of chronic stable angina pectoris.

    Application

    Arterial hypertension adults (including elderly patients): the dosing regimen is determined individually.
    Therapy begins with a dose of 5 mg 1 time per day. If necessary, the dose can be reduced to 2.5 mg or increased, or another antihypertensive preparation added. As a rule, the maintenance dose is 5-10 mg 1 time per day.
    Angina. The dosage regimen is always determined individually.
    Therapy begins with a dose of 5 mg 1 time per day. If necessary, this dose can be increased to 10 mg 1 time per day. The maximum dose is 20 mg / day.
    In patients with impaired renal function, changes in pharmacokinetics are insignificant, so dose adjustment is not required.
    In patients with hypertension and angina pectoris with severe hepatic impairment, the therapeutic dose of felodipine should be reduced (recommended dose 2.5 mg / day).
    For the elderly, an initial dose of 2.5 mg once daily may be sufficient.

    Method of application:

    the preparation is taken in the morning, before meals or after a light breakfast. Tablets are not chewed, divided or crushed. Tablets must be swallowed whole and washed down with water.

    Contraindications

    Allergic reaction to felodipine and other dihydropyridines (theoretical risk of cross-reactivity) or to other components of the preparation; decompensated heart failure; unstable angina; acute myocardial infarction; dynamic obstruction of the outflow tract of the left ventricle. clinically significant aortic stenosis.

    Side effects

    Like other calcium channel blockers, the preparation can cause flushing of the face, headache, palpitations, dizziness and fatigue. these reactions are temporary and often appear at the beginning of treatment and / or when the dose is increased. Also, depending on the dose, swelling in the ankles may occur, which is a consequence of precapillary vasodilation, and not a tendency to fluid retention in the body. in patients with gingival inflammation or periodontitis, gum abscess may occur. this can be avoided with proper oral hygiene. as with the use of other dihydropyridines, in rare cases, worsening of the manifestations of angina pectoris was noted, mainly at the beginning of treatment.
    The following side effects have been reported in clinical trials and post-registration preparation monitoring.
    From the immune system: hypersensitivity reactions (urticaria and angioedema).
    From the nervous system: headache, sleep disturbance, drowsiness, dizziness, paresthesia, anxiety, irritability, confusion, depression.
    From the respiratory system: shortness of breath, nosebleeds.
    From the side of the cardiovascular system: increased manifestations of angina pectoris (especially at the beginning of treatment), mainly in patients with symptomatic coronary artery disease, syncope, a feeling of increased heart rate, tachycardia, myocardial infarction. Peripheral edema (the degree of swelling in the ankles depends on the dose), arterial hypotension, leukocytoclastic vasculitis.
    From the reproductive system: sexual dysfunction.
    From the urinary system: frequent urination.
    From the digestive system: nausea, gingivitis, gum hyperplasia, abdominal pain, vomiting, periodontitis, diarrhea, constipation, dry mouth.
    From the side of liver and gallbladder function: increased levels of liver enzymes, cholestatic hepatitis.
    On the part of the skin and subcutaneous tissue: hyperemia, hot flashes (especially at the beginning of treatment, when a high dose is increased or injected), rash, itching, photosensitivity, angioedema, erythema multiforme, erythema nodosum.
    From the musculoskeletal system and connective tissue: arthralgia, myalgia, tremor.
    Systemic disorders and local reactions: increased fatigue, fever.

    special instructions

    As with other vasodilators, felodip can rarely cause severe hypotension with tachycardia, which in sensitive patients can lead to myocardial ischemia.
    The efficacy and safety of felodipine in the treatment of malignant hypertension has not been studied.
    Felodipine should be used with caution in patients with severe left ventricular dysfunction.
    Grapefruit juice increases peak plasma concentrations and bioavailability of the preparation, possibly due to interaction with flavonoids in fruit juice.
    The preparation contains lactose, so patients with rare hereditary forms of galactose intolerance, lactase deficiency or glucose-galactose malabsorption should not use this preparation.
    During pregnancy and breastfeeding. Felodipine is contraindicated in pregnancy.
    Felodipine can pass into breast milk, but it is not known whether it has a negative effect on newborns. However, due to limited data on the safety of the preparation in children who are breastfed, Felodipine should not be used during breastfeeding.
    Children. The preparation is not prescribed to children.

    Interactions

    The simultaneous use of substances that interact with the enzyme system of cytochrome p450 3a4 may affect the levels of felodipine in blood plasma.
    Enzyme inhibitors such as cimetidine, ranitidine, erythromycin, itraconazole, ketoconazole, ritonavir, saquinavir and quinidine increase the plasma concentration of felodipine, so it may be necessary to reduce its dose while using these preparations.
    Enzyme inducers such as phenytoin, carbamazepine, rifampicin, barbiturates, and St. John's wort (hypericum perforatum) may reduce plasma concentrations of felodipine, so higher doses than recommended may be required in patients taking this preparation.
    Felodipine may increase the concentration of tacrolimus. In the case of simultaneous use of felodipine and tacrolimus, it is necessary to monitor the concentration of tacrolimus in the blood plasma and adjust the dose accordingly.
    Grapefruit juice increases the plasma levels of felodipine, as well as its bioavailability due to the presence of flavonoids in it, so it should not be used simultaneously with felodipine.
    Antihypertensive preparations prolong the hypotensive effect of felodipine.
    Sympathomimetics reduce the effect of felodipine.
    Dose adjustment is not required when felodipine is co-administered with digoxin.
    Felodipine does not affect the proportion of free fractions of other preparations that are characterized by significant binding to plasma proteins, such as warfarin.

    Overdose

    May cause excessive peripheral vasodilation with severe hypotension, which can sometimes be accompanied by bradycardia.
    Treatment. In severe arterial hypotension, symptomatic treatment is indicated. The patient should be placed in a horizontal position with legs raised up. With bradycardia, atropine 0.5–1 mg is administered. If this is not enough, it is necessary to replenish the BCC with an infusion, for example, dextrose, 0.9% sodium chloride solution, polyglucin. You can prescribe sympathomimetics with a predominant effect on α1-adrenergic receptors.

    Storage conditions

    At a temperature not higher than 25 ° C.

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