Hepametion lyophilisate for solution for injection, 400mg 5 vials, complete with solvent 5ml x 5 ampoules — Made in Ukraine — Free Delivery

S-adenosyl-L-methionine (ademetionine) is a natural amino acid that is present in almost all tissues and fluids of the body. Ademethionine mainly acts as a coenzyme and methyl group donor in transmethylation reactions, which is a necessary metabolic process in humans and animals. The transfer of methyl groups (transmethylation) is also a necessary metabolic process during the construction of a double phospholipid layer in cell membranes and promotes membrane fluidity.

Ademetionine is able to penetrate the blood-brain barrier. The transmethylation process involving ademetionine is key in the formation of central nervous system neurotransmitters, including catecholamines (dopamine, norepinephrine, adrenaline), serotonin, melatonin, and histamine.

Ademetionine is also a precursor in the formation of physiological sulfonated compounds (cysteine, taurine, glutathione, coenzyme A, etc.) in transsulfurization reactions. Glutathione, a powerful antioxidant in the liver, plays an important role in liver detoxification. Ademetionine increases the level of hepatic glutathione in patients with liver damage of both alcoholic and non-alcoholic genesis. Folic acid (folates) and vitamin B 12 are essential contributors to the metabolism and recovery of ademetionine.

Intrahepatic cholestasis in adults, including patients with chronic hepatitis of various etiologies and liver cirrhosis.

Intrahepatic cholestasis in pregnant women.

Depressive syndromes.

Genetic defects affecting the methionine cycle and / or causing homocystinuria and / or hyperhomocysteinemia (for example, deficiency of cystathionine beta synthase, defect in vitamin B 12 metabolism).

Hypersensitivity to any component of the preparation.

Method of administration and dosage

Treatment can begin with parenteral administration of the preparation followed by the use of the preparation in the form of tablets or immediately after the use of tablets. The daily dose of tablets can be divided into 2-3 doses. It is necessary to prepare a solution for injection immediately before use.

Initial therapy

Intravenous or intramuscular: the recommended dose is 5–12 mg / kg of body weight per day. The usual starting dose is 400 mg / day, the total daily dose should not exceed 800 mg. The duration of initial parenteral therapy is 15–20 days in the treatment of depressive syndromes and 2 weeks in the treatment of liver diseases.

Orally (inside): for oral administration, the ademetionine preparation should be used in the form of tablets. The recommended dose is 10-25 mg / kg of body weight per day. The initial dose is 800 mg / day (2 tablets), the total daily dose should not exceed 1600 mg (4 tablets).

Supportive therapy

Administered orally, 2–4 tablets per day (800–1600 mg / day).

The duration of therapy depends on the severity of the course of the disease and is determined by the doctor individually.

For intramuscular or intravenous use, dissolve the lyophilized powder in the special supplied solvent immediately before use. For administration, the required dose of ademetionine must be further diluted in 250 ml of saline or 5% glucose (glucose) solution and infused slowly over 1–2 hours. Discard the unused portion of the solution.