The preparation Kerawort is indicated for local treatment:
Active ingredient: Imiquimod;
1 sachet (250 mg cream) contains imiquimod 12.5 mg;
Excipients: sorbitan stearate, isostearin acid, cetyl alcohol, stearyl alcohol, white soft paraffin, polysorbate 60, methylparaben (E 218), propylparaben (E 216), glycerin, xanthan gum, benzyl alcohol, purified water.
Hypersensitivity to imiquimod or to any other components of the preparation.
Imiquimod cream should be applied three times a week (for example Monday, Wednesday and Friday or Tuesday, Thursday and Saturday) before bed and left on the skin for 6 to 10 hours. Treatment with imiquimod cream should be continued until genital and perianal warts disappear, but no more than 16 weeks after warts appear.
The cream should be applied in a thin layer and rubbed into the clean surface of the areas affected by genital warts until completely absorbed. The cream should only be applied to the affected areas. Shower or bath should be avoided for 6 to 10 hours after applying the cream to the skin. After the specified period, the cream must be washed off with warm water and soap. Excessive application of cream or prolonged skin contact may cause a reaction at the site of application. A cream with one sachet is enough to apply 20 cm2 to a skin area. Do not reuse the cream from the previously opened sachet. Before and after applying the cream, wash your hands with warm water and soap.
Men who have not undergone circumcision, when treating genital warts under the foreskin, should move the foreskin and wash the area under it daily.
Pregnant
Use during pregnancy or lactation is not recommended.
If it is necessary to use the preparation, breastfeeding should be discontinued.
Children
Contraindicated in children under 18 years of age.
Drivers
During treatment, care should be taken when driving vehicles or working with other mechanisms, as well as performing work requiring increased concentration of attention, for the possible appearance of weakness, dizziness.
Overdose is unlikely due to low absorption of the preparation. Permanent overdose with topical application of the cream can cause severe local skin reactions.
In case of accidental ingestion of a dose of 200 mg imiquimod, which corresponds to a content of about 16 sachets, nausea, vomiting, headache, myalgia and fever may occur. The most clinically serious side effect of oral administration of multiple doses of 200 mg is hypotension, which disappeared after oral or intravenous fluid therapy.
When applying the cream 3 times a week, frequent adverse reactions were reactions at the site of application of the cream, namely, erythema, erosion, peeling and edema. Several systemic adverse reactions have also been observed, such as headache, flu-like symptoms, and muscle pain.
Delayed skin reactions, mainly erythema, have also been observed in unaffected areas that may have been in contact with imiquimod cream. Most of these reactions disappeared within 2 weeks after the end of treatment. However, in some cases, these reactions were severe and caused dysuria in women.
The interaction of imiquimod with other preparations has not been studied. Since imiquimod stimulates the immune system, the cream should be used with caution in patients receiving immunosuppressive preparations.
Minimal absorption through the skin should limit interactions with systemic preparations.
Store at a temperature not exceeding 25 ° C. Do not freeze.
Keep out of the reach of children.
Shelf life is 2 years.
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