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    3. Letrozole-Teva 2.5 mg 30 capsules — Made in Hungary — Free Delivery

    Letrozole-Teva 2.5 mg 30 capsules — Made in Hungary — Free Delivery


    Brand: TEVA
    Product Code: Letrozole-Teva
    Availability: In Stock
    $42.21
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    Product description

    Letrozole-Vista film-coated tablets are indicated for:
    • Adjuvant therapy for hormone-positive invasive breast cancer in early stages in postmenopausal women.
    • Advanced adjuvant therapy for early invasive breast cancer in postmenopausal women who have received standard adjuvant tamoxifen therapy for 5 years.
    • First-line therapy for hormone-dependent advanced breast cancer in postmenopausal women.
    • Treatment of common forms of breast cancer in postmenopausal women (natural or induced) after relapse or progression of the disease, who received previous antiestrogen therapy.
    • Neoadjuvant therapy in postmenopausal women with hormone-positive, HER-2-negative breast cancer who are unsuitable for chemotherapy and are not indicated for urgent surgery.

    Structure

    Active substance: letrozole;
    1 tablet contains letrozole 2.5 mg;
    Excipients: microcrystalline cellulose, corn starch, magnesium stearate, lactose, colloidal silicon dioxide, sodium starch (type A), yellow iron oxide (E 172), polyethylene glycol, titanium dioxide (E 171), talc, indigo (E 132), polyvinyl alcohol, tartrazine (E 102).

    Contraindications

    Hypersensitivity to the active substance or to any other component of the drug.
    Endocrine status characteristic of the premenopausal period.
    Pregnancy, lactation period.
    Women of reproductive age.

    Mode of application

    The drug should be taken orally with or without food, since food does not affect absorption.
    The missed dose should be taken as soon as the patient remembers it. However, if the patient remembers this shortly before taking the next dose (2-3 hours), the missed dose should be skipped and the next dose should be taken according to the schedule. Do not take a double dose, because when taking a daily dose higher than the recommended 2.5 mg, a systemic exposure higher than the proportional one was observed.

    Application features

    Pregnant
    Not applicable.
    Children
    Not applicable.
    Drivers
    The effect of letrozole on the ability to drive vehicles and operate machinery is negligible. Since during the treatment with the drug in patients there was general weakness and dizziness, in some cases - drowsiness, patients should be warned that when these symptoms occur, they should refuse to drive vehicles or work with mechanisms.

    Overdose

    Reported isolated cases of drug overdose.
    The specific treatment for overdose is unknown; treatment should be symptomatic and supportive.

    Side effects

    Fatigue (including asthenia, malaise), peripheral edema, chest pain, fever, dry mucous membranes, thirst, generalized edema.

    Interaction

    Inhibitors of the activity of CYP3A4 and CYP2A6 can reduce the metabolism of letrozole and, thus, increase the concentration of letrozole in the blood plasma. The simultaneous use of drugs that strongly inhibit these enzymes (powerful inhibitors of CYP3A4 include, but are not limited to: ketoconazole, itraconazole, voriconazole, ritonavir, clarithromycin and telithromycin; CYP2A6 (for example, methoxalen)) may increase the exposure of letrozole. Therefore, patients who are shown potent inhibitors of CYP3A4 and CYP2A6 are advised to exercise caution when using them.

    Storage conditions

    Keep out of the reach of children. The drug does not require special storage conditions.
    Shelf life is 3 years.

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