Amantin tablets are used for the following indications:
The active ingredient is amantadine sulfate (one tablet contains 100 mg amantadine sulfate).
Excipients: lactose monohydrate, microcrystalline cellulose, potato starch, gelatin, povidone, croscarmellose sodium, talc, colloidal anhydrous silicon dioxide, magnesium stearate, Opadry II White (polyethylene glycol, polyvinyl alcohol, talc (E1) dioxide).
The tablets should be taken by adults by mouth, with a small amount of liquid, after meals, preferably in the morning and / or afternoon. Due to the possible activating effect on the central nervous system (CNS), the last dose is recommended to be taken no later than sixteenth hour.
By following the aforementioned measures and taking into account the contraindications, it is possible to prevent a life-threatening adverse reaction - chaotic polymorphic ventricular tachycardia.
Treatment of patients with Parkinson's syndrome and movement disorders caused by the use of preparations should be carried out gradually, observing the dosage in accordance with the therapeutic effect.
Treatment should begin with taking one tablet (100 mg of amantadine sulfate) of the preparation "Amantin" per day in the first 4-7 days, followed by an increase in the daily dose by one tablet once a week until an effective therapeutic dose is reached.
The usual effective dose is 1-3 tablets twice a day (200-600 mg amantadine sulfate).
Elderly patients, in particular with states of agitation, confusion or delirium syndromes, are recommended a daily dose of 100 mg (one tablet). If this dose is not effective, it can be carefully increased to 200 mg per day under medical supervision.
When combined treatment with other antiparkinsonian preparations, the dose should be selected individually.
For patients who have previously been treated with amantadine, injection solution, the starting dose should be higher.
With a sharp deterioration in parkinsonian symptoms in an akinetic crisis, it is necessary to prescribe the administration of a solution of amantadine sulfate.
The duration of treatment depends on the nature and severity of the disease and is determined by the doctor. Patients should not interrupt treatment on their own.
Abrupt discontinuation of treatment should be avoided, since in this case, in patients with Parkinson's disease, extrapyramidal symptoms may increase, which sometimes include an akinetic crisis, and the effect of discontinuation can sometimes manifest itself in the form of delirium.
Pregnant
Amantadine is contraindicated for pregnant women and women planning pregnancy. The preparation is contraindicated during lactation as it passes into breast milk. If it is necessary to use the preparation, breastfeeding should be discontinued.
Children
The experience of using amantadine for children is insufficient, therefore the preparation is not used in this age category.
Drivers
Amantadine can reduce concentration and response speed, cause dizziness, decreased visual acuity, therefore, patients should be warned of the potential danger when driving or when working with other mechanisms.
It is always necessary to consider the possibility of repeated intoxication, for example, taking more than one preparation for the purpose of suicide.
Symptoms of acute toxic psychosis in the form of confusion with visual hallucinations, which sometimes include coma and myoclonus and can be observed after concomitant administration of amantadine and other antiparkinsonian preparations, occupy a significant place with an overdose of amantadine.Excessive agitation, tremor, ataxia, blurred vision, lethargy, depression, dysarthria, neuromuscular disorders, hyperreflexia, motor restlessness, convulsions, extrapyramidal phenomena, torsion spasms, dilated pupils, dysphagia, confusion, disorientation, delirium, myoclonus, toxoid vomiting, dry mouth, hyperventilation, pulmonary edema, respiratory failure, respiratory distress syndrome, hypertension, cardiac arrhythmia, tachycardia, angina attacks, cardiac arrest. Possible renal dysfunction, including an increase in urea nitrogen and a decrease in creatinine clearance, urinary retention.
Treatment
No specific preparation treatment or antidote is known. To prevent absorption of the preparation, it is necessary to induce vomiting and / or rinse the stomach (if the patient is conscious), apply activated charcoal. In case of life-threatening intoxication, resuscitation measures are necessary. It is necessary to take therapeutic measures, ensure the maintenance of vital body functions, adequate hydration, possibly sedation, measures against seizures and arrhythmias.
Adverse reactions to amantadine, which are often mild and transient, usually appear within 2-4 days from the start of treatment and quickly disappear after stopping the preparation.
From the side of the psyche: often (> 1/100 to <1/10) - sleep disturbance and mental agitation.
From the nervous system: often (> 1/100 to <1/10) - movement disorders.
From the vascular system: often (> 1/100 to <1/10) - orthostatic dysregulation.
From the digestive tract: often (> 1/100 to <1/10) - nausea, dry mouth.
On the part of the skin and subcutaneous tissue: often (> 1/100 to <1/10) - "marbled" skin (the appearance of a bluish reticular skin tone), sometimes associated with swelling of the ankle joint.
From the genitourinary system: often (> 1/100 to <1/10) - urinary retention in patients with prostatic hyperplasia, urinary incontinence, changes in libido.
Store in its original packaging at a temperature not exceeding 25 ° C, out of the reach of children.
Shelf life is 3 years.
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