Film-coated tablets Limistin 40 are indicated for:
Active substance: atorvastatin;
1 tablet contains atorvastatin calcium in terms of atorvastatin 10 mg or 20 mg, 40 mg;
Excipients: calcium carbonate; microcrystalline cellulose lactose monohydrate, croscarmellose sodium; polysorbate 80 hydroxypropyl cellulose; magnesium stearate hydroxypropyl methylcellulose; propylene glycol; polyethylene glycol-6000; talc titanium dioxide (E 171) - tablets of 10 mg and 20 mg
Calcium carbonate; microcrystalline cellulose lactose monohydrate, croscarmellose sodium; polysorbate 80 hydroxypropyl cellulose; magnesium stearate crospovidone; sodium lauryl sulfate; hydroxypropyl methylcellulose; polyethylene glycol-6000; talc titanium dioxide (E 171) - 40 mg tablets.
Active liver disease, which may include a sustained increase in hepatic transaminase activity of unknown etiology.
Hypersensitivity to any of the components of this medication.
Before starting therapy with atorvastatin, the level of hypercholesterolemia should be determined against the background of an appropriate diet, exercise and measures aimed at reducing body weight in obese patients should be prescribed, and other diseases should be treated. During treatment with atorvastatin, patients should follow a standard low-cholesterol diet. Use the preparation in a dose of 10-80 mg once a day every day, at any time of the day, regardless of food intake. The starting and maintenance dose can be individualized according to the starting level of LDL-C, the goals of therapy and its effectiveness. 2-4 weeks after the start of treatment and / or dose adjustment of atorvastatin, the lipid profile should be determined and the dose adjusted accordingly.
Pregnant
Not applicable.
Children
From 10 years old.
Drivers
Has a very insignificant effect on the reaction rate when driving or working with other mechanisms.
There is no specific treatment for atorvastatin overdose. In case of an overdose, the patient should be treated symptomatically and supportive measures should be taken if necessary. Due to the high degree of binding of the preparation to plasma proteins, one should not expect a significant increase in the clearance of atorvastatin using hemodialysis.
Atorvastatin is generally well tolerated.
Adverse reactions include: chest pain, facial edema, fever, asthenia, stiff neck muscles, weakness, photosensitivity, generalized edema, malaise, pyrexia, peripheral edema.
The risk of developing myopathy during treatment with statins increases with the simultaneous use of fibric acid derivatives, lipid-modifying doses of niacin, cyclosporine, or potent inhibitors of CYP 3A4 (for example, clarithromycin, HIV protease inhibitors and itraconazole).
Grapefruit juice. Contains one or more components that inhibit CYP 3A4 and can increase plasma concentrations of atorvastatin, especially with excessive consumption of grapefruit juice (more than 1.2 liters per day).
Atorvastatin and its metabolites are substrates for the OATP1B1 transporter. OATP1B1 inhibitors (eg cyclosporin) can increase the bioavailability of atorvastatin. The AUC value of atorvastatin significantly increased with the simultaneous use of atorvastatin at a dose of 10 mg and cyclosporin at a dose of 5.2 mg / kg / day compared with the use of atorvastatin alone. The simultaneous use of atorvastatin and cyclosporine should be avoided.
Store in its original packaging at a temperature not exceeding 30 ° C.
Keep out of the reach of children.
Shelf life is 2 years.
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