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    3. Medogistin 16mg 30 tablets — Made in Cyprus — Free Delivery

    Medogistin 16mg 30 tablets — Made in Cyprus — Free Delivery


    Brand: Medochemie
    Product Code: Medogistin
    Availability: In Stock
    $20.72
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    Indications

    • Meniere's disease and syndrome, characterized by three main symptoms:
    • dizziness, which is sometimes accompanied by nausea and vomiting;
    • hearing loss (hard of hearing);
    • tinnitus.
    • Symptomatic treatment of vestibular vertigo of various origins.

    Application

    The daily dose for adults is 24-48 mg, evenly distributed throughout the day.
    16 mg tablets take ½-1 tablet 3 times a day. 24 mg tablets take 1 tablet 2 times a day.
    It is advisable to take the tablets after meals. The dose should be selected individually, depending on the effect. A decrease in the severity of symptoms is sometimes noted only after 2-3 weeks of treatment. The best results are achieved when taking the preparation for several months. There is evidence that treatment early in the disease prevents disease progression and/or hearing loss in later stages.
    Elderly patients. Although there are currently limited clinical trial data in this patient population, extensive post-marketing experience suggests that dose adjustment is not required in this patient population.
    Renal failure. In this group of patients, special clinical trials have not been conducted, but in accordance with the experience of post-registration use, dose adjustment is not required.
    Liver failure. In this group of patients, special clinical trials have not been conducted, but in accordance with the experience of post-registration use, dose adjustment is not required.

    Contraindications

    Hypersensitivity to any of the components of the preparation. pheochromocytoma.

    Side effects

    The following adverse reactions are classified by frequency: very often (≥1 / 10), often (from ≥1 / 100 to 1/10), infrequently (from ≥1 / 1000 to 1/100), rarely (from ≥ 1 / 10,000 up to 1/1000), very rarely (1/10,000).
    Gastrointestinal disorders: often - nausea and dyspepsia.
    Nervous system disorders: often - headache. The incidence of headache in the placebo group (5.9% of 457 patients) was similar to that in the betahistine group (5.1% of 468 patients).
    Except for cases reported during clinical trials, the following side effects have been reported spontaneously during post-marketing use and in the scientific literature. Based on the available data, the frequency cannot be determined, so it is classified as unknown.
    Immune system disorders. Hypersensitivity reactions, including immediate type (for example, cases of anaphylaxis have been reported).
    Gastrointestinal disorders. Complaints of minor indigestion (vomiting, pain along the gastrointestinal tract, pain in the abdominal region due to bloating and flatulence). These side effects usually disappear when the preparation is taken with food or when the dose is reduced.
    Changes in the skin and subcutaneous tissue. Hypersensitivity reactions of the skin and subcutaneous fat have been observed, in particular angioedema, rash, itching and urticaria.

    special instructions

    During treatment with the preparation, it is necessary to carefully monitor the condition of patients with asthma and / or a history of gastric ulcer and duodenal ulcer.
    The preparation contains lactose, so it should not be used in patients with rare hereditary forms of galactose intolerance, lactase deficiency or glucose-galactose malabsorption syndrome.
    The ability to influence the reaction rate when driving vehicles or working with other mechanisms. Betahistine, according to clinical studies, has no significant effect or effects that affect the ability to drive and operate machines.
    Use during pregnancy or lactation. There are no data on the use of betahistine in pregnant women. Since studies of reproductive toxicity in animals do not always allow us to assess the possibility of toxic effects on pregnancy, embryo / fetus development, childbirth and postnatal development in humans, the preparation should be taken only if there is an undeniable need and under the direct supervision of a physician.
    The penetration of betahistine into breast milk has not been studied. The benefit to the mother should be weighed against the benefits of breastfeeding and the potential risk to the baby.
    Children. Due to the lack of data on the safety and efficacy of the preparation, it is not recommended to prescribe the preparation to children.

    Interactions

    In vivo studies aimed at studying interactions with other preparations have not been conducted. Based on in vitro data, no inhibition of p450 cytochrome enzyme activity is expected in vivo.
    In vitro data suggest that betahistine metabolism is inhibited by preparations that inhibit MAO activity, including MAO subtype B (eg seleginine). Caution is advised when using betahistine and MAO inhibitors (including selective MAO subtype B) concomitantly.
    Since betahistine is a histamine analogue, the interaction of betahistine with antihistamines could theoretically affect the effectiveness of one of these preparations.

    Overdose

    There are several cases of preparation overdose. some patients experienced mild to moderate symptoms (nausea, drowsiness, abdominal pain) after taking the preparation at a dose of up to 640 mg. more serious complications (convulsions, cardiopulmonary complications) have been observed with the deliberate intake of high doses of betahistine, especially in combination with an overdose of other preparations.
    Treatment of overdose should include symptomatic therapy.

    Storage conditions

    At a temperature not exceeding 25 ° C in the original packaging.

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