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    3. Medulac, syrup 667mg/ml 180ml — Made in Italy — Free Delivery

    Medulac, syrup 667mg/ml 180ml — Made in Italy — Free Delivery


    Brand: ABC Farmaceutici S.p.A
    Product Code: Medulac
    Availability: In Stock
    $25.34
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    Pharmacological properties

    Pharmacodynamics. In the colon, lactulose is broken down by the intestinal microflora to low molecular weight organic acids. these acids reduce the pH in the lumen of the colon and, due to the osmotic effect, increase the volume of intestinal contents. this stimulates the peristalsis of the large intestine and normalizes the consistency of feces. constipation is corrected, and the physiological rhythm of digestion is restored.
    In portosystemic encephalopathy or hepatic (pre) coma, the effect of the preparation is due to inhibition of the growth of proteolytic bacteria due to an increase in the number of acidophilic bacteria (for example lactobacilli), the transformation of ammonia into an ionized form due to acidification of intestinal contents, bowel cleansing due to low pH, as well as the osmotic effect, a change in bacterial nitrogen metabolism by stimulating the utilization of ammonia by bacteria for the synthesis of bacterial proteins. Considering the above, it is necessary, however, to note that the neuropsychiatric manifestations of portosystemic encephalopathy cannot be explained by hyperammonemia alone. However, the described mechanism for reducing the level of ammonia by lactulose can be similar for other nitro compounds.
    Lactulose as a prebiotic enhances the growth of beneficial bacteria such as bifidobacteria and lactobacilli, while the growth of potentially pathogenic bacteria such as clostridia and E. coli is suppressed. This can lead to a more favorable balance of the intestinal flora.
    Pharmacokinetics. Lactulose is almost not absorbed after oral administration and reaches the intestines unchanged. When used in a dose of 25-50 g or 40-75 ml, lactulose is completely metabolized by the bacterial flora. When using high doses, some may be excreted unchanged.

    Indications

    Constipation: regulation of the physiological rhythm of the intestine; conditions requiring relief of bowel movements (hemorrhoids, after operations on the colon and anorectal zone); portosystemic hepatic encephalopathy: treatment and prevention of hepatic coma and precoma.

    Application

    The preparation is intended for oral administration. syrup can be taken both diluted and undiluted.
    The dose must be adjusted according to the individual needs of the patient.
    A single dose of the preparation should be swallowed immediately and not kept in the mouth for a long time.
    If the preparation is prescribed to the patient once a day, the dose should be taken at the same time of the day, for example, during breakfast.
    During therapy with laxatives, it is recommended to consume a sufficient amount of liquid (1.5-2 liters, which corresponds to 6-8 glasses) per day.
    For dosing, use a tablespoon (15 ml) or a teaspoon (5 ml).
    Use for constipation or for softening stools for medical purposes. It is necessary to take a single daily dose of the preparation or divide it into 2 doses.
    After a few days, the starting dose can be adjusted to a maintenance dose based on the response to treatment. It may take several days of therapy (2-3 days) before the therapeutic effect is manifested.
    AgeInitial dose (per day), mlMaintenance dose (per day), ml
    Adults and children under the age of 1415–4515-30
    Children aged 7-141510-15
    Children aged 1-65-105-10
    Children under 1 year oldup to 5up to 5
    As a rule, the dose can be reduced after 2 days of use, depending on the patient's needs.
    Conditions requiring softening of stool and facilitating bowel movements.
    The dosage and method of administration are the same as for constipation.
    Hepatic coma and precoma.
    The initial dose for adults is 30-45 ml 3-4 times a day. The maintenance dose is selected in such a way as to achieve two or three "soft" stools per day. Treatment can last three months or more.
    In case of impossibility of oral administration, the preparation is prescribed in the form of enemas
    (300 ml of the preparation is mixed with 700 ml of water or saline).

    Overdose.

    Symptoms: possible diarrhea, abdominal pain.
    Treatment: dose reduction or discontinuation of the preparation.

    Side effects.

    In the first days of treatment, flatulence may occur, which disappears after a few days. When taking the preparation in doses higher than recommended, abdominal pain and diarrhea may occur. In this case, the dose should be reduced. During the use of high therapeutic doses for a long time (usually in patients with hepatic insufficiency and encephalopathy), electrolyte imbalance may occur due to diarrhea.
    Gastrointestinal disorders: flatulence, abdominal pain, nausea and vomiting; diarrhea (at too high doses).
    Differences in laboratory characteristics: electrolyte imbalance due to diarrhea.
    Interaction with other medicinal products and other types of interactions.
    The simultaneous use of antibiotics and antacids with medulac reduces its effectiveness.
    With the simultaneous use of the preparation Medulac with enteric preparations
    By pH dependent release, it should be borne in mind that lactulose lowers the pH of the intestinal contents and alters the release of these preparations.
    Best before date. 3 years.
    The shelf life after the first opening is 12 months.

    Storage conditions.

    Store at temperatures up to 25 ° C, protected from light and out of reach of children.

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