Metformin-Teva 1000 mg is a potent, high-dose oral hypoglycemic preparation belonging to the biguanide class. It is specifically formulated to manage Type 2 Diabetes Mellitus in patients whose blood glucose levels are not adequately controlled by diet and physical exercise alone. This medication is the gold standard first-line therapy for patients with excess body weight, as it effectively reduces long-term diabetic complications. Metformin-Teva 1000 mg can be used as a standalone monotherapy or as part of a complex treatment plan involving other oral antidiabetics or insulin for adults and children over 10 years of age.
Each film-coated tablet is manufactured to high pharmaceutical standards:
Active Substance: Metformin hydrochloride — 1000 mg.
Excipients: Povidone K-30, anhydrous colloidal silicon dioxide, magnesium stearate.
Film Coating (White Opadry Y-1-7000): Hypromellose, titanium dioxide (E 171), and macrogol.
Metformin-Teva 1000 mg lowers blood glucose through three targeted biological mechanisms that do not involve stimulating additional insulin production:
Hepatic Control: It significantly reduces the liver’s production of glucose by inhibiting gluconeogenesis and glycogenolysis.
Muscle Sensitivity: It enhances the peripheral sensitivity of skeletal muscles to insulin, allowing for more efficient glucose uptake and utilization.
Absorption Modulation: It delays the absorption of glucose within the intestinal tract.
Because it does not trigger insulin secretion, it has a very low risk of causing hypoglycemia when used alone and is often "weight-neutral," helping overweight patients stabilize or lose weight.
Type 2 Diabetes Mellitus: Primary treatment for adults and adolescents (10+ years).
Overweight Management: First-line therapy to reduce vascular and metabolic complications.
Combined Therapy: Effective when paired with insulin or other oral hypoglycemic drugs.
Hypersensitivity to metformin or any tablet components.
Severe Renal Impairment: Glomerular filtration rate (GFR) < 30 ml/min.
Metabolic Acidosis: Including acute lactic acidosis or diabetic ketoacidosis.
Hypoxia Risks: Decompensated heart failure, respiratory failure, or recent myocardial infarction.
Acute Conditions: Dehydration, severe infections, or shock.
Liver Health: Liver failure, acute alcohol intoxication, and alcoholism.
Adults:
Initial Dose: Usually 500 mg or 850 mg (using appropriate strengths) 2–3 times daily.
Titration: Adjust after 10–15 days based on blood glucose levels.
Maximum Dose: 3000 mg per day, divided into 3 doses.
Children (10+ Years):
Initial Dose: 500 mg or 850 mg once daily.
Maximum Dose: 2000 mg per day, divided into 2–3 doses.
Meal Coordination: Always take your tablets during or after meals to minimize digestive discomfort.
Swallowing: High-dose 1000 mg tablets should be swallowed whole with water.
Gastrointestinal (Very Common): Nausea, vomiting, diarrhea, abdominal pain, and loss of appetite. These usually occur at the start of treatment and fade away.
Nervous System: Taste disturbances (metallic taste).
Metabolic: Rare risk of Lactic Acidosis. Long-term use may slightly decrease Vitamin B12 absorption.
Lactic Acidosis: A medical emergency characterized by muscle cramps and weakness. Avoid excessive alcohol and dehydration.
Pregnancy: While metformin is safe, switching to insulin is typically recommended to achieve the strictest possible blood sugar control for fetal health.
Breastfeeding: Not recommended as metformin is excreted in breast milk.
Driving: Safe in monotherapy; however, caution is required if combined with insulin or sulfonylureas due to potential hypoglycemia.
No special temperature storage conditions are required.
Keep out of the reach of children.
Shelf Life: 3 years.
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