Metformin-Teva 850 mg is a highly effective oral hypoglycemic agent, excluding insulin, categorized as a biguanide. It serves as a cornerstone in the management of Type 2 Diabetes Mellitus (T2DM), particularly when dietary therapy and physical activity are insufficient to maintain glycemic control. This medication is especially beneficial for patients with excess body weight, as it is clinically proven to reduce diabetic complications when used as a first-line therapy. Whether used as a monotherapy or in combination with other oral hypoglycemic agents or insulin, Metformin-Teva provides a reliable mechanism for stabilizing blood sugar levels in both adults and pediatric populations from the age of 10.
Each film-coated tablet of Metformin-Teva is formulated with precision:
Active Substance: Metformin hydrochloride — 850 mg.
Core Excipients: Povidone K-30, colloidal anhydrous silicon dioxide, magnesium stearate.
Film Coating: Hypromellose (2910/5), titanium dioxide (E 171), and macrogol (type 400).
Metformin-Teva operates through three distinct biological pathways to lower blood glucose without stimulating the production of additional insulin:
Hepatic Control: It significantly suppresses glucose production in the liver by inhibiting gluconeogenesis and glycogenolysis.
Muscle Sensitivity: It enhances the body's sensitivity to insulin, facilitating more efficient glucose uptake and utilization by skeletal muscles.
Intestinal Modulation: It delays the absorption of glucose within the gastrointestinal tract.
By avoiding the stimulation of insulin secretion, metformin does not cause hypoglycemia in monotherapy and helps maintain a stable weight or even promote modest weight loss.
Type 2 Diabetes Mellitus: Management in adults and children/adolescents aged 10 and older.
Overweight Patients: Indicated as a first-line preparation to reduce long-term diabetic complications.
Versatile Therapy: Can be used alone (monotherapy) or integrated into combined regimens with insulin or other oral antidiabetic drugs.
Hypersensitivity to metformin hydrochloride or any auxiliary substances.
Acute Metabolic Acidosis: Including lactic acidosis and diabetic ketoacidosis.
Severe Renal Impairment: Glomerular filtration rate (GFR) < 30 ml/min.
Acute Conditions: Dehydration, shock, or severe infectious diseases that risk kidney dysfunction.
Hypoxia-inducing Diseases: Decompensated heart failure, respiratory failure, or recent myocardial infarction.
Hepatic Issues: Liver failure, acute alcohol intoxication, and chronic alcoholism.
Adults:
Initial Dose: Usually 500 mg or 850 mg taken 2–3 times daily.
Titration: After 10–15 days, the dose should be adjusted based on serum glucose results.
Maximum Dose: 3000 mg per day, divided into 3 doses.
Switching: When transitioning from another agent, stop the previous drug before starting metformin.
Children (10+ years) and Adolescents:
Monotherapy or combination with insulin. The titration process follows adult guidelines to ensure gastric safety.
Meal Coordination: Always take the tablets during or after meals to protect the gastrointestinal tract.
Slow Titration: Increasing the dose gradually over several weeks significantly improves tolerance.
Gastrointestinal (Very Common): Nausea, vomiting, diarrhea, abdominal pain, and loss of appetite. These typically occur at the start of treatment.
Nervous System: Changes in taste (metallic sensation).
Metabolic: Rare cases of Lactic Acidosis. Long-term use may lead to decreased Vitamin B12 absorption (megaloblastic anemia).
Skin: Isolated reactions like erythema, itching, or urticaria.
Hepatobiliary: Rare cases of hepatitis or impaired liver function indicators.
Lactic Acidosis: This is a medical emergency. Avoid excess alcohol and be cautious during states of hypoxia.
Pregnancy: It is recommended to switch to insulin during pregnancy for more precise blood glucose control.
Lactation: Breastfeeding is not recommended as metformin passes into breast milk and safety data is limited.
Driving: Monotherapy is safe; however, combined therapy (with insulin or sulfonylureas) requires caution due to potential hypoglycemia.
No special temperature storage conditions are required.
Keep out of the reach of children.
Shelf Life: Refer to the expiration date on the original packaging.
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