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    3. Mezym Forte 10000, 10 capsules — Made in Germany — Free Delivery

    Mezym Forte 10000, 10 capsules — Made in Germany — Free Delivery


    Brand: Berlin-Chemie
    Product Code: Mezym Forte 10000
    Availability: In Stock
    $19.11
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    Pharmacological properties

    Pharmacodynamics. The active ingredient of the preparation Mezym Forte is a powder from the pancreas (pancreatin) of mammals, usually pigs, which, in addition to excretory pancreatic enzymes (lipase, alpha-amylase, trypsin and chymotrypsin), contains other enzymes. pancreatin also contains other related substances that do not have enzymatic activity.
    Pharmacokinetics. Suction. Powder from the pancreas is not absorbed in the gastrointestinal tract and is excreted in the feces. Most of it is degraded or denatured by digestive juices or bacteria.
    Bioavailability. The enteric coating of tablets, resistant to the action of gastric juice, protects acid-sensitive enzymes from inactivation when passing through the stomach. Only after reaching a neutral or slightly alkaline environment in the small intestine, enzymes are released after dissolution of the membrane. Due to the fact that the powder from the pancreas is not absorbed in the gastrointestinal tract, there is no information on its pharmacokinetics and bioavailability.
    The effectiveness of pancreatic powder is determined by the extent and rate of release of enzymes from the dosage form.

    Indications

    Violation of the exocrine function of the pancreas, accompanied by indigestion.

    Application

    Recommended dose per meal: 2-4 tablets of Mezym Forte 10,000 or 1–2 tablets of Mezym Forte 20,000 (corresponds to 20,000-40,000 units of e. F. Lipase).
    The dose of Mezym Forte is determined in accordance with the severity of the existing pancreatic insufficiency. Usually the recommended dose is a dose of 20,000–40,000 EF lipase per meal, but it may be higher.
    The goal of treatment with Mezym Forte is to achieve or maintain a normal body weight and normalize the frequency of bowel movements or the consistency of feces. Dose escalation should be carried out only under medical supervision and in order to reduce the severity of symptoms (for example, steatorrhea, stomach pain).
    Do not exceed the daily dose of enzymes, which is 15,000–20,000 IU of lipase per kilogram of body weight.
    Mezym Forte tablets should be swallowed whole, washed down with plenty of liquid, during meals, since the effectiveness of the Mezym Forte preparation may decrease when chewed, the enzymes contained in the preparation, when released in the oral cavity, can damage its mucous membrane.
    The duration of treatment depends on the course of the disease and is determined by the doctor.

    Contraindications

    Hypersensitivity to the active ingredient, pig meat (pork allergy) or any of the excipients of the preparation.
    Acute pancreatitis or chronic pancreatitis in the exacerbation phase (but episodic use is possible in the fading exacerbation phase with the expansion of the diet in the presence of pancreatic dysfunction). The preparation should not be used in patients with obstructive intestinal obstruction.

    Side effects

    To assess the incidence of side effects, the following classification is used: very often (≥1 / 10), often (≥1 / 100 and 1/10), infrequently (≥1 / 1000 and 1/100), rarely (≥1 / 10,000 and 1/1000), very rare (1/10 000), frequency unknown (cannot be estimated from available data).
    From the immune system. Very rare: immediate allergic reactions (skin rash, sneezing, lacrimation, bronchospasm, dyspnea), hypersensitivity reactions localized in the gastrointestinal tract.
    From the gastrointestinal tract. Very rare: diarrhea, abdominal discomfort, abdominal pain, nausea, vomiting. The formation of strictures in the ileocecal region and in the ascending colon has been described after administration of a preparation containing pancreatic powder in high doses.
    Suspected adverse reactions reported. The reporting of suspected adverse reactions following preparation registration is important. This allows you to continue monitoring the balance of benefits and risks of the preparation. Healthcare professionals should report any suspected adverse reactions.

    Special instructions

    In the event of unusual abdominal discomfort or changes in symptoms, it is recommended to undergo an examination to exclude intestinal damage as a preventive measure, especially when the patient is using a dose of 20,000 FU. lipase per 1 kg of body weight per day.
    The preparation contains active enzymes that can damage the mucous membrane of the oral cavity, up to the formation of ulcers, so the tablets should be swallowed whole without chewing.
    Mezym Forte should not be used in patients with rare hereditary forms of galactose intolerance, lactase deficiency or glucose and galactose malabsorption syndrome.
    During pregnancy and breastfeeding. There is no sufficient data on the use of the preparation Mezym Forte by pregnant women. There is insufficient data on the effects on pregnancy, embryo / fetal development, childbirth or postnatal development that have been obtained in animal experiments, so the potential risk to humans is unknown. In this regard, the preparation Mezym Forte should not be taken during pregnancy and lactation, unless its use is absolutely necessary.
    Children. The preparation Mezym Forte is used in children over the age of 3 years. The dose and duration of use is determined by the doctor.
    The ability to influence the reaction rate when driving or working with other mechanisms. The influence of Mezym Forteon the ability to drive vehicles or work with other mechanisms is absent or insignificant.

    Interactions

    When using preparations containing powder from the pancreas, it is possible to reduce the absorption of folic acid, which may necessitate its additional intake into the body. the hypoglycemic effect of acarbose and miglitol may decrease with the simultaneous use of the preparation Mezym Forte10,000 and Mezym Forte 20,000.

    Overdose

    The use of pancreatic enzymes in very high doses can be accompanied by hyperuricemia and hyperuricosuria. symptomatic treatment.

    Storage conditions

    At a temperature not exceeding 30 ° c.

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