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    3. Muskomed 4mg 20 capsules — Made in Turkey — Free Delivery

    Muskomed 4mg 20 capsules — Made in Turkey — Free Delivery


    Brand: World Medicine İlaç Sanayi ve Ticaret A.Ş.
    Product Code: Muskomed
    Availability: In Stock
    $21.88
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    Pharmacological properties

    Pharmacodynamics. Muskomed contains the active ingredient thiocolchicoside, a semi-synthetic muscle relaxant, which is obtained from the natural glycoside colchicoside. exhibits selective affinity for gamma and glycine receptors, which determines the effect of the preparation at various levels of the nervous system, both in spasms of a local nature and in spasms of central origin.
    Muskomed does not have a curariform effect, does not cause paralysis and does not affect the cardiovascular and respiratory systems.
    Pharmacokinetics. Absorption of thiocolchicoside after oral administration is rapid. Cmax in blood plasma is reached after 60 minutes. According to available data, in healthy volunteers after taking 8 mg of the preparation, the bioavailability was 24% compared with that with i / m use.
    Plasma protein binding is 13%. Thiocolquixoside binds to albumin.
    T½ is 2.5–5 hours. Approximately 20% of the dose is excreted in the urine as unchanged metabolites, 75–81% is excreted in the feces.

    Indications

    For additional short-term relief of painful muscle contractures.

    Application

    Take orally after meals. the maximum daily dose is 8-16 mg in 2 divided doses. the recommended course of treatment is 5-7 days.
    In preparation for physiotherapy procedures, the period of muscle relaxation is 1–2 hours after oral administration of the preparation.

    Contraindications

    Hypersensitivity to the components of the preparation , muscle hypotonia, mild paralysis.

    Side effects

    Rarely - skin rash, edema, allergic and pseudo-allergic reactions (allergic vasculitis), stomach pain, diarrhea. very rarely - hypotension, irritability and drowsiness.

    special instructions

    The preparation should be used with caution in case of impaired renal or liver function. the preparation  should be used with caution in patients with epilepsy or at risk of seizures.
    If an intolerance to some sugars has been established, you should consult your doctor before taking this medication, as this medication contains lactose monohydrate.
    Application during pregnancy or lactation. The preparation  is contraindicated during pregnancy and lactation.
    Children. The preparation  is contraindicated in children under the age of 16.
    The ability to influence the reaction rate when driving or operating other mechanisms. During the period of treatment, care must be taken when driving vehicles and engaging in other potentially unsafe activities that require increased concentration of attention and speed of psychomotor reactions.

    Interactions

    There are no data on preparation interactions. however, caution is advised when taking concomitantly with other muscle relaxants.
    With simultaneous use with preparations that depress the central nervous system, including alcohol, antihypertensive preparations, curariform preparations, it is possible to increase muscle relaxation and inhibition of the central nervous system, the development of hypotension.
    With simultaneous use with anticoagulants, the risk of bleeding increases.

    Overdose

    There is no evidence of overdose.
    Symptoms: possible increased adverse reactions.
    Treatment: symptomatic, supportive therapy.

    Storage conditions

    At a temperature not exceeding 25 ° c.

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