Polydexa ear drops 10,5ml — Made in France — Free Delivery

Pharmacodynamic parameters. The combination of active pharmaceutical ingredients of the Polydex preparation determines its anti-inflammatory and antimicrobial effects against a wide range of gram-positive and gram-negative pathogens of the external ear of an infectious and inflammatory nature.

Synthetic GCS dexamethasone penetrates the cell membrane and binds with a high affinity to specific cytoplasmic receptors of glucocorticoids, which ultimately leads to a modification of transcription and, consequently, protein synthesis to achieve inhibition of leukocyte infiltration at the site of inflammation, interference with the function of inflammatory mediators, suppression of humoral immune reactions and reduction of edema. The anti-inflammatory effect of dexamethasone involves the phospholipase A2 inhibiting proteins lipocortins, which control the biosynthesis of powerful inflammatory mediators such as prostaglandins and leukotrienes.

Neomycin is an aminoglycoside antibiotic isolated from cultures of Streptomyces fradiae. Its mechanism of action includes inhibition of the synthesis of proteins vital for the growth of microbial cells by binding to the 30S subunit of the bacterial ribosome. Neomycin can also inhibit bacterial DNA polymerase.

Neomycin is active against B. catarrhalis and Haemophilus influenzae, acinetobacteria, corynebacteria, causative agents of listeriosis, methicillin-susceptible staphylococcus, bacteria of the genus Citrobacter, enterobacter, Campylobacter, Escherichia coli, Klebsiella, Morganinella and Proteusia, Provigersia ...

Neomycin-resistant enterococci, streptococci, methicillin-resistant staphylococci, chlamydia, mycoplasma, rickettsia, P. stuartii, Pseudomonas aeruginosa, A. denitrificans, burkholderia, N. asteroides, flavobacteria, resistant microorganisms.

Polymyxin B, a lipopeptide antibiotic isolated from Bacillus polymyxa, is bactericidal against gram-negative bacteria: the α- and γ-diaminobutyric acids of the positively charged polymyxin B form electrostatic interactions with the phosphate groups of negatively charged lipid A on the outer membrane of the gram-negative bacteria. Calcium and magnesium ions are displaced from the phosphates of membrane lipids, destabilizing the lipopolysaccharide, which increases the permeability of the membrane and, as a result, leads to cell destruction. In addition, polymyxin B inhibits type II NADH-quinone oxidoreductase required for cellular respiration on the inner bacterial membrane, and can also bind and neutralize lipopolysaccharide released during bacterial lysis, preventing reactions to endotoxin.

Acinetobacteria, aeromonads, Alcaligenes spp., Microorganisms of the genera Citrobacter, Enterobacter, Escherichia coli, Klebsiella, Moraxella, Pseudomonas aeruginosa, Salmonella, Shigella, S. maltophilia are sensitive to polymyxin B.

Show resistance to polymyxin B of Brucella, Burkholderia (B. cepacia, B. pseudomallei), Mycobacterium, B. catarrhalis, Campylobacter, Legionella, Morganella, Proteus, Neisseria, Serracias, Providence, C. meningosepticum, Cholerae Vibrio and Shavarovidia rod-shaped spore-forming bacteria.

Pharmacokinetic parameters. In the case of an intact tympanic membrane, there is no absorption into the systemic circulation.

Topical therapy for external otitis media of bacterial etiology in the absence of damage to the tympanic membrane (including eczema of the external auditory canal of an infectious nature).

Locally (instillation into the external auditory canal) 2 times a day - in the morning and in the evening.

Adults 1-5 drops, children 1-2 drops (depending on age).

The duration of the course of therapy (on average 1 week) is individual and is determined by the severity of the pathology and its nature.

Before use, warm the bottle in your hands to body temperature. Tilt your head (and keep in this position for another 5 minutes after instillation); drip the preparationinto the external auditory canal, not under pressure, then slightly pull the earlobe (repeat several times).

At the end of the course of therapy, dispose of the vial, do not reuse.

Hypersensitivity to active pharmaceutical ingredients or other components of the preparation;

the presence (or assumption of the presence) of a violation of the integrity of the tympanic membrane;

infectious process of the external auditory canal of viral etiology (including chickenpox and herpes simplex).

Allergic reactions and sensitization to antibiotics as part of the Polydex preparation; contact dermatitis, local allergic reaction and skin irritation; with perforation of the tympanic membrane - vestibular or cochlear ototoxic effects; the development of microorganisms and mycoses insensitive to antibiotics in the composition of the Polydex preparation.

Before starting therapy, an examination of the tympanic membrane is required.