Preductal OD capsules are indicated for adults for the symptomatic treatment of stable angina pectoris with insufficient efficacy or intolerance to first-line antianginal preparations.
Active substance: trimetazidine;
Preductal® OD 40 mg
1 sustained-release solid capsule contains 40 mg of trimetazidine dihydrochloride;
Excipients: spherical sugar *, hypromellose, ethyl cellulose, acetyltributyl citrate, talc, magnesium stearate;
Capsule shell: titanium dioxide (E 171), gelatin; ink: shellac (E 904), propylene glycol (E 1520), concentrated ammonia solution (E 527), potassium hydroxide (E 525), titanium dioxide (E 171), black iron oxide (E172)
Preductal® OD 80 mg
1 sustained-release solid capsule contains 80 mg of trimetazidine dihydrochloride;
Excipients: spherical sugar *, hypromellose, ethyl cellulose, acetyltributyl citrate, talc, magnesium stearate;
Capsule shell: titanium dioxide (E 171), gelatin, iron oxide red (E172) ink: shellac glaze-45% (20% esterified) in ethanol, titanium dioxide (E 171), simethicone, propylene glycol (E 1520), ammonium hydroxide 28% (E 527).
* Spherical sugar (710-850 microns) contains sucrose and corn starch
Hypersensitivity to the active substance or to any excipient.
Parkinson's disease, parkinsonism symptoms, tremors, restless legs syndrome and other movement disorders related to the above.
Severe renal impairment (creatinine clearance <30 ml / min).
For oral administration.
The recommended dose is 1 capsule of trimetazidine 80 mg 1 time per day in the morning with breakfast. Capsules should be taken without opening and with water.
After 3 months of treatment, it is necessary to evaluate the results of treatment and, if there is no response to treatment, trimetazidine should be canceled.
Pregnant
Application is not recommended.
Drivers
Carefully.
The amount of data on trimetazidine overdose is limited. Treatment is symptomatic.
From the gastrointestinal tract: pain in the abdominal region of the abdomen, diarrhea, dyspepsia, nausea and vomiting.
Skin and subcutaneous tissue disorders: rash, itching, urticaria.
General disorders: asthenia.
Interaction with other preparations has not been identified. In particular, trimetazidine can be prescribed in combination with heparin, calciparin, vitamin K antagonists, oral lipid-lowering preparations, aspirin, β-blockers, calcium antagonists, digitalis preparations (trimetazidine does not affect the level of digoxin in the blood plasma).
Does not require special storage conditions. Keep out of the reach of children.
Expiration date - 30 months.
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