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    3. Relief rectal ointment 28.4g — Made in Germany — Free Delivery

    Relief rectal ointment 28.4g — Made in Germany — Free Delivery


    Brand: BAYER
    Product Code: Relief
    Availability: In Stock
    $21.88
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    Pharmacological properties

    Pharmacodynamics
    Phenylephrine hydrochloride has a local vasoconstrictor effect. This normalizes the relationship between blood flow to hemorrhoids and blood outflow from them, and also helps to reduce exudation, swelling, itching, serous discharge in hemorrhoids and other diseases of the anorectal region.
    Pharmacokinetics
    A preparation for topical use. Phenylephrine, which is part of it, is inactivated by tissue MAO, inactive metabolites are excreted in mucus or in small amounts by the kidneys.

    Indications

    Symptomatic treatment of itching, burning and discomfort that accompany hemorrhoids and other diseases of the anorectal zone, as well as with erosions, cracks, microtrauma in the anus.

    Contraindications

    Hypersensitivity to the components of the preparation, a significant increase in blood pressure, tachysystolic heart rhythm disturbances, decompensated heart failure, cardiac conduction disorders, severe renal and hepatic failure, thyrotoxicosis, acute pancreatitis, simultaneous use with MAO inhibitors (MAO) or within 15 days after discontinuation treatment with MAO inhibitors, thromboembolic disease, granulocytopenia.
    Method of administration and dosage
    For adults and children over 12 years of age, use the preparation after hygiene procedures. Remove the protective cap from the applicator. Attach the applicator to the tube and squeeze out enough ointment to lubricate the applicator. Carefully apply the ointment through the applicator to the affected areas outside or inside the anus in an amount sufficient to treat the affected areas, up to 4 times a day, preferably in the evening, in the morning or after each bowel movement. Apply until the symptoms of the disease disappear. Rinse the applicator thoroughly after each use and place it in the protective cap. Do not use if protective coating is missing or damaged.

    Structure

    Active ingredient: phenylephrine hydrochloride.
    1 g of ointment contains phenylephrine hydrochloride 2.5 mg.
    Excipients: mineral oil, tocopherol, thyme oil, corn oil, glycerin, white soft paraffin, methyl parahydroxybenzoate (E 218), propyl parahydroxybenzoate (E 216), lanolin, benzoic acid (E 210), lanolin alcohol, wax, purified water white.

    Overdose

    In medical practice, it is not described, there are no data on systemic, including toxic, reactions of the body in response to rectal administration of Relief®. However, in case of an overdose, an increase in the manifestations of adverse reactions is possible, especially with prolonged use. Arterial hypertension, pain and discomfort in the heart, palpitations, shortness of breath, noncardiogenic pulmonary edema, agitation, convulsions, sleep disturbances, anxiety, paranoia, irritability, psychosis with hallucinations, weakness, anorexia, nausea, vomiting, oliguria, urinary retention, redness of the face, feeling of coldness in the extremities, paresthesia, hypersensitivity, hyperglycemia, hypokalemia, reduced blood flow to vital organs, which can lead to a deterioration in the blood supply to the kidneys, metabolic acidosis, an increase in the load on the heart due to an increase in the total resistance of peripheral vessels. Treatment is symptomatic.

    Adverse Reactions

    This preparation is usually well tolerated, but in rare cases, phenylephrine hydrochloride-related adverse reactions may occur.
    From the side of the cardiovascular system: reflex bradycardia, arrhythmia, possible cardiac arrhythmias, increased blood pressure.
    From the immune system: allergic reactions, including cross-reactions in case of allergy to other sympathomimetics, which may manifest as rash, itching, angioedema.
    From the endocrine system: an increase in symptoms of hyperthyroidism.
    Skin and subcutaneous tissue disorders: contact dermatitis.
    From the nervous system: dizziness, nervousness, headache, tremors, insomnia, fear, feeling of blood rush to the face.
    At the site of application, possible irritation, hyperemia, rash, itching, edema, moderate pain / burning with injury or bleeding from the anus.
    Methylparaben and propyl parahydroxybenzoate can cause allergic reactions (possibly delayed) and, in some cases, bronchospasm. Lanolin can cause local skin reactions (eg contact dermatitis). Benzoic acid is mildly irritating to skin, eyes and mucous membranes.

    Application features

    Use during pregnancy or lactation
    Since the safety of using the preparation  Relief ® (phenylephrine) during pregnancy has not been studied, the use of the preparation  is possible if, in the opinion of the doctor, the benefit to the mother outweighs the potential risk to the fetus / child.
    Pregnant women should consult a doctor before using the preparation.
    Since it is not known whether topical application of the preparation Relief ® (phenylephrine) can lead to sufficient systemic absorption to cause measurable excretion into breast milk, the physician must determine the importance of the preparation to the mother: whether it is necessary to stop breastfeeding or discontinue the preparation. The study of the effect of the preparation on fertility has not been conducted.
    Children
    The efficacy and safety of the preparation Relief® for children under 12 years of age have not been studied. No data available.
    The ability to influence the reaction rate when driving or driving other mechanisms
    There was no effect on the ability to drive vehicles or other mechanisms.
    Interaction with other medicinal products and other types of interactions
    It should not be used in conjunction with other vasoconstrictors (for any route of administration of the latter), as well as with antihypertensive preparations (β-blockers), since phenylephrine can cause severe hypertension in some individuals due to stimulation of α-adrenergic receptors.
    Atropine sulfate blocks phenylephrine-induced reflex bradycardia and increases the vasopressor response to phenylephrine. Simultaneous administration of phenylephrine with ß-blockers can lead to arterial hypertension and excessive bradycardia with possible heart block. It should be used with caution with thyroid hormones, preparations that affect cardiac conduction (cardiac glycosides, antiarrhythmic preparations).
    With simultaneous use with preparations that predetermine potassium excretion, for example, with some diuretics such as furosemide, hypokalemia may increase and arterial sensitivity to vasopressor preparations such as phenylephrine may decrease.
    The simultaneous administration of phenylephrine and other sympathomimetics can lead to additional stimulation of the central nervous system to extremely high levels, accompanied by nervousness, irritability, and insomnia. Seizures are also likely.
    If you are using MAO inhibitors, you should consult your doctor before using phenylephrine in the anorectal area. MAO inhibitors, used before starting treatment with phenylephrine, potentiate the cardiac and pressor effects of the latter, since the metabolism of phenylephrine decreases.
    With local application of the preparation Relief®, rectal ointment, in the anus, an auxiliary substance white soft paraffin can reduce the strength and safety of latex condoms used simultaneously with the preparation.

    Storage conditions

    Keep out of the reach of children at a temperature not exceeding 25 ° C.
    Shelf life is 2 years.
    The opening of the tube and the beginning of the use of the preparation does not affect the shelf life, provided that it is tightly closed with a cap each time after use. Do not use after the expiration date printed on the package.

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