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    3. Relief rectal suppositories 12 pcs — Made in Germany — Free Delivery

    Relief rectal suppositories 12 pcs — Made in Germany — Free Delivery


    Brand: BAYER
    Product Code: Relief
    Availability: In Stock
    $25.34
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    Pharmacological properties

    Pharmacodynamics. Phenylephrine hydrochloride is an adrenergic agonist, the use of which leads to a local vasoconstrictor effect. this normalizes the ratio between blood flow to hemorrhoids and blood outflow from them, and also helps to reduce exudation, swelling, itching, serous discharge in hemorrhoids and other diseases of the anorectal region.
    Pharmacokinetics. Relief® is a topical preparation. Phenylephrine, which is part of it, is inactivated by tissue MAO, inactive metabolites are excreted in mucus or in small amounts by the kidneys.

    Indications

    Relief®, ointment. symptomatic treatment of itching, burning and discomfort that accompany hemorrhoids and other diseases of the anorectal zone, as well as with erosions, cracks, microtrauma in the anus.
    Relief®, suppositories. External and internal hemorrhoids, cracks in the anus, erosion and microtrauma of the anus, anal itching.

    Application

    In adults and children over the age of 12, the preparation should be used after hygiene procedures.
    Relief®, ointment. Remove the protective cap from the applicator. Attach the applicator to the tube and squeeze out enough ointment to lubricate the applicator. Carefully apply the ointment through the applicator to the affected areas outside or inside the anus in an amount sufficient to treat the affected areas, up to 4 times a day, preferably in the evening, in the morning or after each bowel movement. Apply until the symptoms of the disease disappear. Rinse the applicator thoroughly after each use and place it in the protective cap. Do not use if protective coating is missing or damaged.
    Relief®, suppositories. Pre-wash the skin around the anus with warm water, clean the affected area with a moistened soft cloth, then gently dry with toilet paper or a soft cloth, removing excess moisture.
    Before the introduction of the suppository, it is necessary to remove the plastic protective shell from it. Insert the suppository into the anus.
    Enter 1 suppository up to 4 times a day, especially at night, in the morning and after each bowel movement. The duration of treatment is 7-14 days. Regular use of the preparation allows for a stable therapeutic effect, relieves the symptoms of hemorrhoids. Do not use if protective coating is missing or damaged.
    Children. The efficacy and safety of using Relief® in children under the age of 12 have not been studied. No data available.

    Contraindications

    Hypersensitivity to any component of the preparation, a significant increase in blood pressure, tachysystolic heart rhythm disturbances, decompensated heart failure, cardiac conduction disorders, severe renal and hepatic failure, thyrotoxicosis, acute pancreatitis, simultaneous use with MAO inhibitors or within 15 days after stopping treatment MAO inhibitors, thromboembolic disease, granulocytopenia.

    Side effects

    The preparation is usually well tolerated, but in rare cases, adverse reactions due to phenylephrine hydrochloride are possible.
    From the side of the cardiovascular system: reflex bradycardia, arrhythmia, heart rhythm disturbances, increased blood pressure are possible.
    From the endocrine system: an increase in symptoms of hyperthyroidism.
    On the part of the immune system: allergic reactions, including cross-reactions in case of allergy to other sympathomimetics, which can manifest itself in the form of rashes, itching, angioedema.
    Skin and subcutaneous tissue disorders: contact dermatitis.
    From the nervous system: dizziness, nervousness, headache, tremors, insomnia, fear, feeling of blood rush to the face.
    At the site of application, irritation, hyperemia, rash, itching, edema, moderate pain / burning with injury or bleeding from the anus are possible.
    Methyl parahydroxybenzoate and propyl parahydroxybenzoate can cause allergic reactions (possibly delayed) and, in some cases, bronchospasm. Lanolin can cause local skin reactions (eg contact dermatitis). For Relief, ointment: benzoic acid is mildly irritating to the skin, eyes and mucous membranes.

    Special instructions

    In case of significant bloody discharge from the anus or in the presence of symptoms of the disease for more than 7 days of treatment, or in case of deterioration of the condition, it is necessary to additionally consult with a proctologist.
    The preparation should be used with caution in patients with hypertension, cardiovascular or cerebrovascular diseases, increased thyroid function (phenylephrine can cause adverse cardiovascular effects, especially when used in high doses or in sensitive individuals), angle-closure glaucoma.
    Patients with diabetes mellitus require caution when using this preparation: phenylephrine can increase blood glucose levels. These effects are usually temporary and minor and may increase when the recommended doses are exceeded. Blood glucose levels should be closely monitored.
    Persons with impaired urination due to hypertrophy or the presence of prostatic neoplasms: phenylephrine may impair urination in patients with prostatic hypertrophy due to spasm of the smooth muscles of the bladder neck resulting from stimulation of α1-adrenergic receptors.
    With hepatitis, urinary disorders, the use of the preparation is permissible taking into account the benefit / risk ratio, which is determined by the doctor.
    If an appropriate level of systemic absorption is achieved, the likelihood of interaction of phenylephrine applied topically in the anorectal region with MAO inhibitors should be taken into account, which leads to a potentiation of the hypertensive effect.
    Consideration should be given to the likelihood that phenylephrine, applied topically to the anorectal region, can cause severe hypertension due to stimulation of α-adrenergic receptors in some individuals while using this preparation with antihypertensive preparations.
    To minimize systemic effects, the recommended dose should not be exceeded unless otherwise advised by a physician.
    Do not use the preparation in the form of suppositories if the protective plastic sheath is damaged or missing.
    Use during pregnancy and lactation. Since the safety of using the preparation Relief® (phenylephrine) during pregnancy has not been studied, its use is possible if, in the opinion of the doctor, the benefit to the mother outweighs the potential risk to the fetus / child.
    Pregnant women should consult a doctor before using the preparation.
    Since it is not known whether topical application of the preparation Relif® (phenylephrine) can lead to sufficient systemic absorption to cause a measurable release of phenylephrine into breast milk, the physician must determine the importance of the preparation to the mother: whether it is necessary to stop breastfeeding or to discontinue the preparation.
    Studies of the effect of the preparation on fertility have not been carried out.
    The ability to influence the reaction rate when driving or operating other mechanisms. There was no effect on the ability to drive vehicles or operate other mechanisms.

    Interactions

    The preparationshould not be used concurrently with other vasoconstrictor agents (for any route of administration of the latter), as well as with antihypertensive preparations (β-adrenergic receptor blockers), since phenylephrine can cause severe arterial hypertension in some individuals due to the stimulation of α-adrenergic receptors.
    Atropine sulfate blocks phenylephrine-induced reflex bradycardia and increases the vasopressor response to phenylephrine. Concomitant use of phenylephrine with β-adrenergic receptor blockers can lead to hypertension and excessive bradycardia with possible heart block. It should be used with caution with thyroid hormones, preparations that affect cardiac conduction (cardiac glycosides, antiarrhythmic preparations).
    With simultaneous use with preparations that promote the excretion of potassium, for example with some diuretics such as furosemide, hypokalemia may increase and decrease arterial sensitivity to vasopressor preparations such as phenylephrine.
    The simultaneous use of phenylephrine and other sympathomimetics can lead to additional stimulation of the central nervous system to an extremely high level, which is accompanied by nervousness, irritability, and insomnia. Seizures are also likely.
    If you are using MAO inhibitors, consult your doctor before using phenylephrine in the anorectal area. MAO inhibitors, used before starting treatment with phenylephrine, potentiate the cardiac and pressor effects of the latter, since the metabolism of phenylephrine decreases.
    With local application of the preparation Relief®, rectal ointment, in the anus, an auxiliary substance white soft paraffin can reduce the strength and safety of latex condoms used simultaneously with the preparation.

    Overdose

    It is not described in medical practice, there are no data on systemic, including toxic, reactions of the body in response to rectal administration of the preparation Relief®. however, in case of an overdose, an increase in the manifestations of adverse reactions is possible, especially with prolonged use. ag, pain and discomfort in the region of the heart, palpitations, shortness of breath, noncardiogenic pulmonary edema, agitation, convulsions, sleep disturbance, anxiety, paranoia, irritability, psychosis with hallucinations, weakness, anorexia, nausea, vomiting, oliguria, urinary retention, redness of the face, a feeling of coldness in the extremities, paresthesias, hypersensitivity, hyperglycemia, hypokalemia, reduced blood flow to vital organs, which can lead to a deterioration in the blood supply to the kidneys, metabolic acidosis, and an increase in the load on the heart due to an increase in the volume of blood pressure. symptomatic treatment.

    Storage conditions

    At a temperature not exceeding 25 ° c.
    Opening the tube of the preparation Relief®, ointment, and the beginning of the use of the preparation do not affect the shelf life, provided that it is tightly closed with a cap each time after use.
    It is forbidden to store Relief®, suppositories, with an open or missing protective plastic shell.

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