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    3. Sevikar 40mg/10mg 28 tablets — Made in Germany — Free Delivery

    Sevikar 40mg/10mg 28 tablets — Made in Germany — Free Delivery


    Brand: Daiichi Sankyo Europe GmbH
    Product Code: Sevikar
    Availability: In Stock
    $42.45
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    Product description 

    Sevikar tablets are used for the following indications:
    • Treatment of essential hypertension.
    • Sevicar is indicated in patients in whom olmesartan medoxomil or amlodipine monotherapy does not provide adequate blood pressure control.

    Compound

    Active ingredient: olmesartan medoxomil; amlodipine besilate.
    1 coated tablet contains olmesartan medoxomil 40 mg, amlodipine besylate 13.888 mg, equivalent to amlodipine 10 mg.
    Excipients: corn starch, silicon microcrystalline cellulose (contains 98% microcrystalline cellulose (Ph. Eur.) And 2% anhydrous colloidal silicon dioxide (Ph. Eur.)), Croscarmellose sodium, magnesium stearate (vegetable origin).
    Plivka shell contains Opadry II 85F18422 white or Opadry II 85F22093 yellow, or Opadry II 85F25467 red (polyvinyl alcohol, titanium dioxide (E 171), polyethylene glycol, talc, iron oxide yellow (E172), iron oxide red (E172)).

    Contraindications

    Hypersensitivity to the active ingredients, dihydropyridine derivatives or any of the excipients.
    Pregnancy and pregnancy planning.
    Severe liver failure and obstruction of the biliary tract.
    The simultaneous use of the preparation Sevikar and preparations containing aliskiren is contraindicated in patients with diabetes mellitus or impaired renal function (GFR <60 ml / min / 1.73 m2).
    Due to the presence of amlodipine, Sevikar is also contraindicated in patients who:
    • severe arterial hypotension
    • shock (including cardiogenic shock);
    • violation of the outflow of blood from the left ventricle (for example, with severe aortic stenosis);
    • hemodynamically unstable heart failure after acute myocardial infarction.

    Mode of application

    The recommended dose of Sevikar is 1 tablet per day.
    Sevicar 20/5 can be administered to patients with insufficient body response to monotherapy with olmesartan medoxomil at a dose of 20 mg or amlodipine at a dose of 5 mg.
    Sevikar 40/5 can be administered to patients with insufficient body response to Sevikar 20/5.
    Sevikar 40/10 can be administered to patients with insufficient body response to Sevikar 40/5.
    Prior to prescribing a combination preparationwith fixed doses of active ingredients, it is recommended to gradually select the doses of these components as monopreparations. If necessary, a direct replacement of monopreparations with a combined preparation is possible.
    For convenience, patients who receive olmesartan medoxomil and amlodipine as separate tablets can be switched to Sevicar tablets containing these components in similar doses.
    Sevikar can be taken with or without food.

    Peculiarities

    pregnant
    Contraindicated.
    Children
    No data available.
    Drivers
    Sevikar is able to slightly or moderately affect the ability to drive vehicles and operate other mechanisms.

    Overdose

    Cases of overdose of Sevikar have not been recorded. The most likely effects of an overdose of olmesartan medoxomil are hypotension and tachycardia, and bradycardia may be observed with parasympathetic stimulation (vagus nerve). An overdose of amlodipine can lead to excessive expansion of peripheral vessels, accompanied by a pronounced decrease in blood pressure, and possibly reflex tachycardia. There are reports of prolonged severe generalized hypotension, up to fatal shock.

    Side effects

    The most common adverse reactions that occurred with the use of the preparation Sevikar were peripheral edema (11.3%), headache (5.3%) and dizziness (4.5%).

    Interaction

    The hypotensive effect of the preparation Sevikar may be enhanced with the simultaneous use of other antihypertensive preparations (eg alpha-blockers, diuretics).

    Storage conditions

    Does not require special storage conditions.
    Keep out of the reach of children.
    Shelf life: 5 years.

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