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    3. Tisercin solution for injections 25 mg/ml, 1ml x 10 ampoules — Made in Hungary — Free Delivery

    Tisercin solution for injections 25 mg/ml, 1ml x 10 ampoules — Made in Hungary — Free Delivery


    Brand: EGIS
    Product Code: Tisercin
    Availability: In Stock
    $20.72
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    Pharmacological properties

    Tisercin is a neuroleptic of the phenothiazine series, which has an antipsychotic, analgesic and moderate antiemetic effect. stops psychomotor agitation, has a sedative effect, exhibits antidepressant, adrenoblocking, moderate anticholinergic and antihistamine activity. causes hypotension.
    The maximum concentration in blood plasma is reached 30-90 minutes after i / m administration. The metabolite formed as a result of demethylation has pharmacological activity, others are inactive. The half-life is 15–78 hours. It is eliminated in urine and feces.

    Indications

    Psychomotor agitation of various etiologies: manic stage of manic-depressive psychosis, depressive-paranoid form of schizophrenia, catatonic agitation, reactive depression, alcoholic psychosis and other psychotonic states accompanied by symptoms of anxiety, fear;
    neurotic disorders with increased arousal, sleep disturbance;
    diseases accompanied by pain syndrome: trigeminal neuralgia, herpes zoster, etc.;
    itching dermatoses (as a means of additional therapy);
    epilepsy, oligophrenia (as part of combination therapy);
    to potentiate the action of analgesics, preparations for anesthesia.

    Application

    In psychotic conditions, the daily dose is 25-50 mg (1-2 tablets), if necessary, the dose can be increased to 150-250 mg / day (6-10 tablets per day). Do not take 10 tablets per day.
    To reduce feelings of anxiety, the initial daily dose is 12.5–25 mg (1/2–1 tablet) per day. If necessary, this dose can be increased to 75-100 mg / day (3-4 tablets per day). After the condition improves, the dose can be reduced and a maintenance dose selected.
    Parenteral administration of the preparation is indicated in cases where oral administration is not possible. The daily dose is usually 75-100 mg 1-2 times a day (3-4 ml of the preparation) under the control of blood pressure and heart rate. Injections must be done deep in / m. For intravenous use, the solution should be diluted and administered only as a drip infusion (50–100 mg of the preparation in 250 ml of isotonic sodium chloride solution or glucose solution).

    Contraindications

    Tablets and solution of tisercin should not be used:
    • if you are allergic to phenothiazine or any of the ingredients that make up the preparation;
    • during pregnancy (or its planning) or breastfeeding;
    • with severe liver disease, changes in blood counts, circulatory failure;
    • in case of a sudden decrease in blood pressure;
    • during treatment with an antidepressant belonging to MAO inhibitors;
    • in the treatment of preparations to lower blood pressure (especially guanethidine and an ACE inhibitor).
    The preparation should not be administered to children and persons who are unconscious, intoxicated or under the influence of preparations.

    Side effects

    The most common side effect is postural hypotension. in this case, loss of consciousness, dizziness, drowsiness or increased fatigue may occur. in addition, side effects such as dry mouth, tachycardia, constipation and/or difficulty urinating may be noted. noted cases of impotence, frigidity, cessation of menstrual bleeding.
    In some cases, the composition of the blood changed and neurological symptoms occurred (extrapyramidal disorders are possible with a predominance of the akinetic-hypotonic syndrome, for example, inability to stand still, tremor). Also, allergic reactions and photosensitivity reactions can sometimes develop.

    special instructions

    If the patient has already taken MAO inhibitors, then before starting treatment with Tisercin, it is necessary to take a break of at least 14 days, during which no preparation should be taken.
    Before and during treatment, you should regularly monitor the composition of peripheral blood and the functional state of the liver, kidneys, heart, and in elderly patients - blood pressure.
    During treatment, the use of alcoholic beverages is prohibited.
    In debilitated and elderly patients, it is recommended to reduce the dose.
    At the beginning of treatment, patients taking the preparation should refrain from potentially hazardous activities that require increased attention and quick response. In the future, these restrictions depend on the individual response to the preparation.

    Interactions

    MAO inhibitors increase the risk of extrapyramidal disorders during treatment with tisercin due to a decrease in preparation inactivation in the liver.
    The simultaneous appointment of Tisercin and preparations that depress the central nervous system leads to an increase in the central depressive effect. Tisercin blocks dopaminergic receptors and therefore has an antagonistic effect when used simultaneously with levodopa. Under the influence of Tisercin, the antiparkinsonian effect of levodopa is sharply reduced.
    With the simultaneous use of Tisercin and antihypertensive preparations, the risk of orthostatic hypotension increases.

    Overdose

    Symptoms: convulsive syndrome, coma.
    Treatment: resuscitation and symptomatic therapy.

    Storage conditions

    In a place protected from light at a temperature of 15-25 ° C.

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