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    3. Valsacor H 160mg / 12.5mg, 84 tablets — Made in Slovenia— Free Delivery

    Valsacor H 160mg / 12.5mg, 84 tablets — Made in Slovenia— Free Delivery


    Brand: KRKA
    Product Code: Valsacor H 160mg / 12.5mg
    Availability: In Stock
    $35.74
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    Pharmachologic effect

    Valsacor N is a combined antihypertensive preparation.
    Valsartan is a selective angiotensin II receptor antagonist, non-proteinaceous in nature.
    Hydrochlorothiazide is a thiazide diuretic, the diuretic effect of which is associated with impaired reabsorption of sodium, chlorine, potassium, magnesium, water in the distal nephron; delays the excretion of calcium ions, uric acid. Has a hypotensive effect, which is due to the expansion of arterioles. Virtually no effect on normal blood pressure.
    Indications
    Arterial hypertension (in patients for whom combination therapy is indicated).

    Composition

    Film-coated tablets:
    1 tablet contains valsartan 80, 160 or 320 mg and hydrochlorothiazide 12.5 mg
    excipients: MCC; lactose monohydrate, magnesium stearate, croscarmellose sodium, povidone, colloidal anhydrous silicon dioxide;

    Contraindications

    • Hypersensitivity to valsartan, hydrochlorothiazide, sulfonamide derivatives and to other components of the preparation;
    • severe liver dysfunction;
    • biliary cirrhosis of the liver and obstruction of the biliary tract (cholestasis);
    • anuria, severe renal dysfunction (CC less than 3 ml / min (.5 ml / sec));
    • hemodialysis;
    • hypokalemia, hyponatremia, hypercalcemia or hyperuricemia with clinical manifestations refractory to adequate therapy;
    • galactose intolerance, lapp lactase deficiency or glucose / galactose malabsorption syndrome;
    • age under 18;
    • pregnancy and lactation;
    The preparation should be used with caution while taking potassium preparations, potassium-sparing diuretics, potassium-containing substitutes for table salt and other preparationsthat can increase the level of potassium in the blood (for example, heparin), chronic heart failure of functional class IV according to the NYHA classification, renal failure (CC more than 3 ml / min (.5 ml / sec)), moderate liver dysfunction, bilateral or unilateral renal artery stenosis or stenosis of an artery of a single kidney, condition after kidney transplantation, conditions accompanied by a decrease in BCC and / or sodium ions (incl. diarrhea, vomiting), primary hyperaldosteronism, stenosis of the aortic and mitral valves, hypertrophic obstructive cardiomyopathy (GOKMP), systemic lupus erythematosus, hypersensitivity to other angiotensin II receptor antagonists, allergic reactions and bronchial asthma.

    Method of administration and dosage

    Valsakor N is taken orally, regardless of food intake, once a day.
    The preparation can be combined with other antihypertensive preparations.
    If the hypotensive effect is insufficient, it is possible to increase the dose of the preparation to the maximum daily dose - 2 tablets Valsakor N8 or 1 tablet Valsakor ND16 1 time per day.
    The maximum antihypertensive effect of Valsacor N develops within 2-4 weeks. If necessary (the level of diastolic blood pressure is higher than 1 mm Hg against the background of monotherapy with valsartan), to achieve a more pronounced effect, it is possible to increase (not earlier than 4-8 weeks) the dose of the preparation to 16/25 mg (it is possible to use the preparation Valsacor ND16) 1 once a day.
    The maximum recommended daily dose of valsartan in patients with mild or moderate liver dysfunction of non-biliary origin is 8 mg (1 tablet per day Valsacor N8).

    Side effects

    From the side of the central nervous system and peripheral nervous system: often - general weakness; sometimes - increased fatigue, asthenia, dizziness, incl. postural, vertigo, insomnia; rarely - headache, depression, paresthesia, neuralgia; very rarely - fainting (when used after myocardial infarction).
    From the respiratory system: often - nasopharyngitis; sometimes - upper respiratory tract infections, rhinitis, sinusitis, cough; very rarely - respiratory distress syndrome with pneumonitis and pulmonary edema.
    From the side of the cardiovascular system: sometimes - chest pain; often - a marked decrease in blood pressure and orthostatic hypotension; very rarely - arrhythmias; potentially possible - peripheral edema.
    From the digestive system: often - diarrhea; sometimes - nausea, indigestion, abdominal pain; rarely - gastroenteritis, decreased appetite, constipation, hyperbilirubinemia, increased activity of hepatic transaminases; very rarely - pancreatitis, intrahepatic cholestasis, jaundice.
    On the part of the skin: rarely - skin rash, photosensitivity; very rarely - alopecia.
    From the musculoskeletal system: sometimes - pain in the back, limbs, sprains and ruptures of ligaments and muscles or muscle tendons, arthritis, arthralgia; rarely - myalgia, muscle weakness, muscle cramps.
    From the genitourinary system: sometimes - decreased libido, impotence (less than 1%), urinary tract infections, viral infections, increased frequency of urination; rarely - hypercreatininemia, increased concentration of serum urea nitrogen; very rarely - impaired renal function.
    From the senses: sometimes - visual impairment; rarely - tinnitus, conjunctivitis.
    Allergic reactions: very rarely - angioedema, urticaria, skin rash, itching, hypersensitivity reactions, including serum sickness and necrotizing vasculitis, toxic epidermal necrolysis (Lyell's syndrome), lupus-like reactions, exacerbation of the course of SLE.
    From the hematopoietic system: rarely - anemia, incl. hemolytic, leukopenia, agranulocytosis, bone marrow intoxication, decreased hemoglobin and hematocrit concentration, neutropenia, thrombocytopenia (sometimes with purpura).
    On the part of laboratory parameters: often - hyperkalemia, hypokalemia, hyponatremia, hypomagnesemia, hypercalcemia.
    Others: rarely - increased sweating; very rarely - nosebleeds.

    Storage conditions

    In a dry, dark place at a temperature not exceeding 3 ° C.
    Shelf life is 2 years.

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