Pharmacodynamics. Denotivir is an active ingredient of an antiviral preparation for external use. it suppresses the replication of viruses, including herpes simplex, reduces the duration of the disease, and, when used in the prodromal period, can prevent the development of this disease (does not prevent the recurrence of herpes simplex).
Pharmacokinetics. In the form of a cream, denotivir does not penetrate into the deep layers of the skin, therefore it is impossible to determine its concentration in blood plasma.
Herpes on the lips and face caused by the herpes simplex virus.
Vratizoline is only prescribed for topical use on the skin. hands should be washed before and after applying the cream to prevent transmission of infection to other areas of the skin. herpes treatment should be started as soon as possible after the first symptoms, such as itching and burning, appear. it is necessary to apply a small amount of cream (the size of a pea) 2-3 times a day on herpetic ulcers. treatment usually lasts 5 days. in patients infected with the virus, relapses of the disease may occur. in this case, it is necessary to immediately apply vratisolin cream to prevent the formation of vesicles.
Hypersensitivity to the active substance or other components of the preparation.
Signs of hypersensitivity, local reactions such as skin irritation at the site of application, contact dermatitis.
Vratizoline is prescribed only for the treatment of herpes, which can appear anywhere on the lips and face. Do not apply to mucous membranes such as lips and eyes (outer lips and eyes). do not use the preparation for the treatment of genital herpes. for the treatment of especially complex and often manifested forms of herpes, it is necessary to consult a doctor. patients who are infected with the herpes simplex virus should be warned of the possibility of spreading the virus, especially during the onset of active skin changes. contact with the eyes should be avoided when applying the cream to herpes sores on the lips and face. the preparation contains cetyl alcohol, stearyl alcohol, propylene glycol and parahydroxybenzoates, these components can cause local skin reactions (eg contact dermatitis), skin irritation or allergic reactions (possibly delayed).
Use during pregnancy and lactation. Due to insufficient data on the effect of the preparation on the course of pregnancy, it is not recommended to use the preparation during pregnancy and lactation.
Children. There are no data on the use in children.
The ability to influence the reaction rate when driving or working with other mechanisms. Does not affect.
Under the conditions of external use, no interactions were noted.
When applied topically, there were no cases of overdose.
At a temperature not higher than 25 ° C.