Dopegyt 250mg 50 tablets — Made in Hungary — Free Delivery

The preparation acting on the central mechanisms of regulation of blood pressure. penetrates the blood-brain barrier; metabolized with the formation of alpha-methylnorepinephrine, which stimulates postsynaptic α-adrenergic receptors of brain stem neurons in the central nervous system, which leads to inhibition of the vasomotor center. the hypotensive effect with prolonged use of the preparation is mainly associated with a decrease in the ovarian pressure, the minute volume of blood does not change. increases the rate of glomerular filtration and renal blood circulation, reduces the level of renin in the blood plasma. also causes a moderate decrease in cardiac output and heart rate. the effect of the preparation is manifested 2 hours after application and lasts 24–48 hours.

After oral administration, about 50% of the preparation is absorbed into the gastrointestinal tract. Protein binding - up to 20%. Up to 10% of the dose taken is metabolized to form alpha-methyldopa and alpha-methylnorepinephrine. It is excreted mainly by the kidneys. About 70% of the absorbed preparation is excreted in the urine in the form of methyldopa and its sulfoconjugates.

With prolonged use, the preparation can accumulate in the body. The half-life is no more than 8 hours; with renal failure, it increases. After oral administration, complete elimination of the preparation occurs after 36 hours. It is removed during hemodialysis, peritoneal dialysis.

Mild to moderate ar, ar in pregnant women.

The dose is set individually. as a rule, the initial dose of methyldopa for adults is 250 mg (1 tablet) 2-3 times a day for the first 2 days.

Then the daily dose is increased by 250 mg (1 tablet) sequentially every 2 days until an adequate level of blood pressure reduction is achieved. If necessary, increase the dose to 1–1.5 g / day. The maximum daily dose for adults is 3 g (12 tablets).

Children, if necessary, are prescribed Dopegit, starting with a dose of 10 mg / kg of body weight (in 2-4 doses), then the dose is selected individually, depending on the effect obtained. The maximum daily dose for children is 65 mg / kg of body weight.

Dopegit tablets should not be used in the case of:

• allergies to any component of the preparation;

• active form of hepatitis and / or liver failure, liver cirrhosis;

• autoimmune hemolytic anemia;

• pheochromocytomas;

• hyperprolactinemia;

• porphyrias;

• depression.

From the side of the cardiovascular system: peripheral edema, orthostatic hypotension, bradycardia.

From the side of the central nervous system: headache, dizziness, weakness, drowsiness, rarely - Parkinson's syndrome, hallucinations.

From the gastrointestinal tract: nausea, vomiting, dry mouth, diarrhea, constipation, pancreatitis, liver dysfunction, jaundice, colitis.

From the hematopoietic system: rarely - leukopenia and thrombocytopenia, autoimmune hemolytic anemia.

From the endocrine system: gynecomastia, galactorrhea, decreased libido, impotence.