GROPRINOSIN 500MG 50 TABS - MADE IN POLAND - FREE SHIPPING
Composition:
Dosage:
Duration of treatment
Contraindications:
Additional:
- transient increase in blood uric acid levels,
- increase in liver enzymes or blood urea nitrogen,
- Nausea with or without vomiting
- abdominal pain,
- itchy skin
- skin rash (as the only symptom),
- headaches,
- dizziness,
- tiredness or feeling unwell
- arthralgia.
Instructions For the use of medicine Groprinosin
Ingredients:
Active ingredient: Inosine pranobex
1 tablet contains 500 mg Inosine pranobex
Inactive ingredients: potato starch,
providone, magnesium stearate.
Medication form: tablets.
General physic-chemical properties: oval
tablets, white or cream color, with a middle line for splitting, 17 mm long, 7
mm wide.
Pharmaceutical group: anti-viral drug for
systematic treatment.
Pharmaceutical properties:
Immune stimulatory drug with antiviral
action. It is a complex, containing inosine and N,N-dimethylamino-2-propanol in
relation1:3.
The effectiveness of the complex is
determined by the presence of inosine, the second component increases its
availability to lymphocytes. Groprinosin stimulates biochemical processes in
macrophages. It increases production of interleukin. Strengthens the synthesis
of antibodies, enhances the proliferation of T-lymphocytes, T-helper cells.
It stimulates the chemotactic and
phagocytic activity of monocytes, macrophages and polymorphonuclear cells.
Groprinosin inhibits the replication of DNA and RNA viruses by binding with
ribosome cells and changes its stereochemical structure.
The drug was well tolerated. It has low
toxicity.
Groprinosin is recommended for patients
with poor immunity.
Pharmacokinetics
Absorption
After oral administration, the drug is well
absorbed from the gastrointestinal tract and is characterized by good
bioavailability.
Metabolism and excretion
Rapidly metabolized. Inosine is metabolized
by cycle, typical of purine nucleotides, to form uric acid, level in blood
serum which can sometimes increase. It may result in crystallization of uric acid
in the urinary tract. There were no drug accumulation in the body.
Complete elimination of the drug and its
metabolites happens during 48 hours.
Clinical characteristics:
- Immunodeficiency, caused by viral
infections in patients with normal and impaired immune systems, incl. disease,
caused by Herpes simplex virus types 1 and 2 (including genital herpes and cold
sores at other sites);
- viral respiratory infections;
- papilloma virus on skin;
- Subacute sclerosing panencephalitis.
- Cytomegalovirus
Do not use if:
You
have ever had an allergic reaction or hypersensitivity to this
product or any of its ingredients.
Drug Interactions:
The drug should not be used in conjunction
with immune depressants, xanthine oxidase inhibitor (allopurinol), loop
diuretics (torasemide, furosemide, ethacrynic acid). They increase the
concentration of uric acid in the urine.
Specific application:
Groprinosin shoul not be taken if the
following applies: hypersensitivity to one of drug ingredients; urolithiasis; gout;
chronic renal failure; pregnancy and lactation; children under 3 years. With
extra care medicine can be applied along with xanthineoxidase inhibitors,
diuretics, and also at an acute liver failure.
Usage during pregnancy or lactation:
There is no sufficient research or data on adverse
effects during pregnancy and lactation, therefore the drug should not be used
Usage while operating machinery or driving:
There is no sufficient research or data on
adverse effects during operating machinery or driving however side effects such
as dizziness should be considered and the drug should be taken with caution.
Use and dosage:
The drug should be administered orally. Dose depends on the patient’s weight, symptoms
and conditions. Adults and children over 12 years: 50 mg per 1 kg of weight
(usually 6-8 tablets divided into 3-4 doses), maximum daily dose 4g. Children
1-12 years: 50 mg per 1 kg of weight (usually 1 tablet per 10 kg for a child
weighing 10-20 kg). if the weight is over 20 kg adult daily dose can be given
divided in 3-4 doses, maximum daily dose 4g. the tablet can be dissolved in
water.
Treatment duration:
Acute condition: short term illness can be
treated for 5-14 days, if symptoms improve continue treatment for 1-2 days.
Chronic conditions: treatment may last 1-2 weeks after initial symptoms
improve. Recurrent chronic diseases: at the beginning of treatment the
same recommendations as for acute conditions may be applied. For supportive therapy daily dose can be
reduced to 500-1000 mg (1-2 tablets) a day. Treatment may be repeated as needed
Children:
The drug is recommended for children over 1 year old.
Overdose:
There are no reports of overdose. However
overdose may cause increase of uric acid in blood serum and urine. Symptomatic
treatment is recommended.
Side effects:
In case of hypersensitivity allergic
reaction is possible. Fatigue, dizziness, headache, sometimes – sleeplessness,
nervousness, drowsiness; Rash, itching; gout, joint pain; nausea, loss of
appetite, vomiting, sometimes – a lock, diarrhea; allergic reactions; polyuria;
increase of level of concentration of uric acid in urine and blood.
Shelf life: 3 years.
Do not use the product after expiration
date indicated on the package.
Storage: Store in original package in dry
place below 25C/ 77F away from t and children.
Packaging: 20 tablets per blister 2 (10x2) or 5 (10x5)
blisters per box.
Manufacturer: Gedeon Richter Poland
Manufacturer’s address: Yu. Ponyatovsky St,
5, Grodzinsk Mazovetsky 05-825, Poland
Distributor: Gedeon Richter Hungary
Distributor’s address: Demreya St, 19-21,
H-1103 Budapest Hungary
Tags: GROPRINOSIN
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