2 x FOTIL EYE DROPS 5ML — MADE IN FINLAND — FREE SHIPPING
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Description 2 x FOTIL EYE DROPS 5ML — MADE IN FINLAND — FREE SHIPPING
Product description
Fotil eye drops - is a combined preparation based on pilocarpine alkaloid and timolol
beta-adrenoblocker, the combined effect of which leads to a decrease in
intraocular pressure in various types of glaucoma, and also after surgical
interventions on the organ of vision
Fotil eye drops - combined antiglaucoma preparation.
Pilocarpine is an m-holinomimetic, with topical
application it reduces the smooth muscles of the circular muscle of the iris
and ciliary muscle, which leads to an increase in the angle of the anterior
chamber of the eye, a change in the configuration of the trabecular zone. This
helps to increase the outflow of intraocular fluid from the anterior chamber of
the eye and decrease the intraocular pressure.
Timolola maleate - beta-blocker, prevents the
stimulating effect of catecholamines on β-adrenergic receptors. Reduces intraocular pressure by reducing the
formation of intraocular fluid.
Pilocarpine and timolol with a combination in one
preparation mutually reinforce each other.
With topical application, Fotil reduces both increased
and normal intraocular pressure, irrespective of the presence of glaucoma.
After a single application of a single dose of Fotil, intraocular pressure
begins to decrease after 30 minutes, the maximum effect is usually achieved
after 2 hours, the effect of the preparation is maintained for 20 hours.
Pharmacokinetics
Timolol
Rapidly penetrates through the cornea.
Reducing the formation of intraocular fluid, reduces
the rate of excretion of pilocarpine from the eye.
Pilocarpine
Well penetrates through the cornea. C max in the
intraocular fluid is achieved after 30 min. Pilocarpine binds in most tissues
of the eye, which prolongs its half-life from the eye, which ranges from 1.5 to
2.5 hours. Pilocarpine is unchanged from the eye tissues along with the
intraocular fluid.
In blood plasma and liver quickly hydrolyzed into an
inactive form. T 1/2 from blood plasma - less than 0.5 h.
Indications:
- Open angle and angle-closure glaucoma.
- Glaucoma
associated with aphakia.
- Secondary
glaucoma.
- Increase in intraocular pressure in the
postoperative period.
- Glaucoma after surgery for cataracts.
- Pronounced increase in intraocular pressure
with risk of eye damage (including as part of combined antiglaucoma
therapy).
Contraindications:
- anterior
uveitis;
- sinus
bradycardia;
- AV blockade II and III degree;
- Decompensated
heart failure;
- cardiogenic
shock;
- bronchial
asthma;
- COPD;
- children and adolescents under 18 years
(due to the lack of data on the effectiveness and safety of the preparation
in children and adolescents);
- the condition immediately after ophthalmic
operations and other eye diseases, in which the narrowing of the pupil is
undesirable;
- hypersensitivity to the components of the preparation.
With caution should prescribe the preparation for
heart failure, cerebrovascular disorders, diabetes, hypoglycemia, retinal
detachment, myopia, thyrotoxicosis, before surgery under general anesthesia.
Special instructions:
The preparation is prescribed to patients who can not
compensate for increased intraocular pressure with monotherapy, in almost all
forms of glaucoma.
Caution should be given to the preparation in the
following cases:
- Patients
with cerebrovascular disorders.
- With
hypoglycemia.
- Before the operation under anesthesia.
Care should be taken when prescribing the preparation
to patients receiving beta-blockers inwards.
With prolonged use of the preparation in patients with
glaucoma may develop resistance to the active components of the preparation.
However, to the combined eye drops the degree of development of tolerance is
expressed less than to monocomponent antiglaucoma preparations.
Evaluation of the effectiveness of the preparation
should be carried out approximately 4 weeks after the start of treatment.
Measurement of intraocular pressure should be carried out at different times of
the day.
Due to the fact that the preparation contains a preservative,
patients wearing soft contact lenses should be removed before using drops. It
is recommended that you wait 15 minutes before reinserting contact lenses.
During the period of preparation use, dark adaptation
may worsen. The patient should be warned about the danger of movement in the
dark.
Use in Pediatrics
Clinical trials of the safety and efficacy of the use
of Fotila in children have not been conducted.
Results of experimental studies
In studies carried out on laboratory animals, there
was no mutagenic effect of timolol.
At present, there is no evidence that pilocarpine has
a mutagenic effect in the treatment of glaucoma in humans. However, in
experimental studies, signs of mutagenicity in pilocarpine have been
identified.
Impact on the ability to drive vehicles and manage
mechanisms
Drivers of vehicles must be careful when driving in
conditions of insufficient lighting, because the preparation can disrupt the
dark adaptation.
Suggested Use:
Assign 1 drop of the preparation Fotil to the affected
eye 2 times / day.
In some patients, stable decrease in intraocular
pressure is achieved only after several weeks of therapy. Therefore, when
evaluating the results of treatment, it is necessary to measure the intraocular
pressure approximately 4 weeks after the start of treatment. If the expected
decrease in intraocular pressure does not occur, Fotil forte should be
prescribed (Fotil forte drops drops of ophthalmic 5 ml capsule 1 Santen AO) or,
in view of the fact that further increasing of the dose does not give effect,
combined therapy with inhibitors of carbonic anhydrase for systemic use.
Before starting therapy with Fotil, treatment with
other antiglaucoma eye drops should be discontinued the day before.
Packaging:
- Comes in original packaging. Item is brand
new and unopened.
Storage:
- Keep away from direct sunlight.
- Keep locked and away from children.
- Store in dry place at room temperature.
- Do not exceed storage temperature higher
than 25 C
Important notice- the outer box design may vary before prior notice!
Tags: FOTIL
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