Pramistar 600 mg 20 tablets — Made in Germany — Free Delivery

(Pramistar )
Pramistar 600 mg 20 tablets — Made in Germany — Free Delivery
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Berlin-Chemie Brand: Berlin-Chemie

Pharmacological properties

Pharmacodynamics. Pramiracetam is a nootropic preparation that improves memory and learning ability. the mechanism of action of the preparation is not fully determined. by acting on cholinergic receptors and choline metabolism, pramiracetam stimulates neuronal activity. pramiracetam has no inhibitory effect on the central nervous system and has no effect on the autonomic nervous system. pramiracetam also has antidepressant effects. During clinical trials in patients with mild to moderate senile dementia, pramiracetam increased concentration, improved learning, memorization, orientation and other mental activity.

Pharmacokinetics. Pharmacokinetic studies in humans have shown that the preparation is rapidly and almost completely absorbed in the gastrointestinal tract. Cmax in blood plasma is achieved after 2-3 hours. T½ is 4-6 hours. Pharmacokinetic parameters in elderly and young patients are similar. However, along with a decrease in creatinine clearance, the clearance of pramiracetam decreases. Pramiracetam does not bind to blood plasma proteins and is excreted in the urine in an almost unchanged state.


Decreased ability to concentrate and memory impairment of degenerative or vascular origin, especially in the elderly.


The recommended dose is 600 mg every 12 hours. The total daily dose should not exceed 1200 mg. a clinically significant effect can be expected no earlier than 4–8 weeks of treatment.

Elderly patients. No dose adjustment is required.

Patients with renal insufficiency. In renal failure, there is a delay in the excretion of pramiracetam. The clinical significance of slowing the excretion of pramiracetam in renal failure has not been determined. Therefore, the preparation should be used in patients with renal insufficiency with caution, and if undesirable effects appear, cancel it, since these may be signs of accumulation of the active substance in the body. The use of Pramistar in severe renal failure is contraindicated.


Hypersensitivity to the active substance or other components of the preparation, cerebral hemorrhage, severe renal failure, liver failure.

Side effects

From the digestive system: dry mouth, stool incontinence, dyspepsia, nausea, pain in the upper stomach;

  • on the part of metabolism and nutrition: decreased appetite;
  • on the part of the musculoskeletal system and connective tissue: painful muscle spasms;
  • from the nervous system: dizziness, tremor;
  • from the side of the psyche: dysphoria, confusion, insomnia, psychomotor agitation;
  • from the kidneys and urinary system: urinary incontinence.

Special instructions

In patients with renal insufficiency, there is a delay in the excretion of pramiracetam. therefore, the preparation should be used with caution in patients with renal insufficiency. when side effects appear, it is necessary to cancel it, since these reactions can be signs of the accumulation of an active substance in the body.

Piracetam (as a compound of the same pharmacological class with pramiracetam) affects platelet aggregation and function, as well as other indicators of hemostasis. Therefore, Pramistar should be used with caution in conjunction with anticoagulants or platelet aggregation inhibitors, as well as in patients with bleeding disorders.

Use during pregnancy and lactation. The use of pramiracetam during pregnancy and lactation is contraindicated.

Children. The study in children was not carried out, therefore, the preparation is not recommended for use in children.

The ability to influence the reaction rate when driving or working with other mechanisms. Studies of the ability to influence the reaction rate when driving or working with other mechanisms have not been carried out. However, among the adverse reactions of pramiracetam, dizziness, psychomotor agitation, tremors and confusion are indicated. Therefore, patients should be warned about the possible impact on the ability to drive vehicles and work with other mechanisms.


Interactions with cardiac glycosides, xanthines, anticoagulants and APF inhibitors were not detected in patients taking 600 mg of pramiracetam every 12 hours.

When patients were prescribed active substances of the same pharmacological group with pramiracetam (for example, piracetam), confusion, irritability and sleep disorders were noted simultaneously with thyroid gland extract (T3 + T4). In a published simple blind study in patients with severe recurrent venous thrombosis, piracetam (9.6 g / day) did not alter the dose of acenocoumarol to achieve the required International Normalized Ratio of 2.5–3.5. But compared with the action of only acenocoumarol, the addition of piracetam (9.6 g / day) significantly reduced platelet aggregation, beta-thromboglobulin release, fibrinogen and von Willebrand factor levels (VIII: C, VIII: vW: Ag, VIII: vW: Rco), and also the viscosity of blood and blood plasma.


There are no reports of overdose. if the recommended therapeutic doses are significantly exceeded, symptomatic therapy should be carried out.

Storage conditions

At a temperature not higher than 30 ° C.

Shelf life is 3 years. Do not use after the expiration date printed on the package.

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