Antiflu 12 tablets — Made in Germany — Free Delivery

In severe cases, especially with the simultaneous use of ethanol, liver damage (hepatocellular necrosis) and deterioration of its function may occur, which can progress to hepatic encephalopathy, hepatic coma, cerebral edema and death. Clinical signs of liver damage may not appear for 12–48 hours after an overdose. Disorders of glucose metabolism, hypokalemia, and metabolic acidosis (including lactic acidosis) may occur. The symptoms of metabolic acidosis are deep, rapid or labored breathing, nausea, vomiting, and loss of appetite. You should immediately consult a doctor if these symptoms appear. An increase in the activity of liver transaminases and an increase in the prothrombin index, hemorrhage. Liver damage in an adult can develop after ingestion of ≥10 g of paracetamol and 150 mg / kg of body weight in a child. Frequent clinical manifestations that appear after 3-5 days include jaundice, fever, hemorrhagic diathesis, hypoglycemia, hepatic breath odor, liver failure.

The use of ≥5 g of paracetamol can lead to liver damage in patients with risk factors: long-term treatment with carbamazepine, phenobarbital, phenytoin, primidone, rifampicin, St. John's wort or other preparations that induce liver enzymes; regular intake of excess amounts of ethanol; glutathione cachexia (digestive disorders, cystic fibrosis, HIV infection, starvation, cachexia).

With prolonged use in high doses, aplastic anemia, pancytopenia, agranulocytosis, neutropenia, leukopenia, thrombocytopenia are possible.

Urgent care. The patient should be taken to hospital immediately, even if there are no early symptoms of overdose. Symptoms may be limited to nausea and vomiting, or may not reflect the severity of the overdose or the risk of organ damage. Treatment with activated charcoal should be considered if an excessive dose of paracetamol has been taken within 1 hour. The plasma concentration of paracetamol should be measured 4 hours or later after ingestion (earlier concentrations are unreliable). Gastric lavage should be within 6 hours after a suspected acetaminophen overdose. Cytostatic effects can be reduced by administering oral methionine or intravenous administration of cysteamine or N-acetylcysteine ​​within 8 hours after overdose. The effectiveness of the antidote decreases sharply after this time.

Overdose due to the action of phenylephrine and chlorpheniramine maleate can cause increased sweating, psychomotor agitation or depression of the central nervous system, irritability, anxiety, headache, dizziness, drowsiness, insomnia, nausea, vomiting, tremor, impaired consciousness, cardiac arrhythmias, tachystolic heart, hyperreflexia, increased blood pressure, convulsions, coma.

In case of an overdose of chlorpheniramine maleate, atropine-like symptoms can be observed: mydriasis, photophobia, dry skin and mucous membranes, fever, intestinal atony. Inhibition of the central nervous system is accompanied by respiratory disorders and disturbances in the work of the cardiovascular system (a decrease in pulse rate, a decrease in blood pressure up to the development of vascular insufficiency).

In case of overdose, symptomatic therapy is necessary, in severe hypertension, the use of α-adrenergic receptor blockers.

In its original packaging at a temperature not exceeding 25 ° C.