Combispasm Gastrocomfort 20 tablets — Made in India — Free Delivery

Pharmacodynamics. Dicyclomine hydrochloride has an antispasmodic effect (eliminates spasm of smooth muscles in the gastrointestinal tract, abdominal pain associated with this spasm or stretching of the gastrointestinal wall) and an antisecretory effect on the excretory glands. the action of dicyclomine consists in a specific anticholinergic (antimuscarinic) effect on cholinergic receptors, as well as a direct antispasmodic effect on smooth muscles.

Simethicone is a surfactant, antifoam agent. The mechanism of action is based on a decrease in the surface tension of gas bubbles, promotes the free removal of gases from the gastrointestinal tract or their absorption by the intestinal wall. Simethicone improves the quality of radiographs and sonograms, provides a better distribution of contrast agents on the intestinal mucosa.

Pharmacokinetics. Dicyclomine hydrochloride, when taken orally, is rapidly absorbed in the gastrointestinal tract, Cmax in the blood plasma is reached after 60–90 minutes, excreted mainly in the urine (79.5% of the administered dose), partially in the feces (8.4%). T½ - 1.8 hours. The average volume of distribution is 3.65 l / kg.

Simethicone is physiologically and chemically an inert substance, it is not absorbed and is excreted unchanged after passing through the digestive tract.

Treatment for conditions accompanied by spasm of smooth muscles of the gastrointestinal tract and flatulence, as well as associated abdominal pain.

Treatment for spastic conditions of the gastrointestinal tract, including colitis, intestinal colic, irritable bowel syndrome, spastic constipation.

In complex treatment for organic diseases of the gastrointestinal tract with colitis, diverticulitis, enteritis, gastritis, peptic ulcer.

Adults and children over the age of 12 years: the preparation is prescribed 1 tablet up to 4 times a day before or after meals. the maximum daily dose is 4 tablets. the duration of treatment is up to 5 days.

Hypersensitivity to active substances or other components of the preparation, intestinal obstruction, obstructive diseases of the urinary tract, prostate adenoma with difficulty urinating, renal failure, obstructive gastrointestinal diseases, severe ulcerative colitis or toxic megacolon, reflux esophagitis, unstable state of the cardiovascular system with acute bleeding, glaucoma, myasthenia gravis, thyrotoxicosis, heart failure.

From the digestive system: dry mouth, loss of taste, anorexia, nausea, vomiting, indigestion, bloating, abdominal pain, constipation.

From the side of the central nervous system: ringing in the ears, headache, drowsiness, weakness, nervousness, psychosis, numbness, dizziness, coma, confusion and / or agitation (especially in the elderly), dyskinesia, insomnia, disorientation, short-term memory loss, hallucinations , dysarthria, ataxia, euphoria, inadequate emotional reactions (the severity of symptoms decreases 12-24 hours after dose reduction).

From the side of the organ of vision: blurred vision, double vision, dilated pupils, paralysis of accommodation, increased intraocular pressure (short-term atropine-like effects that disappear after discontinuation of dicycloverine).

Skin / allergic reactions: hypersensitivity reactions, including allergic dermatitis, pruritus, rash, urticaria, erythema, preparation-induced idiosyncrasy, angioedema, anaphylactic shock.

From the genitourinary system: difficulty urinating, urinary retention.

From the side of the cardiovascular system: tachycardia, increased heart rate.

From the respiratory system: shortness of breath, apnea, nasal congestion.