Diclofenac sodium is a non-steroidal anti-inflammatory and anti-rheumatic agent.

The preparation for intramuscular administration is intended for the treatment of:

The preparation, when administered as an intravenous infusion, is intended for the treatment or prevention of postoperative pain.

active substance: diclofenac;

1 ml of solution contains diclofenac sodium 25 mg;

excipients: mannitol, sodium metabisulfite (E 223), benzyl alcohol, propylene glycol, 1 M sodium hydroxide solution, water for injections.

Hypersensitivity to diclofenac, sodium metabisulfite or any other components of the preparation.

History of bleeding or perforation of the digestive tract associated with previous treatment with non-steroidal anti-inflammatory preparations (NSAIDs).

Active peptic ulcer/bleeding or a history of recurrent peptic ulcer/bleeding (two or more separate episodes of established ulceration or bleeding).

Like other NSAIDs, diclofenac is contraindicated in patients in whom the use of ibuprofen, acetylsalicylic acid or other non-steroidal anti-inflammatory preparations provokes attacks of bronchial asthma, angioneurotic edema, urticaria, acute rhinitis/nasal polyps, bronchospasm or other allergic reactions.

Inflammatory bowel diseases (for example, Crohn's disease or ulcerative colitis).

Acute stomach or intestinal ulcer; gastrointestinal bleeding or perforation.

Treatment of perioperative pain in coronary artery bypass grafting (or the use of an artificial blood circulation device).

Ischemic heart disease in patients with angina pectoris and myocardial infarction.

Cerebrovascular diseases in patients who have suffered a stroke or have episodes of transient ischemic attacks.

Diseases of peripheral arteries.

In this dosage form, the preparation is contraindicated for children.

III trimester of pregnancy.

From the hematopoietic system: thrombocytopenia, leukopenia, anemia (including hemolytic and aplastic anemia), agranulocytosis.

From the side of the immune system: hypersensitivity, anaphylactic and anaphylactoid reactions (including arterial hypotension and shock), angioedema (including facial edema).

From the mental side: disorientation, depression, insomnia, insomnia, nightmares, irritability and other mental disorders.

From the side of the nervous system: headache, dizziness, drowsiness, fatigue, paresthesia, memory impairment, convulsions, anxiety, tremor, aseptic meningitis, taste disorder, stroke, confusion, hallucinations, sensitivity disorders, general malaise.

On the part of the organs of vision: vision disorder, blurred vision, diplopia, optic neuritis.

On the part of hearing organs: vertigo, ringing in the ears, hearing impairment.

From the cardiovascular system: palpitations, chest pain, heart failure, myocardial infarction, arterial hypertension/hypotension, vasculitis, Kounis syndrome.

From the respiratory system: asthma (including dyspnea), bronchospasm; pneumonitis

From the digestive tract: nausea, vomiting, diarrhea, dyspepsia, abdominal pain, flatulence, anorexia, gastritis, gastrointestinal bleeding, vomiting with blood impurities, hemorrhagic diarrhea, melena; stomach or intestinal ulcers with or without bleeding or perforation (sometimes fatal, especially in elderly patients) that may lead to peritonitis; colitis (including hemorrhagic colitis and exacerbation of ulcerative colitis or Crohn's disease), constipation, stomatitis (including ulcerative stomatitis), glossitis; pharyngeal disorder similar to the diaphragm of intestinal structures; esophageal disorders, membranous intestinal strictures, pancreatitis; ischemic colitis.

From the side of the hepatobiliary system: an increase in the level of transaminases, hepatitis, jaundice, impaired liver function, acute hepatitis, hepatonecrosis, liver failure.

The dose should be selected individually, starting with the minimum effective dose, and should be taken for the shortest possible time.

Diclofenac Sodium, solution for injection, is not used for longer than 2 days. If necessary, the treatment can be continued with diclofenac tablets or suppositories.

Each ampoule is intended for single use only. The solution should be used immediately after opening the ampoule. Any unused content must be disposed of.

In order to prevent damage to nerves or other tissues at the site of intramuscular injection, the following rules must be followed.

The dose is usually 75 mg (1 ampoule) per day by deep injection into the upper outer sector of the gluteus maximus muscle. In severe cases (for example, colic), the daily dose can be increased to two injections of 75 mg, between which an interval of several hours should be observed