DUOTRAV EYE DROPS 2,5ML — MADE IN BELGIUM — FREE SHIPPING
Product description
DuoTrav eye
drops - a combined preparation for lowering
intraocular pressure, used in ophthalmology locally.
Travoprost, a synthetic analogue of prostaglandin
P2-alpha, is a highly selective agonist of prostaglandin FP receptors and
reduces intraocular pressure by increasing the outflow of aqueous humor. The
main mechanism of action of the preparation is associated with an increase in
out-scleral outflow. Has no significant effect on the production of aqueous
humor.
Timolol is a non-selective beta-adrenergic blocker
without sympathomimetic activity, does not have a direct depressive effect on
the myocardium, does not have membrane-stabilizing activity. With topical
application reduces intraocular pressure by reducing the formation of watery
moisture and a slight increase in its outflow.
Intraocular pressure decreases approximately 2 hours
after application, and the maximum effect is achieved after 12 hours. A
significant decrease in intraocular pressure can persist for 24 hours after a
single application of the preparation.
Pharmacokinetics
Travoprost and timolol are absorbed through the cornea
of the eye. In the cornea, hydrolysis of herboprost is carried out to a
biologically active form - travoprost acid.
Travoprost after local application is quickly removed
from the plasma for an hour - the concentration in the blood plasma drops below
the detection threshold - less than 0.01 ng / ml (can vary from 0.011 ng / ml
to 0.02 ng / ml).
The maximum concentration (C max) of timolol in the
blood plasma is 0.692 ng / ml and is maintained to the detection threshold for
12 hours, and timaxol T max is reached within one hour after topical
application.
T 1/2 of timolol is 4 hours after topical application
of DuoTrava.
Travoprost is excreted as inactive metabolites mainly
with bile (61%). The free acid of travoprost and its metabolites are excreted
by the kidneys. Less than 2% of travoprost is found in the urine as a free
acid.
Timolol and the resulting metabolites are excreted
mainly by the kidneys. About 20% of timolol is excreted unchanged, the rest -
in the form of metabolites.
Indications:
Decreased elevated intraocular pressure with
open-angle glaucoma and intraocular hypertension in patients with beta-blockers
or analogs resistant to monotherapy.
Contraindications:
- Hypersensitivity to the components of the preparation.
- Bronchial
asthma.
- Bronchial
asthma in history.
- Severe chronic obstructive pulmonary
disease.
- Hyperreactivity
of the bronchi.
- Sinus
bradycardia.
- Atrioventricular blockade of II-III degree.
- Decompensated
chronic heart failure.
- Cardiogenic
shock.
- Allergic rhinitis of severe course.
- Dystrophy
of the cornea.
- Hypersensitivity to a group of
beta-blockers.
- Pregnancy.
- The
period of breastfeeding.
- Children
under 18 years.
Carefully:
- Neovascular, closed-angle, narrow-angle
glaucoma.
- Pigment
and congenital glaucoma.
- Open angle glaucoma with pseudo-aphasia.
- Pseudoexfoliation
glaucoma.
- Ophthalmic
inflammatory diseases.
- Afakia.
- Pseudofakia with a rupture of the posterior
capsule of the lens.
- Patients with a risk of developing cystoid
macular edema, iritis, uveitis.
- Patients with atopy or with severe
anaphylactic reactions to various allergens in a history who receive
beta-blockers may be resistant to conventional doses of epinephrine in the
treatment of anaphylactic reactions.
Special instructions:
Travoprost and timolol may undergo systemic
absorption. Timolol with local use can cause the same side effects from the
cardiovascular and respiratory systems, as well as systemic beta-blockers. It
is necessary to monitor the patient's condition before and during therapy with
timolol. Cases of severe respiratory and cardiovascular disorders, including
death from bronchospasm in patients with bronchial asthma and death from heart
failure with timolol, are described.
Beta-blockers should be used with caution in patients
with a tendency to hypoglycemia or diabetes (especially with diabetes
mellitus), because these preparations can mask the symptoms of acute
hypoglycemia.
Beta-adrenoblockers can mask symptoms of
hyperthyroidism and cause peripheral and central circulatory disorders and
hypotension, as well as worsening of the condition with Prinzmetal angina
pectoris.
Before the planned operation, beta-blockers should be
gradually (not instantaneously!) Canceled 48 hours before the general
anesthesia, tk. during general anesthesia, they can reduce the sensitivity of
the myocardium to sympathetic stimulation necessary for the work of the heart.
Do not touch the tip of the dropper bottle to any
surface to avoid contamination of the dropper and its contents. The bottle must
be closed after each use.
Local action
Travoprost can cause a gradual change in eye color by
increasing the amount of brown pigment in melanocytes. Before starting
treatment, patients should be informed about the possibility of changing eye
color. Treatment of only one eye can lead to permanent heterochromia. Long-term
effects on melanocytes and the effects of this effect are currently unknown.
The change in the color of the iris of the eyes is slow and may go unnoticed
for a number of months or years.
This effect is revealed mainly in patients with mixed
iris coloration, for example, blue-brown, gray-brown, green-brown or
yellow-brown; However, it can also be observed in patients with brown eyes.
Typically, brown pigmentation spreads concentrically around the pupil to the
periphery of the iris of the eyes, while the entire iris or parts of it can
acquire a more intense brown color. After the preparation was discontinued,
there was no further increase in the amount of brown pigment, but the already
developed color change may be irreversible.
The preparation can cause darkening, thickening and
lengthening of eyelashes or an increase in their number; rarely - darkening of
the skin of the eyelids. The mechanism of these changes is not currently
established. The preparation contains a preservative of benzalkonium chloride,
which can be absorbed by contact lenses. Before using the preparation, the lens
should be removed and installed back no earlier than 15 minutes after the preparation
is used.
Impact on the ability to drive vehicles and manage mechanisms
If the patient after the application of the preparation
temporarily reduces clearness of vision, it is not recommended to drive the car
and engage in activities requiring increased attention before its restoration.
Suggested Use:
The preparation is instilled in 1 drop in the
conjunctival sac of the eye 1 time per day, in the evening or in the morning at
the same time.
To reduce the risk of developing systemic side
effects, it is recommended after the instillation of the preparation to squeeze
the nasolacrimal canal by pressing in the area of its projection at the inner
corner of the eye.
If the dose has been missed, the treatment should be
continued with the next dose. The daily dose of the preparation should not
exceed 1 drop in the conjunctival sac of the eye 1 time per day.
Packaging:
- Comes in original packaging. Item is brand
new and unopened.
Storage:
- Keep away from direct sunlight.
- Keep locked and away from children.
- Store in dry place at room temperature.
- Do not exceed storage temperature higher
than 25 C
Important notice- the outer box design may vary before prior notice!
Tags: DUOTRAV
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