EGOLANZA 10MG 28 PILLS — MADE IN HUNGARY — FREE SHIPPING
Egolanza (Olanzapinum, Olanzapine) - antipsychotic (neuroleptic).
Olanzapine is an antipsychotic (neuroleptic) with a wide spectrum of pharmacological effects on a number of receptor systems. It has an affinity with serotonin (5-HT2A / C 5NTZ, 5NT6), dopamine (D1, D2, D3, D4, D5), muscarinic (M1-5), adrenergic (alpha 1) and histamine (H1) receptor.
Revealed antagonism to serotonin (5HT), dopamine, and cholinergic receptors. Has a pronounced affinity and activity against 5NTt serotonin receptors in comparison with dopamine D2 receptors.
Meyulimbicheskih selectively reduces anxiety (A10) dopaminergic neurons, has little effect on striatal (A9) nerve pathways involved in the regulation of motor function. Reduces conditioned defensive reflex in lower doses than the dose causing catalepsy. It enhances the anti-anxiety effect during "anxiolytic" test. Significantly reduces productivity (including delusions, hallucinations) and negative symptoms.
Schizophrenia (aggravation, maintenance and long-term preventive treatment). Bipolar disorder (monotherapy or in combination with preparations or Li + valytroevoy acid): acute manic or mixed episodes with / without psychotic symptoms and with / without rapid phase shifts.
Recurrence of bipolar disorder and the prevention of recurrence of bipolar disorder (for efficacy in the treatment of the manic phase).
Hypersensitivity to the active agent or any of the components. Angle-closure glaucoma. Psychosis and / or behavioral disturbances associated with dementia. Lactation. Children's age (up to 18 years due to insufficient clinical data). Lactose intolerance, lactase deficiency or glucose-galactose malabsorption (product contains lactose).
Liver failure, renal failure, prostatic hyperplasia, epilepsy, convulsions in history, myelosuppression (including leukopenia, neutropenia). myeloproliferative disorders, hypereosinophilic syndrome, paralytic ileus, pregnancy, cardiovascular and cerebrovascular disease, or other conditions predisposing to hypotension, inherent increase in the QT interval on the electrocardiogram (ECG) (increasing corrected-interval QT (the QTc) on the ECG), or nachichii conditions with the potential to cause an increase in QT intervata (for example, co-administration of preparations prolonging QT interval, congestive heart failure, hypokalemia, hypomagnesemia), advanced age, and concomitant use of other preparations of the central action; immobilization.
During antipsychotic preparations improved the clinical condition of patients can occur within a few days or weeks. During this period, patients in need of careful observation.
Psychosis and / or behavioral disturbances associated with dementia
Olanzapine is not approved for the treatment of psychosis and / or behavioral disturbances associated with dementia, and this preparation is not recommended in these patients because of the increased risk of death and cerebrovascular accidents. When receiving olanzapine in elderly patients with psychosis were observed on dementia cerebrovascular accident (stroke, transient ischemic attack), including fatalities. These patients had preexisting risk factors (cerebrovascular accident (in history), transient ischemic attack, hypertension, smoking), and related diseases and / or receiving preparations by the time associated with cerebrovascular disorders.
The use of Olanzapine is not recommended for the treatment of psychosis associated with taking dopamine agonists in patients with Parkinson's disease.
Neuroleptic malignant syndrome (NMS)
In the treatment of neuroleptic (including olanzapine) may develop neuroleptic malignant syndrome. Clinical manifestations of NMS are fever, muscle rigidity, altered mental status, autonomic instability functions (non-permanent levels of heart rate and blood pressure, tachycardia, sweating, cardiac arrhythmia). Additional symptoms may be increased levels of creatine phosphokinase, myoglobinuria (rhabdomyolysis) and acute renal failure. With the development of the patient's signs and symptoms of NMS, or the appearance of unexplained fever without additional clinical manifestations of NMS should cancel all antipsychotics, including olanzapine.
Hyperglycemia and diabetes
It noted a higher prevalence of diabetes mellitus in patients with schizophrenia. Very rarely, there have been cases of hyperglycemia of diabetes or worsening of pre-existing diabetes mellitus, ketoacidosis and diabetic coma. Not established a causal relationship between antipsychotic preparations and these states. It is recommended clinical monitoring of patients with diabetes mellitus or with risk factors for its development.
Changes in lipid levels
If you change the levels of lipids in patients receiving olanzapine should be given appropriate treatment, especially in patients with dyslipidemia, or risk factors for lipid metabolism disorders.
Despite the fact that olanzapine in vitro has anticholinergic activity, due to limited clinical experience with olanzapine in patients with concomitant diseases, we recommend caution in the appointment of the preparation to patients with prostatic hypertrophy, paralytic ileus, and other similar conditions.
Particular caution is required when increasing the activity of hepatic transaminases, ALT and / or ACT in patients with hepatic insufficiency or receiving treatment for a potentially hepatotoxic preparations. Observation of the patient is required and, if necessary, a dose reduction. In identifying hepatitis (including hepatocellular, cholestatic or mixed liver injury), olanzapine should be discontinued.
Olanzapine should be used with caution in patients with a reduction in the number of white blood cells, including neutrophils; with signs of depression or toxic disorders of the bone marrow under the influence of preparations (in history); with inhibition of bone marrow function due to concomitant disease, radio- or chemotherapy (in history); with hypereosinophilic or myeloproliferative disease. Neutropenia is often observed in the concomitant use of olanzapine and valproate. The use of olanzapine in patients with klozapinzavisimoy neytroieniey or agranulocytosis (in history) was not associated with recurrence of these violations.
Stopping the preparation
In a dramatic olanzapine in very rare cases (
As in the case of other antipsychotic preparations during treatment with olanzapine should be careful, if this preparation is given together with preparations that prolong the interval of the QTc, particularly in elderly patients, patients with a syndrome of congenital lengthening of the QT, congestive heart failure, cardiac hypertrophy, hypokalaemia , hypomagnesemia, or prolongation of the QT family history.
Avoid the simultaneous use of other antipsychotic preparations or medicines, also prolong the QT interval or cause hypokalemia.
Coincidence of olanzapine and venous thromboembolism reported in rare cases (less than 0.01%). Causation symptoms of venous thromboembolism and olanzapine has not been established. However, since patients with schizophrenia often have acquired venous thromboembolism risk factors, should identify all possible risk factors for venous thromboembolism, such as immobility of patients and to take preventive measures.
Olanzapine should be used with caution in patients with a history of seizures or are exposed to factors that reduce the seizure threshold. Seizures in patients treated with olanzapine, are rare. In most of these cases are registered seizures in history or risk factors for seizures.
With the development of symptoms of tardive dyskinesia recommended dose reduction or withdrawal of olanzapine. The symptoms of tardive dyskinesia can grow or manifest after discontinuation of the preparation.
In clinical trials of olanzapine observed infrequently orthostatic hypotension in elderly patients. As in the case of receiving other antipsychotic preparations, it is recommended to periodically measure blood pressure in patients older than 65 years.
Applications in Pediatrics
Olanzapine is not recommended for use in the treatment of children and adolescents. Studies in patients aged 13-17 years showed various adverse reactions, including weight gain, metabolic parameters change and increase the level of prolactin. Long-term outcomes of these events have not been studied and remain unknown.
This product contains lactose, therefore it should not be administered to patients with rare hereditary disorders galactose intolerance, hereditary lactase deficiency or glucose Sami-galactose malabsorption. Caution should be exercised when olanzapine in combination with other centrally acting preparations and ethanol.
Inside, regardless of meals, once - 5-20 mg / day. In schizophrenia in adults recommended initial dose - 10 mg / day. In acute mania associated with bipolar disorder in adults - 15 mg / day (1x) alone or 10 mg / day (1 time) in combination with preparations Li + or valproic acid (maintenance therapy at the same dose).
Prevention of relapse of bipolar disorder: The recommended starting dose is 10 mg per day. Patients previously treated with olanzapine for the treatment of manic episode should continue treatment at the same dose for relapse prevention. In the presence of a new manic, mixed, or depressive episode olanzapine should continue (if necessary specifying dose); in the presence of clinical indications should be added to appoint agents to eliminate mood disorders.
In the treatment of schizophrenia, manic episode and for the prevention of recurrence of bipolar disorder, the daily dose may subsequently be adjusted within the range of 5 to 20 mg based on the clinical condition of the particular patient. Dose adjustment over a value recommended as the initial dose, is recommended only after careful clinical analysis, and should usually occur at intervals of at least 24 hours.
Prior to discontinuation of olanzapine should gradually reduce the dose. The maximum daily dose of olanzapine 20 mg.
Smokers should be prescribed at the same doses as the non-smoking patients. If there is more than one factor that can cause a slowing metabolism (female gender, older age, non-smoking patients) should consider the need to reduce the initial dose of 5 mg / day. If necessary, a further dose increase may with caution.
Symptoms: tachycardia, agitation / aggression, articulation disorder, extrapyramidal disorders, depression of varying severity of consciousness (from sedation to coma), delirium, seizures, neuroleptic malignant syndrome, respiratory depression, aspiration, increased or decreased blood pressure, arrhythmia, heart failure and breathing.
The minimum dose for acute overdose fatalities was 450 mg, the maximum dose with a favorable outcome (survival) - 1500 mg.
Treatment: gastric lavage, the appointment of activated charcoal, symptomatic treatment, the maintenance of respiratory function.
Should not be used sympathomimetics (including noradrenaline, dopamine) which are agonists of the beta adrenergic receptors (stimulation of these receptors may worsen AD reduction). Careful medical supervision and monitoring should continue until the patient recovers.
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- Keep away from direct sunlight.
- Keep locked and away from children.
- Store in dry place at room temperature.
- Do not exceed storage temperature higher than 25 C
Important notice- the outer box design may vary before prior notice!
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