Gynoflor 12 vaginal tablets — Made in Switzerland — Free Delivery
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Description Gynoflor 12 vaginal tablets — Made in Switzerland — Free Delivery
Pharmacological properties
Pharmacodynamics. Lactobacilli acidophili are one of the dominant flora species in the vagina of a healthy woman. Lactobacilli have a protective function in the vagina. they ferment the glycogen of the vaginal epithelium to lactic acid. Acidic environment (pH 3.8-4.5), which is formed as a result, creates unfavorable conditions for the colonization and development of pathogenic microorganisms and provides optimal conditions for the reproduction of lactobacilli. In addition to lactic acid, lactobacilli produce hydrogen peroxide and bacteriocins, which also inhibit the development of pathogenic microorganisms.
Estriol is an endogenous estrogenic hormone that selectively affects the vagina and does not affect the endometrium. Estriol contained in Gynoflora ensures the proliferation of the vaginal epithelium. The proliferating and mature epithelium is a physiological barrier and contains glycogen, a nutrient substrate for Lactobacilli. With hormonal disorders, which more often occur in older women, as well as with inflammatory processes in the vagina, the vaginal epithelium is damaged and the amount of glycogen decreases. Exogenous estriol, even at a low dose, leads to the restoration of proliferating and mature epithelium and provides a glycogen reserve for the nutrition of Lactobacilli.
Violation or destruction of the physiological vaginal flora is mainly due to local or systemic treatment with anti-infectious agents, serious systemic diseases, poor hygiene and vaginal infections. In a non-physiological vaginal environment, the number of Lactobacilli may decrease or they may even disappear, their protective function is not realized.
The therapeutic effect of Gynoflora is manifested in the restoration of the vaginal microflora by introducing exogenous Lactobacilli and improving the state of the vaginal epithelium by introducing exogenous estriol. As a result, the physiological balance in the vagina and vaginal epithelium is restored. Lactobacillus acidophilus and estriol act topically, exclusively in the vagina.
Lactose, which is found in vaginal tablets as a filler, can also be fermented by Lactobacilli to lactic acid. Reproduction of Lactobacilli and recolonization of the vagina by these bacteria begin after the first application of the preparation.
Pharmacokinetics. As soon as the vaginal tablet interacts with the vaginal secretion, it begins to break down, freeze-dried bacteria and estriol are released. Experimental studies in vitro have shown that Lactobacilli restore their metabolism and lower vaginal pH within a few hours.
The positive estrogenic effects caused by estriol appear quickly, and during the course of treatment (6–12 days), the condition of the proliferating and mature vaginal epithelium gradually improves.
After 12-day use of vaginal tablets (at the end of treatment with Gynoflor 1 time per day), the peak level of unbound estriol in the blood plasma was not increased compared to the baseline level.
No accumulation of estriol was detected during 12 days of treatment. The concentration of unbound estriol in the blood plasma after repeated use of Gynoflor was within the normal boundaries of the endogenous hormone level in the blood plasma. Estriol therapy does not affect the plasma concentration of estrone and estradiol, since estriol is the end product of their metabolism.
Due to the low dose (0.03 mg), local application and the limited duration of treatment (6-12 days), estriol does not accumulate and the systemic effect of estrogen is unlikely.
Indications
Restoration of the vaginal flora of lactobacillus after local and / or systemic treatment with anti-infectious or chemotherapeutic agents; atrophic vaginitis due to estrogen deficiency during menopause and postmenopause or concomitant treatment during systemic hormone replacement therapy; mild to moderate cases of bacterial vaginosis and candidiasis, vaginal discharge of unknown origin (fluor vaginalis), in which the use of anti-infective therapy is not necessary; preventive treatment of recurrent vaginal infections.
Application
Restoration of lactobacillus flora after local and / or systemic treatment with anti-infectious or chemotherapeutic agents, fluor vaginalis (vaginal discharge), vaginal infections: 1-2 vaginal tablets daily for 6-12 days. vaginal tablets must be inserted deep into the vagina in the evening before bedtime. it is better to do this lying on your back, with your knees slightly bent.
Treatment should be suspended for the duration of menstruation, and then continued again.
Atrophic vaginitis, vaginal discharge (Fluor vaginalis) in postmenopausal period: 1 vaginal tablet daily for 12 days, then a maintenance dose is applied - 1 vaginal tablet 1-2 times a week. Regular use of Gynoflora for atrophic changes in the vaginal epithelium is necessary for the prevention of atrophic vaginitis.
Treatment of recurrent vaginal infections: The recommended dose is 1 vaginal tablet daily for 12 days.
Contraindications
Hypersensitivity to active ingredients or any of the excipients of the preparation; malignant neoplasms (estrogen-dependent malignant tumors) of the breast, uterus, or vagina; endometriosis (suspected or diagnosed); vaginal bleeding of unknown origin; girls before puberty.
Side effects
General disorders and conditions at the injection site. after using gynoflora for a short time, you may feel a slight burning sensation or heat.
When using the preparation, local allergic reactions are possible, including rash, hyperemia, pain, edema, itching, in persons with hypersensitivity, the development of generalized allergic reactions is possible.
If Gynoflor is accidentally taken orally, no unwanted effects should be expected.
Special instructions
Gynoflor contains components that may not completely dissolve; pill residues can sometimes be found on underwear. this does not affect the effectiveness of the preparation. with significant dryness of the vagina, before the introduction, the tablet should be moistened with a small amount of plain water, which will facilitate its dissolution.
During pregnancy and breastfeeding. Gynoflor can be used during pregnancy and lactation. Like other medicines, Gynoflor is prescribed with caution in the first trimester of pregnancy. Research data does not indicate an adverse effect of estriol and Lactobacillus acidophilus on pregnancy or fetal / newborn health.
Children. The preparation should not be used in girls who have not reached puberty.
The ability to influence the reaction rate when driving vehicles or other mechanisms. Does not affect.
Interactions
Lactobacillus acidophilus is susceptible to numerous anti-infective agents (topical or systemic). concomitant treatment with such agents may lead to a decrease in the effectiveness of gynoflora.
Overdose
Not noted.
Storage conditions
In its original packaging, refrigerated (2–8 ° C). storing gynoflora at room temperature for 1-2 weeks does not reduce its effectiveness.
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