Cardonat 20 capsules — Made in Ukraine — Free Delivery

Pharmacological properties

Cardonat is a combined preparation, the action of which is due to the synergistic effects of its constituent components.

L-carnitine is a trimethylammonium (betaine) derivative of γ-amino-β-hydroxybutyric acid, refers to agents with anabolic action. It is synthesized in the liver, kidneys and central nervous system from the amino acids lysine and methionine with the participation of iron and ascorbic acid; in blood plasma it is present in free form and in the form of acetylcarnitine esters. Carnitine is the main cofactor and regulator of fatty acid metabolism in the myocardium, liver and skeletal muscle, the only carrier of long-chain fatty acids in mitochondria, where they are β-oxidized to acetyl-CoA, which is a substrate for the formation of ATP in the Krebs cycle. Promotes the release of metabolites and toxic substances from the cytoplasm, improves metabolic processes. Under conditions of normal oxygen supply, it transfers the metabolism of cells to the oxidation of fatty acids as the most energy-consuming substrate; under conditions of hypoxia, L-carnitine removes toxic metabolites of fatty acids from mitochondria, converting cell metabolism to glucose oxidation, thus providing an antihypoxic effect. Increases efficiency, accelerates growth, causes an increase in muscle mass and a decrease in adipose tissue mass due to lipolytic action, reduces the peripheral effect of thyroid hormones, and helps to normalize the basal metabolism in hyperthyroidism. Reduces the severity of symptoms of physical and mental fatigue, has a neuro-, hepato- and cardioprotective effect, exhibits an anti-ischemic effect, helping to limit the infarction zone, improves the transmission of nerve impulses in synapses and axons by increasing the synthesis of choline and acetylcholine, glutamic acid, reduces the concentration of ammonia in nervous tissue, stimulates cellular immunity. Eliminates functional disorders of the nervous system in patients with chronic intoxications, including alcoholic genesis, softens the course of withdrawal syndrome, inhibits degenerative changes in the retinal vessels. Carnitine has an antiketogenic effect, reducing the production of ketone bodies from higher fatty acids.

Lysine is an essential amino acid that takes part in all processes of assimilation and growth, promotes ossification and growth of bone tissue, stimulates cell mitosis, improves ovogenesis and spermatogenesis, and has a direct antiviral effect on herpes simplex viruses.

Coenzyme of vitamin B12 (cobamamide) has anabolic activity, activates the metabolism of carbohydrates, proteins and lipids, participates in the synthesis of labile methyl groups, the formation of choline, methionine, nucleic acids, creatine, promotes the accumulation of compounds with sulfhydryl groups in erythrocytes. As a growth factor, it stimulates bone marrow function, which is necessary for normoblastic erythropoiesis. Cobamamide helps to normalize the impaired functions of the liver and nervous system, has an antiketogenic effect, activates the blood coagulation system, and in high doses causes an increase in the activity of thromboplastin and prothrombin.

Vitamin B1 coenzyme (cocarboxylase) has a regulating effect on metabolic processes in the body. It plays an especially important role in carbohydrate and fat metabolism, primarily in the oxidative decarboxylation of keto acids (pyruvic, α-ketoglutaric), as well as in the pentose phosphate pathway of glucose breakdown. Reduces the level of lactic and pyruvic acids in the body, improves the absorption of glucose, trophism of the nervous tissue, and exhibits a cardioprotective effect.

Coenzyme vitamin B6 (pyridoxal-5-phosphate) plays an important role in the metabolism, it is necessary for the normal functioning of the central and peripheral nervous system. It is a coenzyme of a large number of enzymes acting on the non-oxidative metabolism of amino acids (decarboxylation and transamination processes). Takes part in the exchange of tryptophan, methionine, cysteine, glutamic and other amino acids. It is of great importance for the metabolism of histamine as a coenzyme of histaminase, contributes to the normalization of lipid metabolism, increases the amount of glycogen in the liver, and improves its detoxifying properties. It catabolizes neuromuscular processes, which are especially important in childhood with delayed mental and physical development, with chronic fatigue and asthenia.

Pharmacokinetics. Have not studied.

Indications

Adults and children: physical and mental stress, including in athletes, decreased ability to work, asthenic syndrome, vegetative-vascular dystonia, during the period of convalescence after undergoing somatic and infectious diseases, as well as surgical interventions, acetonemic syndromes of various origins, liver diseases (hepatitis, cirrhosis ), metabolic cardiopathy, chronic heart failure (as part of complex therapy), to improve ossification in the complex therapy of osteoporosis and bone fractures.

Children: retardation in mental and physical development (malnutrition, anorexia, growth retardation).

Adults: peripheral neuritis, neuralgia, radiculopathy, as part of complex therapy for acute and chronic disorders of cerebral circulation (cerebral strokes and chronic cerebral ischemia), as part of complex therapy for coronary artery disease (angina pectoris, myocardial infarction), hyperhomocysteinemia, as part of complex therapy for alcohol dependence syndrome, including withdrawal symptoms, hyperthyroidism.

In obstetric and gynecological practice: gestosis of pregnant women, placental insufficiency and intrauterine growth retardation.

Application

For adults and children 15 years old, cardonate is prescribed by mouth 1-2 capsules 3 times a day after meals. children 5-15 years old are prescribed 1 capsule 2 times a day. children aged 1–5 years are recommended to take the contents of 1 capsule 1 time per day. when used in children 1–5 years old, the contents of the capsule should be pre-dissolved in 50–100 ml of any fruit juice or sweet water.

No dose adjustment is necessary for the treatment of pregnant women.

For anorexia, the preparation is used 15–20 minutes before meals.

If it is difficult to swallow the capsule (children, patients in the postoperative period, persons after a stroke), dissolution is allowed before taking the contents of the capsule in juice or sweet water.

The average duration of the course of treatment is from 3 weeks to 3 months.

Contraindications

Hypersensitivity to the components of the preparation, malignant neoplasms, peptic ulcer of the stomach or duodenum in the active phase.

Side effects

The preparation is usually well tolerated, but in rare cases, as a rule, with individual hypersensitivity, allergic reactions may occur, including a variety of skin rashes, itching of the skin, urticaria, angioedema. in this case, it is necessary to stop treatment and consult a doctor.

From the digestive system: possibly bloating, pain in the epigastric region, heartburn, nausea, vomiting, stool disturbance.

From the side of the cardiovascular system: possible accelerated heartbeat, fluctuations in blood pressure.

From the side of the central nervous system: excitement very rarely occurs.

The capsule shell contains sunset yellow FCF (E110), which can cause allergic reactions.

Special instructions

The recommended dose of the preparation should not be exceeded.

Use during pregnancy and lactation. The preparation  is used in pregnant women only as directed and under the close supervision of a physician. It is not known whether the active substances of the preparation penetrate into breast milk, therefore, during breastfeeding, Cardonate can be used when the existing benefit to the mother outweighs the potential risk of side effects in the child.

Children. Used in children over the age of 1 year.

The ability to influence the reaction rate when driving or working with other mechanisms. Does not affect.

Interactions

When combined with levodopa, the severity of its therapeutic effect may decrease due to interaction with pyridoxal. the preparation can potentiate the action of antihypertensive preparations, cardiac glycosides, peripheral vasodilators, insulin and other hypoglycemic agents.

Overdose

Possible tachycardia, dyspeptic disorders, agitation, increase or decrease in blood pressure, which disappear after discontinuation of the preparation and do not require therapeutic measures.

Storage conditions

At a temperature not exceeding 25 ° c.