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Product description

Heviran Comfort is an antiviral medicine used to treat recurrent cold sores on the lips and face caused by the herpes simplex virus. The active substance of Heviran Comfort is acyclovir, which inhibits the multiplication of herpes viruses (viruses from the Herpes group) that are pathogenic for humans. Heviran Comfort can only be used in patients with a history of herpes simplex infection. The medicine is presented as white round tablets and is intended for adults.


Treatment of recurrent cold sores on the lips and face.


1 tablet contains:
  • active ingredient: 200 mg of aciclovir,
  • other ingredients: microcrystalline cellulose, povidone, sodium carboxymethyl starch (type A), magnesium stearate.


An antiviral preparation, inhibits the multiplication of Herpes viruses that are pathogenic for humans


  • Adults: administer orally at a dose of 200 mg five times a day, every 4 hours (with a night break), for 5 days.
  • Swallow the tablets with a drink of water.
  • In the case of recurrent infections, it is particularly important to start treatment in the period preceding the onset of the precursor symptoms, i.e. itching, burning, tense feeling or just after the first lesions appear.
  • Always use the medicine exactly as described in the package leaflet or as directed by your doctor or pharmacist.
  • For patients with severe renal impairment, creatinine clearance less than 10 ml / min, only a physician can decide on the dosage of aciclovir. In such patients, the doctor may reduce the dose to 1 tablet (200 mg) twice a day, approximately every 12 hours.
  • In elderly patients, the possibility of impaired renal function should be taken into account. In patients with severe renal impairment, with a creatinine clearance less than 10 ml / min, only a doctor can decide on the dosage of aciclovir, who will adjust the dose accordingly.
  • You should drink plenty of fluids during treatment.


  • Heviran Comfort should not be used:
  • in children and adolescents under 18 years of age.
  • if you are allergic to any of the ingredients of the preparation.


Store below 25 ° C, out of the sight and reach of children.
Store in the original package in order to protect from light.

Side effects

Like all medicines, this medicine can cause side effects, although not everybody gets them.
If the following rare symptoms (may affect up to 1 in 1,000 patients) occur, contact your doctor immediately:
  • breathlessness, angioedema (e.g. swelling of the face, tongue and windpipe, causing
  • breathing disorders)
  • anaphylactic reaction (often manifested by itching, hives, shortness of breath, drop
  • blood pressure, increased heart rate).
The following side effects may also occur during treatment:
Common (affecting up to 1 in 10 patients):
  • headache, dizziness
  • nausea, vomiting, diarrhea, abdominal pain
  • itching, rash (including photosensitivity)
  • fatigue, fever.
Uncommon (may affect up to 1 in 100 patients):
  • hives
  • accelerated, diffuse hair loss (can be associated with many diseases and with the use of many preparations, its relationship to the effects of aciclovir is not certain).
Very rare (may affect up to 1 in 10,000 patients)
  • agitation, tremors
  • impaired coordination of movements (ataxia)
  • speech disorders
  • confusion, hallucinations
  • psychotic symptoms
  • brain damage (encephalopathy)
  • convulsions, drowsiness, coma
  • hepatitis and jaundice
  • acute kidney failure, kidney pain.
Kidney pain may be related to kidney (kidney) failure. Renal impairment usually disappears rapidly with the patient receiving fluids and / or reducing the dose or stopping the preparation.
Heviran Comfort can cause changes in your blood picture, and therefore your doctor may order blood tests. The following may occur during treatment:
  • increased levels of creatinine and blood urea (substances that indicate what is
  • kidney function)
  • temporary increase in liver enzymes and serum bilirubin (substances that give an indication of how the liver is working).
Very rarely
  • reduction in the number of platelets which may affect clotting. If bruises occur,
  • unexplained red or purple spots on the skin, tell your doctor.
  • low white blood cell count or anemia (anemia).


  • The preparation can be used regardless of meals.
  • Tell your doctor or pharmacist about all the medicines you are taking or have recently taken, and about the medicines you plan to use, in particular about the use of:
  • probenecid - a preparation used for gout,
  • cimetidine - a preparation used mainly in gastric and duodenal ulcers,
  • mycophenolate mofetil - a preparation used after organ transplants,
  • theophylline - a preparation used to treat asthma and other respiratory conditions.

Warnings and Precautions

Talk to your doctor or pharmacist before using Heviran Comfort. The preparation should not be used without consulting a doctor first:

  • in patients with impaired renal function,
  • in patients who are taking other preparations that can damage the kidneys,
  • in elderly patients (65 years of age or older)
  • in pregnant women or during breastfeeding,
  • in immunocompromised people (e.g. after a bone marrow transplant, HIV-infected),
  • in patients with particularly severe recurrent cold sores,
  • in case of noticing frequent (over 6 per year) and longer (after 5 days of therapy no positive effects of treatment) than before recurrences of herpes, with more severe clinical symptoms (e.g. when new foci of infection appear after 3-4 days of therapy) ).

You should drink plenty of fluids while taking this medicine to avoid damaging your kidneys.

Immunocompromised people should consult their doctor for treatment of any infection.

Pregnancy, breastfeeding and fertility

  • If you are pregnant or breastfeeding, think you may be pregnant or are planning to have a baby, ask your doctor for advice before taking this medicine.
  • Avoid using the preparation during pregnancy. The preparation may be used during pregnancy only when, in the opinion of the doctor, the expected benefit to the mother outweighs the risk to the fetus. Acyclovir is excreted in human milk. Due to the risk of side effects in a nursing baby, a decision should be made after consulting a physician whether or not to take the preparation or to discontinue breastfeeding while taking the preparation.

Driving vehicles and operating machinery

  • There are no data on the effect of the preparation on the ability to drive and use machines. However, the possibility of aciclovir side effects, such as dizziness, disorientation, convulsions, should be taken into account.
  • Do not drive or use machines unless you are sure you are feeling well.

Heviran Comfort contains sodium

  • This medicine contains less than 1 mmol sodium (23 mg) per tablet, that is to say essentially 'sodium-free'.


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