Jox-Teva oral spray 30ml — Made in Czech Republic — Free Delivery
(Jox-Teva)
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Description Jox-Teva oral spray 30ml — Made in Czech Republic — Free Delivery
Pharmacological properties
Pharmacodynamics. Iodized povidone, a disinfectant belonging to the group of substances containing iodine, releases organic iodine upon contact with the skin or mucous membrane, has a wide spectrum of antimicrobial action due to a direct effect on the proteins of microorganisms. Iodized povidone has a partially bactericidal effect on gram-positive and gram-negative cocci and bacilli, on some anaerobic bacteria, yeast or saccharomycetes, simple viruses.
The preparation also contains allantoin, which has an anti-inflammatory effect, due to which, together with iodinated povidone, the therapeutic effect of the preparation is carried out.
Pharmacokinetics. With local application of iodized povidone to intact skin, the absorption of iodine is minimal. When used in the oral cavity, a more pronounced systemic absorption of iodine is noted, as a result of which interference with thyroid function may occur. Iodine in the body turns into iodides, which accumulate mainly in the thyroid gland and are excreted mainly by the kidneys, as well as in small amounts with feces, saliva, and sweat. Iodides pass through the placental barrier and enter breast milk.
Indications
Disinfection of the oral cavity and pharynx for inflammatory and infectious diseases: tonsillitis, pharyngitis, tonsillopharyngitis, tonsillitis, glossitis and stomatitis; as part of a complex treatment with antibiotics for streptococcal sore throat; the first symptoms of ARVI.
Application
Jocks mouthwash. applied topically to the mucous membrane of the oral cavity and pharynx.
Adults and children over 6 years old. The diluted solution is used to rinse or rinse the mouth and throat. Solution should not be swallowed. Rinse or rinse the mouth and throat with 10-15 ml of diluted solution for about 30 seconds. Apply 2-4 times a day, no more than 6 times a day, with an interval between two uses of at least 4 hours.
For dilution, drinking water with a temperature of 18 ° C is used in a ratio of 1: 20–1: 40 (namely: 2.5–5 ml when using a measuring cap or ½ – 1 teaspoon per 100 ml of water). Clarification of the solution means a decrease in its antimicrobial activity.
Elderly patients and people with hepatic insufficiency are shown the same doses as adults.
Jox spray. The spray is applied topically to the mucous membrane of the oral cavity and pharynx.
The preparation is sprayed in a metered dose from a bottle with a mechanical nebulizer and an applicator for the oral cavity.
If the oral applicator is in a plastic bag, cut it open with scissors or another convenient tool and remove the applicator.
Before use, the oral applicator should be rinsed with warm water and checked for damage. A damaged applicator must not be used.
Remove the protective cap from the mechanical spray gun. Place the applicator on the bottle.
Press 2-3 times until the solution enters the sprayer and after pressing it starts to spray.
Insert the applicator tube into the oral cavity, hold your breath and press 2 times, each time directing the preparation stream to the corresponding area of the throat cavity on the right and left. When using, the bottle must be held vertically.
Do not inhale or swallow the spray solution!
Used in adults and children over the age of 8 years, as a rule, 2-4 times a day, if necessary, every 4 hours.
The spray can be applied no more than 6 times a day.
Elderly persons and patients with hepatic impairment should adjust the dose (see SPECIAL INSTRUCTIONS).
The duration of treatment depends on the nature and course of the disease and is determined by the doctor individually.
Contraindications
Hypersensitivity to the components of the preparation; Dühring's dermatitis herpetiformis; hyperthyroidism, adenoma, or thyroid dysfunction; decompensated heart failure; renal failure; 2 weeks before and after examination or therapy with radioactive iodine.
Side effects
The preparation is usually well tolerated.
The incidence of adverse events was assessed according to the following principle: very often (≥1 / 10), often (≥1 / 100, 1/10), infrequently (≥1 / 1000, 1/100), rarely (≥1 / 10,000, 1/1000), very rarely (1/10 000), including individual messages.
From the immune system: very rarely - anaphylactic shock.
From the digestive system: infrequently - dry mouth.
On the part of the skin and subcutaneous tissue: rarely - hypersensitivity reactions, including urticaria; very rarely - angioedema. Itching, hyperemia are also possible.
General disorders and changes at the injection site: infrequently - burning sensation at the site of application (especially in children), dry mouth.
Damage, poisoning and complications during the procedure: iodism (metallic taste in the mouth, increased salivation, edema of the eyes, larynx, lungs, skin rashes, gastrointestinal disorders, systemic manifestations in the form of metabolic acidosis, hypernatremia, renal dysfunction, diarrhea) after long-term use.
Special instructions
The preparation is not intended for oral administration: the preparation should not be swallowed. if within 3 days the patient's condition does not improve or an undesirable effect is observed, unusual sensations, a doctor's consultation is necessary.
It is inappropriate to simultaneously use the preparation with other antiseptic preparations intended for use in the mouth and throat.
With laryngitis, the preparation can be used only in exceptional cases.
The preparation contains 18.6% ethanol.
The preparation should be used with caution in patients with hepatic impairment. In such patients, the level of transaminases may increase, so it is necessary to monitor their levels in blood plasma.
The use of iodinated povidone may interfere with thyroid scintigraphy. Do not use iodized povidone for 1–2 weeks prior to thyroid scintigraphy.
Since it is impossible to exclude the development of hyperthyroidism, prolonged (more than 14 days) use of iodinated povidone or its use in large quantities in patients (especially the elderly) with latent thyroid dysfunction is permissible only after a careful balance of the expected benefit and possible risk. Such patients should be monitored for early signs of hyperthyroidism and proper assessment of thyroid function, even after discontinuation of the preparation (for up to 3 months).
Do not inhale or swallow the spray solution. Avoid contact with eyes. If the preparation gets into the eyes, rinse them with water.
The preparation can stain the oral mucosa, teeth, skin and clothing. Stains on mucous membranes, teeth and skin can be removed with alcohol. Stains on clothing can be removed by washing and rinsing with diluted ammonia (ammonia), sodium thiosulfate, or soap and water.
If possible, dentures and similar structures should be removed from the mouth prior to use of the preparation.
Do not heat the preparation before use, since the decomposition of active substances is enhanced by light and at temperatures above 40 ° C.
Use during pregnancy and lactation. There is no experience of topical application of iodized povidone in pregnant women. Neonates whose mothers received topical iodine (after vaginal administration before childbirth or application to the skin during pregnancy) had congenital hypothyroidism or goiter. Therefore, iodized povidone should not be used during pregnancy.
Iodine can pass into breast milk. The revealed concentrations of iodine in the blood and urine of children who were breastfed were many times higher than the concentrations observed in their mothers who used iodized povidone. High plasma iodine concentrations can lead to the development of congenital hypothyroidism in children who are breastfeeding, so iodized povidone should not be used during breastfeeding.
Children. Jox mouthwash is used in children over the age of 6; Yoks spray - in children aged 8 years and older. For children aged 8 to 12 years, the preparation should be used under medical supervision. Children should use the preparation with caution, given the possibility of laryngospasm.
The ability to influence the reaction rate when driving or working with other mechanisms. The use of the preparation does not affect the ability to drive vehicles or work with other mechanisms.
Interactions
It is not recommended to combine the preparation with other antiseptic agents for the oral cavity and pharynx, primarily with hydrogen peroxide.
Due to its oxidizing properties, iodinated povidone can interfere with the results of some diagnostic tests, such as detecting occult blood in feces or urine, or glucose in urine. The use of the preparation leads to false positive hemotest results. May interfere with some diagnostic tests (eg, thyroid scintigraphy, protein-bound iodine, radioactive iodine) or may compete with iodine used for thyroid therapy.
The use of iodinated povidone should be avoided in patients using lithium preparations, since their simultaneous use can cause a synergistic hypothyroid effect.
Iodized povidone should not be used simultaneously with preparations containing chlorhexidine, silver sulfadiazine due to possible partial inactivation. Iodized povidone interacts with strong alkalis, sodium thiosulfate, sodium metabisulfite and thiomersal, therefore, the preparation cannot be used simultaneously with these substances.
All interactions are manifested visually by discoloration of the solution, which indicates a decrease in the effectiveness of the preparation.
Do not use the preparation at the same time as disinfectants containing mercury; ointments containing enzymes or benzoin tincture; the preparation is incompatible with oxidants, alkali salts and acidic substances.
Overdose
With the correct local application of the preparation in the oral cavity or pharynx, there were no cases of overdose. however, in the case of ingestion of iodine solution, acute poisoning developed. patients initially felt a metallic taste in the mouth, vomiting, stomach pain and diarrhea began. within 1-3 days, anuria, edema of the glottis followed by asphyxia, aspiration pneumonia or pulmonary edema were observed. in some cases, vascular collapse was noted.
Treatment is symptomatic and initially includes standard measures to prevent further absorption in the gastrointestinal tract. The patient needs to drink milk and brewed starch. (To brew the starch, take 2 g of starch in a porcelain cup and mix well with 8 ml of cool clean water. Add 90 ml of boiling purified water. Stirring constantly, heat the mixture to a boil (0.5–1 min) and keep until it thickens and will not get lighter.Cool to room temperature (25 ° C) and take). If the esophagus is intact, gastric lavage can be performed. In addition, it is necessary to take activated carbon and 1–5% sodium thiosulfate solution, which ensures the reduction of iodine to iodide. There is no specific antidote.
Storage conditions
Rinse aid - in its original packaging at a temperature not exceeding 25 ° С in a place protected from light; spray - in its original packaging to protect it from moisture.
Tags: Jox
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