Lorinden A oinment 15g (Salicylic acid) — Made in Poland — Free Delivery
Pharmacodynamics. The properties of lorinden ointment are due to the combined action of flumethasone pivalate and salicylic acid.
Flumethasone pivalate is a synthetic corticosteroids with moderate anti-inflammatory properties. In the case of application in the form of an ointment, a local effect of medium intensity. It has a lipophilic effect, easily penetrates into the stratum corneum of the skin and exhibits long-term anti-inflammatory, antipruritic and anti-allergic effects. When applied externally, flumethasone pivalate inhibits the formation of prostaglandins and leukotrienes in the skin, inhibition of phospholipase A2 and the release of arachidonic acid from phospholipids of cell membranes. Suppresses phagocytosis, the release of interleukins and other cytokines that cause inflammation. Increases proliferative processes. Due to the local vasoconstrictor action, it reduces the severity of the exudative reaction. Reduces protein synthesis and collagen deposition.
Salicylic acid in the preparation has a weak keratolytic effect.
Pharmacokinetics. Flumethasone pivalate penetrates well into the stratum corneum, where it accumulates. It is not metabolized in the skin. When used externally in small quantities, penetrate into the system. After penetration through the skin, the preparation is metabolized mainly in the liver. The absorption of flumethasone pivalate is increased when applied to areas with delicate skin - in the area of folds or the face, on skin with damaged epidermis or inflammatory skin changes. The use of an occlusive dressing, which increases the temperature and the surrounding skin, also increases the absorption of flumethasone pivalate. In addition, absorption is increased with frequent use of the preparation or over large areas of the skin. Absorption through the skin in young people is more intense than in older people.
External use of salicylic acid facilitates the penetration of flumethasone pivalate through the keratinized epidermis.
Inflammation of the skin (without exudation), uncomplicated by a secondary bacterial infection, including of an allergic nature, accompanied by persistent itching and hyperkeratosis: seborrheic dermatitis, atopic dermatitis, urticaria nodosa (papular urticaria), allergic contact dermatitis, erythema multiforme, erythema erythematosus, tuberculosis lichen planus.
Designed for topical use. the ointment is applied in a thin layer on the affected skin area at first 2-3 times a day, and after the weakening of acute symptoms - 1-2 times a day. it is allowed to apply the preparation under an occlusive dressing. with the onset of clinical recovery, treatment is continued for another 3-4 days. continuous therapy should not be carried out for more than 2 weeks. should not be applied to the skin for more than 1 week. it is recommended to use no more than 1 tube of cream during the week.
With significant lichenization or excessive hyperkeratosis in the area of skin changes, the use of an occlusive dressing is allowed, which should be changed every 24–48 hours.
Hypersensitivity to GCS, salicylic acid or other components of the preparation. viral (for example, herpetic skin lesions) and fungal skin diseases, tuberculosis of the skin, skin neoplasms, acne and rosacea, perioral and diaper dermatitis, anal itching, inflammation or ulcers of varicose veins.
Do not use on large areas of the skin, especially if the integrity of the skin is compromised, for example, with burns.
On the part of the skin and subcutaneous tissue: rash, peeling of the skin, acne, post-steroid purpura, inhibition of epidermal growth, atrophy of the subcutaneous tissue, dry skin, burning sensation, irritation, itching, excessive body hair or alopecia, discoloration or hyperpigmentation of the skin, atrophy and violations of the integrity of the skin, telangiectasia, contact and perioral dermatitis, inflammation of the hair follicles, secondary infections. in some cases, may appear: urticaria, maculopapular rash or exacerbation of existing changes.
From the side of the organ of vision: when applied externally, cataracts or glaucoma can sometimes develop on the skin of the eyelids.
From the side of the cardiovascular system: hypertension.
From the endocrine system: glucosuria, hyperglycemia, dysfunction of the hypothalamic-pituitary-adrenal system, Cushing's syndrome, inhibition of growth and development in children.
Others: the use of an ointment under an occlusive dressing, given the increased absorption, can lead to a systemic effect, which manifests itself in the form of edema, hypertension, hypersensitivity to infections.
In persons with individual intolerance to the components of the preparation, hypersensitivity reactions are possible.
Do not use the preparation continuously for more than 2 weeks. with prolonged therapy on large areas of the skin, the incidence of side effects increases.
The use of the preparation should be discontinued immediately if its use leads to painful sensations or allergic reactions (itching, burning or redness of the skin). During the external use of flumethasone pivalate, the release of ACTH by the pituitary gland may decrease due to inhibition of the pituitary-adrenal connection, the level of cortisol in the blood may increase and iatrogenic Cushing's syndrome may appear, which disappears after stopping treatment. During therapy, periodic monitoring of adrenal function is carried out by determining the level of cortisol in the blood and urine after stimulation of the adrenal glands with ACTH. In the event of an infectious process at the site of application of the ointment, antibacterial or antifungal therapy should be prescribed. If the infectious process does not regress, it is necessary to stop using the ointment until the infection is eliminated.
Avoid applying the preparation to the eyelids or skin around the eyes in patients with closed-angle and open-angle glaucoma, as well as with cataracts, given the possibility of intensifying the symptoms of the disease. Avoid contact of the preparation with the eyes and mucous membranes.
On the skin of the face, groin and axillary region, apply only if there is a special need, since there may be an increase in absorption and a high risk of side effects (telangiectasia, perioral dermatitis), even after short-term use.
The use of an ointment under an occlusive dressing should be limited to exceptional cases due to the possibility of atrophy and epidermal defects, superinfection. The preparation should be used with caution in the presence of atrophy of the subcutaneous tissue, mainly in the elderly.
During the treatment of chronic conditions, such as psoriasis or chronic eczema, the preparation should not be abruptly discontinued.
It is necessary to prescribe with caution to patients with psoriasis, since local use of GCS in this case can lead to relapses of the disease due to the development of tolerance, the risk of spreading pustular psoriasis and systemic toxicity due to skin dysfunction.
The preparation contains propylene glycol and lanolin, which can cause skin irritation and local skin reactions (eg contact dermatitis).
Use during pregnancy and lactation. In studies conducted on animals, it was confirmed that GCS have a teratogenic effect even when administered orally in low doses. Teratogenic action is also confirmed with the external use of powerful GCS. There have been no controlled studies of the reliability of teratogenic action with the external use of flumethasone pivalate during pregnancy.
Lorinden A ointment can be used in women during pregnancy only for a short time, on small areas of the skin and only if, in the opinion of the doctor, the benefit outweighs the possible risk. The preparation is not used in the first trimester of pregnancy.
The degree of excretion of flumethasone pivalate into breast milk when used externally is unknown. When using GCS inside a significant amount of the hormone, which could have an effect on the body of a newborn, was not detected in breast milk. However, it is recommended to use Lorinden A ointment with caution, under the supervision of a doctor, in women during breastfeeding. In some cases, you can use the preparation for a short time on small areas of the skin. Do not apply Lorinden A ointment on the skin of the mammary glands.
Children. The preparation is not prescribed for children under 12 years of age. In children over the age of 12, the ointment is used in some cases and on small areas of the skin. The preparation should not be applied to the skin of the face.
The ability to influence the reaction rate when driving or working with other mechanisms. The preparation does not limit mental and motor ability, as well as the ability to drive vehicles or other mechanisms.
With external use of GCS, interactions with other drugs have not been identified.
During therapy, it is not recommended to vaccinate against smallpox, as well as other types of immunization, especially with prolonged use on large areas of the skin, given the possibility of an insufficient immune response.
Only with prolonged use of the ointment on large areas of the skin in response to the absorption of a significant amount of salicylic acid, there is an increase in the action of methotrexate and oral hypoglycemic drugs (sulfonylurea derivatives). Lorinden A can enhance the effect of immunosuppressive drugs and suppress the effect of immunostimulating drugs.
With prolonged use of the drug on large areas of the skin, overdose symptoms may develop, which are manifested by increased side effects (edema, burning sensation, irritation, itching, ag, hyperglycemia, decreased resistance to infections, dysfunction of the hypothalamic-pituitary-adrenal system, suppression of growth and development in children), and in severe cases - the development of Cushing's syndrome. it is necessary to gradually stop the use of the drug in a timely manner or switch to the use of GCS of weak action. rarely, symptoms of salicylate poisoning may appear: headache, dizziness, ringing in the ears, extremely rarely - impaired core indicators, decreased visual acuity. symptomatic therapy.
At a temperature not higher than 25 ° C.
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