Aflofarm Brand: Aflofarm

Ex Tax: $17.99

Product description

The preparation Melabiorim 5 mg tablets. The active substance is the hormone melatonin. This hormone occurs naturally in the human body, it is produced by the pineal gland, located in the central nervous system. Melatonin is involved in the regulation of the biological circadian rhythm. It stabilizes sleep and wakefulness throughout the day. Incidentally, Melabiorm is indicated in sleep disorders when there is a change in time zones or in connection with shift work, and facilitates the regulation of the circadian rhythm of sleep and wakefulness in blind patients.


An auxiliary agent indicated in sleep disorders caused by changing time zones or in connection with shift work, and facilitating the regulation of the circadian rhythm of sleep and wakefulness in blind patients.


Each tablet contains 5 mg melatonin, excipients: microcrystalline cellulose, magnesium stearate, colloidal silica.


Melatonin plays an important role in regulating the biological circadian rhythm. It regulates the hours of sleep and wakefulness during the day.


Adults: For time zone related sleep disorders: 2 mg to 3 mg melatonin once daily after dark, starting on the first day of travel. Continue treatment for 2 to 3 consecutive days after travel. In disorders of the circadian rhythm of sleep and wakefulness related to, for example, shift work: 1 mg to 5 mg daily an hour before bedtime. In disorders of the circadian rhythm of sleep and wakefulness in blind people, the dose should be taken from 0.5 mg to 5 mg once a day, around 21: 00-22: 00. This dosage also applies to long-term use of the preparation. The long-term effect of the preparation in the treatment of disturbances in the circadian rhythm of sleep and wakefulness sometimes only becomes apparent after 2 weeks of taking the preparation.


Hypersensitivity to the active substance or to any of the excipients. Melatonin should not be used in children and adolescents, during pregnancy and breastfeeding, and after drinking alcohol.


Store below 25 degrees Celsius in the original package in order to protect from light.

Side effects

Uncommon (more than 1 in 1000 but less than 1 in 100 patients) the following symptoms: irritability, nervousness, restlessness, insomnia, abnormal dreams, nightmares, anxiety, migraine, headache, lethargy (tiredness, lack of energy), psychomotor agitation, dizziness, somnolence, hypertension, abdominal pain, upper abdominal pain, dyspepsia, mouth ulceration, dry mouth, nausea, increased blood bilirubin, dermatitis, night sweats, pruritus, rash, generalized itching, dry skin, pain in extremity, glycosuria, proteinuria, menopausal symptoms, weakness, chest pain, drop in body temperature, liver function test abnormal, weight gain. Rare (more than 1 in 10,000, but less than 1 in 1,000 patients): increased number of seizures in children with CNS lesions and epilepsy, hives, eczema, erythema, dermatitis, psoriasis, generalized rash, rash with itching, changes in the nail plate, enlargement of the breast in men (gynaecomastia), herpes zoster, decreased white blood cells, decreased platelet count, increased blood triglycerides, decreased blood calcium, decreased sodium in blood, mood changes, aggression , agitation, crying, symptoms of tension, confusion, waking up early in the morning, increased libido (increased sex drive), depressed mood, depression, fainting, memory impairment, concentration disturbance, daydreaming, restless leg syndrome, poor sleep quality, tingling or numbness , reduced visual acuity, blurred vision, increased tearing, dizziness when changing position, disturbance in balance, angina pectoris, palpitations, tachycardia, flushing to the head ("hot flush"), gastroesophageal reflux disease, gastrointestinal disorders, blisters in the mouth, tongue ulceration, stomach upset, vomiting, abnormal peristalsis sounds intestines, gas, excessive salivation, halitosis, abdominal discomfort, stomach upset, gastritis, arthritis, muscle spasms, neck pain, night cramps, polyuria, haematuria, bedwetting, prolonged painful erection (priapism), inflammation of the gland prostate, fatigue, pain, thirst, increased liver enzymes, abnormal blood electrolytes, abnormal laboratory test results. Not known (cannot be estimated from the available data): hypersensitivity reaction; swelling of the face, lips or tongue which may make it difficult to swallow and swallow; if such symptoms occur, contact your doctor immediately; galactorrhea.


Fluvoxamine (an antidepressant) and other preparatiosnthat are metabolized by the liver, such as citalopram (an antidepressant), omeprazole, lansoprazole (preparations for peptic ulcer and gastro-esophageal reflux disease) increase the blood levels of concomitantly administered melatonin. Other medicines that may affect the effect of melatonin: 5- or 8-methoxypsoralen (used to treat psoriasis), cimetidine (used to treat peptic ulcer disease), estrogens (contraceptives and hormone replacement therapy), quinolones (antibacterials), thioridazine (used psychiatric disorders), imipramine (used to treat depression), carbamazepine (used to treat epilepsy), rifampicin (an antibacterial agent), sleeping pills and tranquilizers, e.g. benzodiazepines, zaleplon, zolpidem and zopiclone, adrenergic agonists / antagonists (such as preparations such as certain types of preparations used to control blood pressure by constricting blood vessels, nasal decongestants, preparations to lower blood pressure), opioid agonists or antagonists (such as preparations used to treat preparation addiction), prostaglandin inhibitors (such as non-steroidal anti-inflammatory preparations) , antidepressants, tryptophan.


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