Milistan multisymptomic 12 tablets — Made in India — Free Delivery

Pharmacological properties

Paracetamol has analgesic, antipyretic and mild anti-inflammatory effects. the mechanism of action is due to the inhibition of the synthesis of prostaglandins and the predominant effect on the center of thermoregulation in the hypothalamus.

Cetirizine hydrochloride is a selective antagonist of peripheral H1-histamine receptors, a metabolite of hydroxyzine. Possesses antiallergic properties due to inhibition of the late phase of cell migration, which are involved in the inflammatory response (mainly eosinophilic granulocytes); also reduces the expression of adhesion molecules such as ICAM-1 and VCAM-1, which are markers of allergic inflammation. It inhibits the action of other mediators and inducers of histamine secretion, such as platelet activation factor and substance R. Virtually does not cause anticholinergic and antiserotonin effects. In therapeutic doses, it does not have a sedative effect.

Dextromethorphan hydrobromide is an antitussive agent that is effective for unproductive coughs that result from bronchial irritation. The mechanism of action is due to the effect on the cough center in the medulla oblongata.

Chlorpheniramine (chlorphenamine) maleate - antiallergic agent, blocker of H1 receptors. It has a moderately pronounced sedative effect.

After oral administration, the preparation is rapidly and almost completely absorbed from the digestive tract. Simultaneous food intake practically does not affect the absorption of the components of the preparation. Paracetamol is well distributed in tissues (excluding adipose tissue) and CSF. The binding of paracetamol to blood plasma proteins is 10% and slightly increases with an overdose. Cetirizine is also able to bind to blood plasma proteins. It has a low volume of distribution (0.5 l / kg), does not penetrate cells. Paracetamol is metabolized mainly in the liver by conjugation with glucuronide, sulfate and oxidation with the participation of mixed liver oxidases and cytochrome P450. Cetirizine is practically not metabolized in the liver. Dextromethorphan hydrobromide is rapidly and almost completely metabolized in the liver to the active metabolite of dextrorphan.

The half-life of paracetamol is 1-3 hours. In patients with liver cirrhosis, the half-life is increased. The renal clearance of paracetamol is 5%. It is excreted in the urine, mainly in the form of glucuronide and sulfate conjugates, less than 5% - in the form of unchanged paracetamol. The preparation is excreted in breast milk. After a single oral dose of cetirizine hydrochloride, its half-life is approximately 10 hours. The half-life of dextromethorphan hydrobromide is approximately 4 hours, the preparation is excreted unchanged by the kidneys, as well as in the form of demethylated metabolites (including dextrorphan). The active ingredients of the preparation penetrate the placenta and are excreted in breast milk.

Indications

Symptomatic treatment of influenza and other acute respiratory infections, which are accompanied by fever, myalgia and arthralgia, headache, dry cough, nasal congestion, rhinorrhea, lacrimation; hay fever, allergic rhinitis and other allergic diseases of the upper respiratory tract; pain syndrome of low and medium intensity of various origins (headache, toothache, migraine, neuralgia, myalgia, algomenorrhea, pain in trauma, burns), fever in infectious and inflammatory diseases.

Application

For adults and children over 12 years of age, the preparation is administered orally 1 caplet 1 time per day. The maximum duration of treatment is 5-7 days.

The maximum period of use for children without consulting a doctor is 3 days.

Contraindications

Hypersensitivity to the components of the preparation, chronic alcoholism, severe liver and / or kidney dysfunction, deficiency of the enzyme glucose-6-phosphate dehydrogenase, blood diseases, pregnancy and lactation. the suspension is not prescribed for children under the age of 1 year, and caplets - up to 12 years.

Side effects

They rarely occur. due to prolonged use of the preparation in high doses, drowsiness, sleep disturbances, increased excitability, pain in the epigastric region, nausea, hepatotoxic effect (caused by paracetamol) may occur; pruritus, rash, angioedema, anemia, thrombocytopenia; dry mouth, difficulty urinating, impaired accommodation, increased intraocular pressure (due to the anticholinergic effect of chlorpheniramine).

Special instructions

The use of the preparation during pregnancy is possible only in cases where the expected therapeutic effect for the expectant mother outweighs the potential risk to the fetus. it is advisable to refrain from using the preparation during breastfeeding.

Use with caution in patients with impaired liver, digestive tract and kidney function, with benign hyperbilirubinemia, angle-closure glaucoma, prostatic hypertrophy, epilepsy, urinary retention, severe cardiovascular diseases, diabetes mellitus, asthma, productive cough, as well as in elderly patients age. With prolonged treatment with the preparation, it is necessary to control the composition of the peripheral blood and the functional state of the liver (once every 10 days).

During the use of the preparation, you should avoid driving vehicles, working with mechanisms, and other potentially hazardous activities. You must not drink alcohol!

Interactions

When used simultaneously with barbiturates, anticonvulsants, rifampicin and alcohol, the risk of hepatotoxic action is significantly increased.

With the simultaneous use of Milistan Multisymptomatic with metoclopramide, an increase in the absorption of paracetamol is possible.

With simultaneous administration with coumarin derivatives, slight hypoprothrombinemia may develop.

Caffeine can potentiate the pain relieving effect of paracetamol.

Overdose

Sleep disturbance, skin rash, itching, urinary retention, fatigue, tremor, tachycardia are possible. carry out symptomatic therapy, hemodialysis is not effective.

Storage conditions

In a dark place at a temperature of 15-25 ° C.