Movex Active 60 tablets — Made in Switzerland — Free Delivery

Movex active has anti-inflammatory, analgesic, chondroprotective and regenerative effects. slows down the processes of damage to cartilage tissue and resorption of bone tissue, restores cartilaginous tissue, accelerates the formation of callus in trauma, and helps to restore the function of joints.

Pharmacodynamics. Glucosamine is a substrate for the construction of articular cartilage and stimulates the regeneration of cartilage tissue. Any adverse effect (disease, age-related metabolic disorders, injuries) reduces its synthesis and concentration in the connective tissue, which leads to disruption of the structure, function of the joints and the appearance of pain. Glycosaminoglycans and proteoglycans are part of the complex matrix that makes up cartilage.

Glucosamine is a part of endogenous glycosaminoglycans in cartilage tissue, stimulates the production of proteoglycans and increases the absorption of sulfate by the articular cartilage.

Thus, glucosamine compensates for endogenous glucosamine deficiency. Takes part in the biosynthesis of proteoglycans and hyaluronic acid, which counteracts the progression of degenerative processes in the joints, spine and surrounding soft tissues; stimulates the formation of chondroitinsulfuric acid, normalizes the accumulation of calcium in bone tissue, helps to restore the functions of the joints and the disappearance of pain.

Chondroitin sulfate is a high molecular weight mucopolysaccharide that affects phosphorus-calcium metabolism in cartilage tissue. It slows down bone resorption, cartilage degeneration processes and reduces calcium loss. It has a chondroprotective effect under normal conditions and under conditions of destruction of cartilaginous tissue, stimulates the regeneration of cartilage tissue, has an anti-inflammatory, analgesic effect. It prevents the compression of connective tissue, “lubricates” the articular surfaces and normalizes the production of joint fluid.

Potassium diclofenac is an NSAID with analgesic, anti-inflammatory and antipyretic action, has a rapid onset of action, which is especially important for the treatment of acute pain in inflammation. The mechanism of action is based on the inhibition of the synthesis of prostaglandins, which play a major role in the development of inflammation, pain and fever. The anti-inflammatory, analgesic and antipyretic properties of NSAIDs are associated with their ability to inhibit prostaglandin synthesis by blocking the synthesis of the COX enzyme. Reduces pain at rest and during movement, reduces the manifestations of morning stiffness in the joints, swelling of soft tissues, improves the functional state of the musculoskeletal system. Diclofenac potassium predominantly suppresses the phase of exudation, to a lesser extent - proliferation, reducing collagen synthesis and the associated tissue hardening.

Pharmacokinetics. Glucosamine sulfate. Oral bioavailability of glucosamine is 25–26%. After distribution in tissues, the highest concentrations are determined in the liver, kidneys and cartilage tissue. About 90% of the glucosamine that enters the body after oral administration is absorbed in the small intestine in the form of the glucosamine salt and enters the liver through the portal bloodstream. A significant portion of the glucosamine that is absorbed is metabolized in the liver. Decomposes to urea, water and carbon dioxide. About 30% of the dose taken persists for a long time in the connective tissue. It is excreted mainly by the kidneys and in a very small amount - with feces.

Chondroitin sulfate. After a single dose of chondroitin Cmax in the blood plasma is achieved after 3-4 hours, in the synovial fluid - after 4-5 hours. The concentration in the synovial fluid exceeds that in the blood plasma. The bioavailability of chondroitin sulfate is 13-15%. Excreted by the kidneys for 24 hours.

Potassium diclofenac is not cumulated. Cmax in blood plasma is achieved 2 hours after administration. Plasma protein binding - 99.7%. Penetrates into synovial fluid. The systemic clearance of the active substance is 263 ml / min. T1 / 2 from blood plasma - 1–2 hours. 60% is excreted by the kidneys in the form of metabolites, less than 1% - by the kidneys in unchanged form, the remainder - in the form of metabolites with bile.

Treatment of diseases of the musculoskeletal system, which are accompanied by signs of inflammation, pain, degenerative-dystrophic changes in the cartilage tissue of the joints and spine, decreased joint mobility; osteoarthritis, periarthritis (including knee, hip joints, intervertebral osteochondrosis, spondyloarthritis), rheumatoid arthritis, fractures and injuries (to accelerate the formation of callus), post-traumatic inflammation of soft tissues and musculoskeletal system (due to stretching, shock).