Nimid granules 100 mg/2 g, 2g x 30 sachets — Made in India — Free Delivery

Pharmacodynamic parameters. Nimesulide - the active ingredient of nimide - is npvp, a derivative of nitrobenzene. Nimesulide inhibits the CO-mediated process of conversion of arachidonic acid to the precursor of prostaglandins, prostacyclin and thromboxane a2. Nimesulide has both analgesic and antipyretic and anti-inflammatory properties mediated by the action of Tsog-2, but has little effect on platelet function or loss of gastric cytoprotection associated with Tsog-1 activity.

Pharmacokinetic parameters. Nimesulide has a rapid onset of action, with a high absorption rate after oral administration (Cmax in blood plasma is reached after 2-3 hours). All oral formulations exhibit high and equivalent bioavailability. Nimesulide is tightly bound to blood plasma proteins (up to 97.5%) and has a moderately small volume of distribution. However, it is rapidly distributed in the synovial fluid.

Nimesulide is metabolized in oxidation reactions through the cytochrome P450 system of the liver (mainly CYP 2C9), mainly to 4-hydroxy metabolite (4-OH-NME), which has pharmacological properties similar to the parent preparation.

Elimination of nimesulide is progressive, T½ is 2–5 hours for the parent preparation and 3–9 hours for its main metabolite 4-OH-NME.

It is excreted in the form of metabolites by the kidneys (about 50% of the administered dose) and with feces (about 29%). In an unchanged state, 1–3% of the dose is excreted. Changes in pharmacokinetic parameters in elderly patients are not observed.

Sharp pain; primary dysmenorrhea.

Exclusively as a second-line preparation after a balanced analysis of all individual risks to the patient.

After eating, drink plenty of liquid. The contents of the sachet should be dissolved in 1 glass of warm water and immediately drunk.

Application period ≤15 days.

Adults and children aged 12 years - 2 times a day, 1 tablet / 1 sachet (the dose for elderly patients and patients with mild or moderate renal failure is not adjusted).

Eosinophilia, anemia (rare); a decrease in the number of platelets (≤150⋅109 / l) or all blood cells, purpura (very rare); rash, itching, hyperhidrosis (sometimes); dermatitis, erythema (rare); angioedema, facial edema, urticaria, Lyell's syndrome, Stevens-Johnson syndrome, erythema polymorphism (very rare); hypersensitivity (rare); anaphylactic reactions (very rare); increased heart rate 90 beats / min (rarely), hemorrhages, lability hell, hot flushes; ag (sometimes); swelling (sometimes); weakness, malaise (rare); decreased body temperature (very rare); dizziness (sometimes); cephalalgia, hypersomnia, encephalopathy / rhea syndrome (very rare); blurred vision (rare); feeling of fear, nervousness, fearful dreams (rare); dyspnea (sometimes); ba, bronchospasm (very rare); cholestasis, hepatitis, including fulminant (very rare); vomiting, nausea, diarrhea (often); constipation, flatulence, gastritis (sometimes); stomatitis, dyspepsia, abdominal pain, melena, gastrointestinal bleeding, duodenal ulcer and perforation (very rare); difficulty, urinary retention, hematuria (rare); renal failure, decreased urine output, interstitial nephritis (very rare); increased potassium levels in the blood (rare); increased activity of liver enzymes (often).