Omez DSR 30 capsules — Made in India — Free Delivery

Pharmacodynamics. A combined preparation, the action of which is due to the components that make up its composition.

Omeprazole belongs to antiulcer preparations that suppress basal and stimulated secretion of hydrochloric acid in the parietal cells of the stomach due to a specific effect on H + / K + -ATPase (proton pump). The antisecretory effect after taking omeprazole develops very quickly within an hour and lasts throughout the day. Omeprazole, due to its high lipophilicity, easily penetrates into the parietal cells of the stomach, concentrates in them and has a cytoprotective effect. The inhibitory effect increases in the first 4 days of administration. Omeprazole does not affect gastrointestinal motility. Domperidone blocks peripheral dopamine receptors, eliminates the inhibitory effect of dopamine on the motor function of the gastrointestinal tract and increases the evacuation and motor activity of the stomach. It has an antiemetic effect, relieves hiccups and eliminates nausea. Poorly penetrates the BBB, practically does not affect the dopamine receptors in the brain.

Pharmacokinetics. Omeprazole is rapidly and completely absorbed after oral administration on an empty stomach; when taken after a meal, the absorption process may take longer. Although T1 / 2 of omeprazole is short-lived (0.5-1.5 hours), the antisecretory effect persists for 24 hours or more. About 90–95% of omeprazole binds to blood plasma proteins. A limited amount of omeprazole penetrates the BBB. Most (77%) is excreted in the urine in the form of metabolites (of which hydroxyomeprazole and the corresponding carboxylic acid are identified), the rest is excreted in the feces (which suggests a significant excretion of metabolites in the bile).

In patients with chronic liver disease, the bioavailability of the preparation increases to 100%, and T½ increases to 3 hours. In patients with chronic kidney disease and elderly patients, the elimination of omeprazole decreases in proportion to the decrease in creatinine clearance, and the plasma concentration increases.

Domperidone is well absorbed after administration. Intensive metabolism takes place in the wall of the stomach and liver. Has a low bioavailability (15%). Cmax in blood plasma is reached 1 hour after application. A decrease in gastric acidity reduces the absorption of domperidone. Binds to blood plasma proteins by 91–93%. It is excreted in feces (66%) and urine (33%). T½ is about 9 hours, with severe renal failure, T½ increases.

Functional dyspepsia; delayed evacuation of stomach contents and gastroparesis; gastroesophageal reflux disease; ulcers of the stomach and duodenum; in the schemes of helicobacter pylori eradication in the presence of gastroesophageal reflux.

The capsules are taken orally whole, without breaking or chewing. the recommended dose for adults and children over the age of 12 is 1 capsule 1 time per day, 1 hour before meals. the course of treatment depends on the course of the disease and is set individually, usually 4–8 weeks.

Hypersensitivity to the components of the preparation, gastrointestinal bleeding, mechanical intestinal obstruction, perforation of the stomach or intestines, prolactinoma, pregnancy and lactation, children under 12 years of age.

Most patients tolerate the preparation well. adverse reactions reported with treatment were usually minor and reversible.

With prolonged use of omeprazole, the following side reactions may occur:

from the digestive tract: diarrhea, constipation, abdominal pain, nausea, vomiting, flatulence, dry mouth, stomatitis, gastrointestinal candidiasis, change in taste;

from the central and peripheral nervous system: headache, dizziness, paresthesia, drowsiness, insomnia; in some cases - anxiety, depression, hallucinations, confusion;

on the part of the musculoskeletal system: in some cases - arthralgia, myalgia, muscle weakness;